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Sökning: WFRF:(Schitter G.)

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  • Herbst, SA, et al. (författare)
  • Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
  • 2022
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 6226-
  • Tidskriftsartikel (refereegranskat)abstract
    • Cancer heterogeneity at the proteome level may explain differences in therapy response and prognosis beyond the currently established genomic and transcriptomic-based diagnostics. The relevance of proteomics for disease classifications remains to be established in clinically heterogeneous cancer entities such as chronic lymphocytic leukemia (CLL). Here, we characterize the proteome and transcriptome alongside genetic and ex-vivo drug response profiling in a clinically annotated CLL discovery cohort (n = 68). Unsupervised clustering of the proteome data reveals six subgroups. Five of these proteomic groups are associated with genetic features, while one group is only detectable at the proteome level. This new group is characterized by accelerated disease progression, high spliceosomal protein abundances associated with aberrant splicing, and low B cell receptor signaling protein abundances (ASB-CLL). Classifiers developed to identify ASB-CLL based on its characteristic proteome or splicing signature in two independent cohorts (n = 165, n = 169) confirm that ASB-CLL comprises about 20% of CLL patients. The inferior overall survival in ASB-CLL is also independent of both TP53- and IGHV mutation status. Our multi-omics analysis refines the classification of CLL and highlights the potential of proteomics to improve cancer patient stratification beyond genetic and transcriptomic profiling.
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  • Schmets, A.J.M., et al. (författare)
  • First-principles investigation of the multiple phases in bituminous materials : the case of asphaltene stacking
  • 2009
  • Ingår i: ADVANCED TESTING AND CHARACTERISATION OF BITUMINOUS MATERIALS. - Rhodes, Greece. ; , s. 143-150
  • Konferensbidrag (refereegranskat)abstract
    • The existence of a microstructure in bituminous materials can explain this materials tendency to self heal. By means of atomic force microscopy and small angle neutron scattering the existence of the microstructure is demonstrated once again. Then it is suggested that the observed microstructure may very well be a consequence of the aggregation of asphaltenic molecules (providing internal volumes with a low H/C-ratio). This is a rather unadventurous suggestion, because flocculation of asphaltenes costs the global oil industry millions of dollars per day. A model asphaltene (a coronene-like molecule) has been selected for calculating semi-empirically the tendency to form stacks. It was found that there is some tendency to cluster, but the effect is not strong enough to be responsible for the observed microstructure.
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