| 1. |
- Caton, Summer A., et al.
(författare)
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Evolution of the sources of TTG and associated rocks during the Archean from in-situ 87Sr/86Sr isotope analysis of apatite by LA-MC-ICPMS
- 2022
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Ingår i: Lithos. - : Elsevier BV. - 0024-4937 .- 1872-6143. ; 428-429
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Tidskriftsartikel (refereegranskat)abstract
- Radiogenic isotopes provide an important means towards elucidating Archean crustal evolution. The global Hf and Nd isotope record of Archean crustal fragments has been instrumental to unveiling the history of ancient crustal growth and differentiation. The Rb-Sr system could provide valuable complementary constraints in this regard, as this system is particularly sensitive to magmatic fractionation processes, and the chemical and isotopic evolution of magma sources. Application of this system has so far been complicated, however, by its susceptibility to isotope re-equilibration or alteration of the Rb/Sr parent-daughter ratio. In-situ Sr isotope analysis of primary igneous minerals with very low Rb/Sr, such as apatite, provides a new means to determine the initial 87Sr/86Sr (87Sr/86Sri) values for igneous rocks directly. In this study, we apply in-situ Sr isotope analysis of apatite by LA-MC-ICPMS to tonalite-trondhjemite-granodiorite (TTG) rocks and end-member sanukitoids from Archean cratons worldwide. The 87Sr/86Sri values of sanukitoids are relatively radiogenic, supporting the model in which such rocks are formed by flux melting of a mantle strongly enriched by metasomatism, possibly by slab-derived fluids. The 87Sr/86Sri values for TTGs formed between 3.72 and 3.45 Ga are generally radiogenic, indicating aged amphibolite sources. The 87Sr/86Sri values of younger TTGs are systematically lower and were derived from mafic sources that had an average age of ≤0.2 Gyr. This evolution matches with observations from Hf isotopes for TTGs of similar age and indicates a systematic change in the nature or efficiency of TTG crust formation during the Paleoarchean. In-situ Sr isotope analysis of apatite provides a useful method to uncover the Sr record of the early continental crust, and enables constraints on local source evolution and the general two-step evolutionary process of Archean crust formation.
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| 2. |
- Dziggel, A., et al.
(författare)
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Thermal structure and evolution of an Archean large hot orogen : Insights from the Tasiusarsuaq terrane, SW Greenland
- 2019
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Ingår i: Precambrian Research. - : Elsevier BV. - 0301-9268. ; 335
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Tidskriftsartikel (refereegranskat)abstract
- The Tasiusarsuaq terrane represents an Archean continental upper plate that was assembled and thickened by a series of igneous and tectonic events between c. 2970 and 2700 Ma. A review of the available data combined with thermodynamic modelling and U-Pb titanite and zircon dating allows detailed insight into the processes of crustal growth during the Meso- and Neoarchean. Following the intrusion of the c. 2970–2950 Ma Fiskenæsset complex in an arc-type setting, the southern part of the Tasiusarsuaq terrane was intruded by an early TTG generation between c. 2920 and 2880 Ma to create the Bjørnesund block. Subsequently, from c. 2880 to 2830 Ma, TTG magmatism migrated to the Sermilik block in the central and northern part of the Tasiusarsuaq terrane, whereas monzogranite magmatism occurred in the south. We interpret this pattern of igneous activity to be a result of accretion of the Sermilik block to the Bjørnesund block and the formation of a new plate interface behind the accreted terrane. Fabrics related to this early accretionary stage are preserved in the prograde amphibolite facies (580–630 °C; 4–6 kbar) lithologies from the Bjørnesund block that have U-Pb titanite ages of c. 2820 Ma. Afterwards, ongoing southwards-directed subduction led to substantial thickening, manifested by high-pressure granulite facies metamorphism (870 °C, 9.0–9.2 kbar) and the intrusion of the c. 2805–2785 Ma Ilivertalik intrusive complex. Convergence and underthrusting by Eoarchean continental crust (Færingehavn terrane) at c. 2760 to 2720 Ma led to the extrusion of hot, ductile granulite nappes into the mid crust. At this time, large sections of the Tasiusarsuaq terrane underwent extensive amphibolite facies reworking, at conditions ranging from ~725 °C to 5.0–5.5 kbar in the central parts to 6.5–7 kbar and 700 °C in the north. These conditions lasted until the final collision of the terranes at 2720–2700 Ma. Collectively, our model describes the evolution of an Archean large hot orogen that is characterized by continuous convergence rather than intermittent subduction. In many respects, it resembles more recent large hot orogens such as the Grenville, including the accretion of terranes prior to collisional orogeny.
