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Träfflista för sökning "WFRF:(Schleusener Viola) "

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Numrering	Referens	Omslagsbild	Hitta
1.	Ajileye, Adebisi, et al. (författare) Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays 2017 Ingår i: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 61:4 Tidskriftsartikel (refereegranskat)abstract In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% of multidrug-resistant tuberculosis strains in some settings.
2.	Heyckendorf, Jan, et al. (författare) What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi-and Extensively Drug-Resistant Tuberculosis 2018 Ingår i: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 62:2 Tidskriftsartikel (refereegranskat)abstract Rapid and accurate drug susceptibility testing (DST) is essential for the treatment of multi-and extensively drug-resistant tuberculosis (M/XDR-TB). We compared the utility of genotypic DST assays with phenotypic DST (pDST) using Bactec 960 MGIT or Lowenstein-Jensen to construct M/XDR-TB treatment regimens for a cohort of 25 consecutive M/XDR-TB patients and 15 possible anti-TB drugs. Genotypic DST results from Cepheid GeneXpert MTB/RIF (Xpert) and line probe assays (LPAs; Hain GenoType MTBDRplus 2.0 and MTBDRsl 2.0) and whole-genome sequencing (WGS) were translated into individual algorithmderived treatment regimens for each patient. We further analyzed if discrepancies between the various methods were due to flaws in the genotypic or phenotypic test using MIC results. Compared with pDST, the average agreement in the number of drugs prescribed in genotypic regimens ranged from just 49% (95% confidence interval [ CI], 39 to 59%) for Xpert and 63% (95% CI, 56 to 70%) for LPAs to 93% (95% CI, 88 to 98%) for WGS. Only the WGS regimens did not contain any drugs to which pDST showed resistance. Importantly, MIC testing revealed that pDST likely underestimated the true rate of resistance for key drugs (rifampin, levofloxacin, moxifloxacin, and kanamycin) because critical concentrations (CCs) were too high. WGS can be used to rule in resistance even in M/XDR strains with complex resistance patterns, but pDST for some drugs is still needed to confirm susceptibility and construct the final regimens. Some CCs for pDST need to be reexamined to avoid systematic false-susceptible results in low-level resistant isolates.
3.	Koeser, Claudio U., et al. (författare) Reply to Dookie et al., "Whole-Genome Sequencing To Guide the Selection of Treatment for Drug-Resistant Tuberculosis" 2018 Ingår i: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 62:8 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract n/a

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Typ av publikation: tidskriftsartikel (3)

Typ av innehåll: refereegranskat (2); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Schön, Thomas (3); Merker, Matthias (3); Moradigaravand, Dane ... (3); Schleusener, Viola (3); Parkhill, Julian (3); Niemann, Stefan (3); visa fler...; Peacock, Sharon J. (3); Andres, Soenke (2); Koeser, Claudio U. (2); Sturegård, Erik (2); Lange, Christoph (2); Heyckendorf, Jan (2); Olaru, Ioana D. (2); Beckert, Patrick (2); Kohl, Thomas A. (2); Hillemann, Doris (2); Ajileye, Adebisi (1); Alvarez, Nataly (1); Walker, Timothy M. (1); Akter, Suriya (1); Brown, Kerstin (1); Omar, Shaheed V. (1); Coll, Francesc (1); Huang, Hairong (1); Diel, Roland (1); Ismail, Nazir (1); de Jong, Bouke C. (1); Peto, Tim E. A. (1); Crook, Derrick W. (1); Robledo, Jaime (1); Grace Smith, E. (1); Andres, Sonke (1); Koser, Claudio U. (1); visa färre...

Lärosäte: Linköpings universitet (3); Lunds universitet (2); Karolinska Institutet (2)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (3)

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