| 1. |
- Ewald, Frida, 1982, et al.
(författare)
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The role of c-FLIP splice variants in urothelial tumours
- 2011
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Ingår i: Cell Death & Disease. - 2041-4889.
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Tidskriftsartikel (refereegranskat)abstract
- Deregulation of apoptosis is common in cancer and is often caused by overexpression of anti-apoptotic proteins in tumour cells. One important regulator of apoptosis is the cellular FLICE-inhibitory protein (c-FLIP), which is overexpressed, for example, in melanoma and Hodgkin's lymphoma cells. Here, we addressed the question whether deregulated c-FLIP expression in urothelial carcinoma impinges on the ability of death ligands to induce apoptosis. In particular, we investigated the role of the c-FLIP splice variants c-FLIP(long) (c-FLIP(L)) and c-FLIP(short) (c-FLIP(S)), which can have opposing functions. We observed diminished expression of the c-FLIP(L) isoform in urothelial carcinoma tissues as well as in established carcinoma cell lines compared with normal urothelial tissues and cells, whereas c-FLIP(S) was unchanged. Overexpression and RNA interference studies in urothelial cell lines nevertheless demonstrated that c-FLIP remained a crucial factor conferring resistance towards induction of apoptosis by death ligands CD95L and TRAIL. Isoform-specific RNA interference showed c-FLIP(L) to be of particular importance. Thus, urothelial carcinoma cells appear to fine-tune c-FLIP expression to a level sufficient for protection against activation of apoptosis by the extrinsic pathway. Therefore, targeting c-FLIP, and especially the c-FLIP(L) isoform, may facilitate apoptosis-based therapies of bladder cancer in otherwise resistant tumours.
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| 2. |
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| 3. |
- Meier, Stefan C., et al.
(författare)
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Access to the Bis-benzene Cobalt(I) Sandwich Cation and its Derivatives : Synthons for a “Naked” Cobalt(I) Source?
- 2018
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Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851. ; 57:30, s. 9310-9314
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis and structural characterization of the hitherto unknown parent Co(bz)2 + (bz=benzene) complex and several of its derivatives are described. Their synthesis starts either from a CoCO5 + salt, or directly from Co2(CO)8 and a Ag+ salt. Stability and solubility of these complexes was achieved by using the weakly coordinating anions (WCAs) [Al(ORF)4]− and [F{Al(ORF)3}2]− {RF=C(CF3)3} and the solvent ortho-difluorobenzene (o-DFB). The magnetic properties of Co(bz)2 + were measured and compared in the condensed and gas phases. The weakly bound Co(o-dfb)2 + salts are of particular interest for the preparation of further CoI salts, for example, the structurally characterized low-coordinate 12 valence electron Co(PtBu3)2 + and Co(NHC)2 + salts.
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| 4. |
- Sánchez-Cano, Beatriz, et al.
(författare)
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Solar Energetic Particle Events Detected in the Housekeeping Data of the European Space Agency's Spacecraft Flotilla in the Solar System
- 2023
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Ingår i: Space Weather. - : American Geophysical Union (AGU). - 1542-7390. ; 21:8
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Tidskriftsartikel (refereegranskat)abstract
- Despite the growing importance of planetary Space Weather forecasting and radiation protection for science and robotic exploration and the need for accurate Space Weather monitoring and predictions, only a limited number of spacecraft have dedicated instrumentation for this purpose. However, every spacecraft (planetary or astronomical) has hundreds of housekeeping sensors distributed across the spacecraft, some of which can be useful to detect radiation hazards produced by solar particle events. In particular, energetic particles that impact detectors and subsystems on a spacecraft can be identified by certain housekeeping sensors, such as the Error Detection and Correction (EDAC) memory counters, and their effects can be assessed. These counters typically have a sudden large increase in a short time in their error counts that generally match the arrival of energetic particles to the spacecraft. We investigate these engineering datasets for scientific purposes and perform a feasibility study of solar energetic particle event detections using EDAC counters from seven European Space Agency Solar System missions: Venus Express, Mars Express, ExoMars-Trace Gas Orbiter, Rosetta, BepiColombo, Solar Orbiter, and Gaia. Six cases studies, in which the same event was observed by different missions at different locations in the inner Solar System are analyzed. The results of this study show how engineering sensors, for example, EDAC counters, can be used to infer information about the solar particle environment at each spacecraft location. Therefore, we demonstrate the potential of the various EDAC to provide a network of solar particle detections at locations where no scientific observations of this kind are available.
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| 5. |
- Wackerbarth, Ines, et al.
(författare)
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Cu-II Complexes and Coordination Polymers with Pyridine or Pyrazine Amides and Amino Benzamides-Structures and EPR Patterns
- 2020
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Ingår i: Inorganics. - : MDPI. - 2304-6740. ; 8:12
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Tidskriftsartikel (refereegranskat)abstract
- Isonicotine amide, picoline amide, pyrazine 2-amide, 2- and 4-amino benzamides and various Cu-II salts were used to target Cu-II complexes of these ligands alongside with 1D and 2D coordination polymers. Under the criterion of obtaining crystalline and single phased materials a number of new compounds were reliably reproduced. Remarkably, for some of these compounds the ideal Cu:ligand ratio of the starting materials turned out to be very different from Cu:ligand ratio in the products. Crystal and molecular structures from single-crystal XRD were obtained for all new compounds; phase purity was checked using powder XRD. We observed exclusively the O-amide and not the NH2amide function binding to Cu-II. In most of the cases; this occurred in chelates with the second pyridine, pyrazine or aminophenyl N function. mu-O,N ditopic bridging was frequently observed for the N = pyridine, pyrazine or aminophenyl functions, but not exclusively. The geometry around Cu-II in these compounds was very often axially elongated octahedral or square pyramidal. X-band EPR spectra of powder samples revealed various spectral symmetry patterns ranging from axial over rhombic to inverse axial. Although the EPR spectra cannot be unequivocally correlated to the observed geometry of Cu-II in the solid state structures, the EPR patterns can help to support assumed structures as shown for the compound [Cu(Ina)(2)Br-2] (Ina = isonicotine amide). As UV-vis absorption spectroscopy and magnetic measurement in the solid can also be roughly correlated to the surrounding of Cu-II, we suggest the combination of EPR, UV-vis spectroscopy and magnetic measurements to elucidate possible structures of Cu-II compounds with such ligands.
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