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| 3. |
- Gyllenberg, A, et al.
(författare)
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Variability in the CIITA gene interacts with HLA in multiple sclerosis.
- 2014
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Ingår i: Genes and immunity. - Stockholm : Springer Science and Business Media LLC. - 1476-5470 .- 1466-4879. ; 15, s. 162-167
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Tidskriftsartikel (refereegranskat)abstract
- The human leukocyte antigen (HLA) is the main genetic determinant of multiple sclerosis (MS) risk. Within the HLA, the class II HLA-DRB1*15:01 allele exerts a disease-promoting effect, whereas the class I HLA-A*02 allele is protective. The CIITA gene is crucial for expression of class II HLA molecules and has previously been found to associate with several autoimmune diseases, including MS and type 1 diabetes. We here performed association analyses with CIITA in 2000 MS cases and up to 6900 controls as well as interaction analysis with HLA. We find that the previously investigated single-nucleotide polymorphism rs4774 is associated with MS risk in cases carrying the HLA-DRB1*15 allele (P=0.01, odds ratio (OR): 1.21, 95% confidence interval (CI): 1.04-1.40) or the HLA-A*02 allele (P=0.01, OR: 1.33, 95% CI: 1.07-1.64) and that these associations are independent of the adjacent confirmed MS susceptibility gene CLEC16A. We also confirm interaction between rs4774 and HLA-DRB1*15:01 such that individuals carrying the risk allele for rs4774 and HLA-DRB1*15:01 have a higher than expected risk for MS. In conclusion, our findings support previous data that variability in the CIITA gene affects MS risk, but also that the effect is modulated by MS-associated HLA haplotypes. These findings further underscore the biological importance of HLA for MS risk.Genes and Immunity advance online publication, 16 January 2014; doi:10.1038/gene.2013.71.
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| 4. |
- Hollis, J. A., et al.
(författare)
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Detrital zircon U-Pb-Hf and O isotope character of the Cahill Formation and Nourlangie Schist, Pine Creek Orogen: Implications for the tectonic correlation and evolution of the North Australian Craton
- 2014
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Ingår i: Precambrian Research. - : Elsevier BV. - 0301-9268. ; 246, s. 35-53
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Tidskriftsartikel (refereegranskat)abstract
- Detrital zircon age and Hf isotope patterns for the Cahill Formation and Nourlangie Schist are distinctly different from other Paleoproterozoic successions in the North Australian Craton. The Cahill Formation and Nourlangie Schist comprise the bulk of the Paleoproterozoic strata in the Nimbuwah Domain, the easternmost part of the Pine Creek Orogen on the northern margin of the North Australian Craton. They comprise micaceous and quartzofeldspathic schist, carbonaceous schist, calc-silicate rock, amphibolite and quartzite, deformed and metamorphosed during emplacement of the granitic to dioritic Nimbuwah Complex at 1867-1857 Ma. The Cahill Formation hosts several world-class uranium deposits including Ranger, Jabiluka and Nabarlek. U-Pb SHRIMP and LA-SF-ICPMS detrital zircon spectra for four samples of the Cahill Formation and six samples of the Nourlangie Schist show a similar broad spectrum of ages mainly in the range 3300-1900 Ma. A ubiquitous dominant peak at 2530-2470 Ma matches the age of underlying Neoarchean basement, but is distinct in its dominantly mantle-like Hf and O zircon isotopic character, which shows closer similarity with possible source rocks from the Gawler Craton or alternatively from the Dharwar Craton. Common smaller age peaks occur at 2180 Ma, 2080 Ma and 2020 Ma. The first two have no known magmatic age correlatives in the North Australian Craton. Zircons of the 2020 Ma peak have distinctively unradiogenic Hf and elevated delta O-18, at variance with local rocks of this age but similar to detrital zircon of the same age from the Gawler Craton. In contrast to younger Proterozoic sedimentary successions within the Pine Creek Orogen, which contain ubiquitous ca. 1870 Ma detritus, the detrital spectra for the Cahill Formation and Nourlangie Schist contain almost no ca. 1870 Ma detritus. A maximum deposition age of ca. 1866 Ma indicates deposition within error of intrusion of the Nimbuwah Complex. We propose that the Cahill Formation and Nourlangie Schist were deposited at a plate margin immediately prior to convergent tectonism. This resulted in their burial, deformation and amphibolite facies metamorphism during orogenesis associated with the Nimbuwah Event. These findings have implications for understanding the Paleoproterozoic evolution of the Pine Creek Orogen within the context of northern Australia. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.
