1. |
- Kanai, M, et al.
(författare)
-
- 2023
-
swepub:Mat__t
|
|
2. |
|
|
3. |
|
|
4. |
- Niemi, MEK, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
5. |
- Abazov, V. M., et al.
(författare)
-
Search for pair production of second generation scalar leptoquarks
- 2009
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 671:2, s. 224-232
-
Tidskriftsartikel (refereegranskat)abstract
- We report on a search for the pair production of second generation scalar leptoquarks (LQ) in p (p) over bar collisions at the center of mass energy root s- = 1.96 TeV using a data set corresponding to an integrated luminosity of 1.0 fb(-1) collected with the D empty set experiment at the Fermilab Tevatron Collider. Topologies arising from the LQ (LQ) over bar -> mu q nu q and LQ (LQ) over bar -> mu q mu q decay modes are investigated. No excess of data over the standard model prediction is observed and upper limits on the leptoquark pair production cross section are derived at the 95% C.L. as a function of the leptoquark mass and the branching fraction beta for the decay LQ -> mu q. These are interpreted as lower limits on the leptoquark mass as a function of beta. For beta = 1 (0.5), scalar second generation leptoquarks with masses up to 316 GeV (270 GeV) are excluded.
|
|
6. |
|
|
7. |
- David, A, et al.
(författare)
-
Acid-labile subunit deficiency and growth failure: description of two novel cases
- 2010
-
Ingår i: Hormone research in paediatrics. - : S. Karger AG. - 1663-2826 .- 1663-2818. ; 73:5, s. 328-334
-
Tidskriftsartikel (refereegranskat)abstract
- <i>Background/Aims:</i> Mutations in the acid-labile subunit (ALS) gene <i>(IGFALS)</i> have been associated with circulating insulin-like growth factor I (IGF-I) deficiency and short stature. Whether severe pubertal delay is also part of the phenotype remains controversial due to the small number of cases reported. We report 2 children with a history of growth failure due to novel <i>IGFALS</i> mutations. <i>Methods:</i> The growth hormone receptor gene <i>(GHR)</i> and <i>IGFALS</i> were analyzed by direct sequencing. Ternary complex formation was studied by size exclusion chromatography. <i>Results:</i> Two boys of 13.3 and 10.6 years, with pubertal stages 2 and 1, had mild short stature (–3.2 and –2.8 SDS, respectively) and a biochemical profile suggestive of growth hormone resistance. No defects were identified in the <i>GHR</i>. Patient 1 was homozygous for the <i>IGFALS</i> missense mutation P73L. Patient 2 was a compound heterozygote for the missense mutation L134Q and a novel GGC to AG substitution at position 546–548 (546–548delGGCinsAG). The latter causes a frameshift and the appearance of a premature stop codon. Size exclusion chromatography showed no peaks corresponding to ternary and binary complexes in either patient. <i>Conclusion:</i> Screening of the <i>IGFALS</i> is important in children with short stature associated with low serum IGF-I, IGFBP-3 and ALS.
|
|
8. |
|
|
9. |
- Hunter, KE, et al.
(författare)
-
Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity
- 2022
-
Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 12:1, s. e048166-
-
Tidskriftsartikel (refereegranskat)abstract
- Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups.Methods and analysisSystematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events.Ethics and disseminationApproved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases.PROSPERO registration numberCRD42020177408.
|
|
10. |
|
|