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| 5. |
- Billström, Kjell, et al.
(författare)
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Sandstone-hosted Pb-Zn deposits along the margin of the Scandinavian Caledonides and their possible relationship with nearby Pb-Zn vein mineralisation
- 2020
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Ingår i: Ore Geology Reviews. - : Elsevier BV. - 0169-1368 .- 1872-7360. ; 127
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Forskningsöversikt (refereegranskat)abstract
- Numerous sandstone-hosted Pb-Zn deposits occur along the present-day erosional front of the eastern Scandinavian Caledonides. The largest deposit is Laisvall (64.3 Mt at 4.0% Pb, 0.6% Zn and 9.0 g/t Ag) and since mineralisations generally share similar characteristics (reminding of both SEDEX and MVT-style) the term Laisvall-type has often been used. Typically, mineralised zones occur along sedimentary bedding and consist of disseminated galena and sphalerite and lesser amounts of calcite, fluorite, baryte, pyrite and sericite forming a cement that fill interstitial pores in Neoproterozoic/Eocambrian (e.g. Laisvall) to Cambrian (e.g. Vassbo) sandstones. Deposits occur both in autochtonous and allochtonous sedimentary rocks, and a broad consensus exists about their epigenetic nature, their spatial relationships to syn-sedimentary faults and that ore fluids have scavenged metals from the crystalline basement. However, the detailed ore depositional history and the timing of ore deposition have remained more controversial. New analyses aimed to complement earlier Rb-Sr data (crush-leach technique using sphalerite) fail to support a published three-point isochron age of 467 +/- 5 Ma. This is probably due to syn-ore mixing between fluids carrying isotopically variable strontium and inherited problems to analyse sphalerite grains that strictly were deposited from a single ore pulse. Tentatively, strontium in the ores originate from a mix of components derived from the basement, seawater and the local sedimentary host sequences. The lead component has highly radiogenic compositions, and data define sub-parallel linear arrays interpreted to essentially represent mixing of isotopically different types of lead released from regional basement rocks. There are obvious similarities when comparing features of deposits representing two Pb-Zn ore styles, the sandstone-hosted dissemination and the fracture-controlled mineralisation in the granite-dominated basement occurring further east of the Caledonian margin. These include low temperature brines responsible for mineral deposition, the mineralogy and the nature of Rb-Sr and Pb isotope data. We suggest that these types of mineralisation have a common origin and time of emplacement, but it is elusive to propose a well-constrained age. Nonetheless, field observations and other evidence suggest that ore formation is due to large-scale fluid flow triggered by the transition from an extensional to compressional tectonic setting at about 500 Ma. Connected to this mid-Cambrian stage was the development of syn-sedimentary faults and fractures in the basement and in overlying consolidated sandstones. The opening of such zones of weakness enabled a movement of ore-forming fluids infilling pore space in sandstones (disseminated ore) and fractures in the basement (vein ore).
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| 6. |
- Kiviniemi, T., et al.
(författare)
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A randomized prospective multicenter trial for stroke prevention by prophylactic surgical closure of the left atrial appendage in patients undergoing bioprosthetic aortic valve surgery––LAA-CLOSURE trial protocol
- 2021
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Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 237, s. 127-134
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Tidskriftsartikel (refereegranskat)abstract
- Patients undergoing surgical aortic valve replacement (SAVR) are at high risk for atrial fibrillation (AF) and stroke after surgery. There is an unmet clinical need to improve stroke prevention in this patient population. The LAA-CLOSURE trial aims to assess the efficacy and safety of prophylactic surgical closure of the left atrial appendage for stroke and cardiovascular death prevention in patients undergoing bioprosthetic SAVR. This randomized, open-label, prospective multicenter trial will enroll 1,040 patients at 13 European sites. The primary endpoint is a composite of cardiovascular mortality, stroke and systemic embolism at 5 years. Secondary endpoints include cardiovascular mortality, stroke, systemic embolism, bleed fulfilling academic research consortium (BARC) criteria, hospitalization for decompensated heart failure and health economic evaluation. Sample size is based on 30% risk reduction in time to event analysis of primary endpoint. Prespecified reports include 30-day safety analysis focusing on AF occurrence and short-term outcomes and interim analyses at 1 and 3 years for primary and secondary outcomes. Additionally, substudies will be performed on the completeness of the closure using transesophageal echocardiography/cardiac computed tomography and long-term ECG recording at one year after the operation. © 2021 The Author(s)
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| 7. |
- Landin-Olsson, M., et al.
(författare)
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Islet cell and thyrogastric antibodies in 633 consecutive 15- to 34-yr-old patients in the diabetes incidence study in Sweden
- 1992
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 41:8, s. 1022-1027
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Tidskriftsartikel (refereegranskat)abstract
- The effect of age on ICA and thyrogastric antibodies at diagnosis of IDDM was evaluated in 633 consecutively diagnosed Swedish diabetic patients aged 15-34 yr and in 282 volunteers of the same age. ICAs were present in 61% (383 of 633) of the patients and in 2% (5 of 282) of control subjects. When the initial classification was considered, ICAs were detected in 69% (327 of 473) of patients with IDDM, 23% (19 of 83) of those with NIDDM, 50% (36 of 72) of those with unclassifiable diabetes, and 20% (1 of 5) of those with secondary diabetes. The frequency of ICA fell significantly (P < 0.001) with age in IDDM patients from 77% (104/135) in those 15-19 yr old to 52% (50 of 96) in 30- to 34-yr-old IDDM patients. The low frequency of ICA in 30- to 34-yr-old IDDM patients was confined to men (42%, 28 of 66). The frequency of gastric (H+, K+-ATPase) antibodies was significantly (P < 0.05) higher in IDDM patients (10%, 47 of 449) than in patients with NIDDM (3%, 3 of 80) and unclassifiable diabetes (4%, 3 of 72). In conclusion, the frequency of ICA at the diagnosis of IDDM in young adult subjects decreases with increasing age, particularly in men. The frequent finding of ICA in patients considered to have NIDDM or unclassifiable diabetes indicates that misclassification of diabetes is frequent in young adult patients recently diagnosed with diabetes.
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| 8. |
- Riise, Gerdt C., 1956, et al.
(författare)
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Bronchiolitis obliterans syndrome in lung transplant recipients is associated with increased neutrophil activity and decreased antioxidant status in the lung
- 1998
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Ingår i: Eur Respir J. - 0903-1936. ; 12:1, s. 82-8
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Tidskriftsartikel (refereegranskat)abstract
- Long-term survival of lung transplant recipients is limited by the advent of obliterative bronchiolitis and irreversible airways obstruction, e.g. bronchiolitis obliterans syndrome (BOS). This study investigated whether inflammatory cells and their activation markers were increased in bronchoalveolar lavage (BAL) and transbronchial biopsies (TBB) from patients with BOS. Levels of antioxidants in BAL fluid were also assessed. BAL fluid and TBB from six single-lung, two bilateral-lung, and five heart-lung transplanted patients with diagnosis of BOS were compared with 13 transplant recipients without BOS. BAL fluid levels of myeloperoxidase (MPO), eosinophil cationic protein (ECP) and interleukin (IL)-8 were used as markers for the activation and attraction of neutrophils and eosinophils, respectively. Immunohistochemical staining of TBB with monoclonal antibodies to MPO and ECP (EG2) was performed. Significantly increased BAL percentages of neutrophils and levels of MPO were found in patients with BOS. The findings correlated well with the degree of monoclonal staining for MPO in TBB. BAL levels of ECP and IL-8 were significantly increased in BOS patients. BAL concentrations of the water-soluble antioxidants ascorbate, urate and glutathione were generally lower in BOS patients. The results indicate that neutrophil infiltration and activation, as well as oxidative stress, may play a role in the development and/or progression of bronchiolitis obliterans syndrome. Markers for neutrophil activation could have a potential role in monitoring disease activity in patients with this syndrome.
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| 9. |
- Scherstén, Anders, et al.
(författare)
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Re-Os and U-Pb constraints on gold mineralisation events in the Meso- to Neoarchaean Storo greenstone belt, Storo, southern West Greenland
- 2012
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Ingår i: Precambrian Research. - : Elsevier BV. - 0301-9268. ; 200, s. 149-162
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Tidskriftsartikel (refereegranskat)abstract
- The Storo greenstone belt in Godthabsfjord, southern West Greenland consists of juxtaposed rock units of different age and origin, and hosts gold mineralisation that is associated with arsenopyrite along a contact between lithological units and along the axial plane of a large fold core. The age and origin of the gold is debatable, but in this paper, we present new arsenopyrite Re-Os and zircon U-Pb data to constrain the age of the Storo gold deposit. A 2.71 +/- 0.05 Ga arsenopyrite isochron and 2.707 +/- 0.008 Ga highly radiogenic arsenopyrite from a mineralisation along a rock contact, together with a 2.64 +/- 0.02 Ga arsenopyrite isochron along the axial plane of the fold core indicate a two-stage mineralisation process. While the 2.707 +/- 0.008 Ga highly radiogenic arsenopyrite provides firm support for an early mineralisation event, a mixing origin cannot yet be excluded for the 2.71 +/- 0.05 Ga isochron. The 2.64 +/- 0.02 Ga isochron is in perfect agreement with recent U-Pb zircon data (Nutman et al., 2007. Precambrian Research 159, 19-32) and these data are best explained by orogenic mineralisation during amphibolite facies metamorphism along structural weak planes. The initial Os-187/Os-188 value of 0.56 +/- 0.16 for the 2.64 +/- 0.02 Ga isochron indicates a crustal source for the metals, whereas the initial Os-187/Os-188 = -0.1 +/- 0.6 for the 2.71 +/- 0.05 Ga isochron remains unconstrained. Re-Os data are best explained by relatively short crustal residence times of less than 0.1 Ga, wherein the Os, and associated metals, were extracted from the mantle at a time younger than 2.8 Ga, and in which the 2.64 +/- 0.02 Ga stage formed by mobilisation of an earlier mineralisation. Detrital zircon constraints imply volcanism and sediment deposition for parts of the belt at <= 2.84 Ga and that these units were tectonically juxtaposed to similar to 3.05 Ga rocks within the belt. The units that were deposited <= 2.84 Ga record metamorphic zircon U-Pb ages of similar to 2.63 Ga, but evidence for 2.72 Ga metamorphism, which is ubiquitous in adjacent terranes, is lacking. (C) 2012 Elsevier B.V. All rights reserved.
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| 10. |
- Sedimbi, S. K., et al.
(författare)
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SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients
- 2007
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Ingår i: Genes Immun. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 8:6, s. 518-21
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Tidskriftsartikel (refereegranskat)abstract
- SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.
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