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- Rangarajan, Sathyanarayanan, et al.
(författare)
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V2C : A secure vehicle to cloud framework for virtualized and on-demand service provisioning
- 2012
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Ingår i: ICACCI '12 Proceedings of the International Conference on Advances in Computing, Communications and Informatics. - New York, NY, USA : ACM. - 9781450311960 ; , s. 148-154
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Konferensbidrag (refereegranskat)abstract
- Cloud computing has revolutionized the IT industry by enabling a virtualized resource provisioning model for organizations. The Network-as-a-Service (NaaS) provisioning model enables new ways of providing virtually isolated and on-demand networking capabilities in existing cloud provisioning models, resulting in best-effort performance, scalable data throughput, reduced latency, and reduced configuration complexity. In this paper we propose V2C, an elastic Vehicle-to-Cloud infrastructure that integrates NaaS into the automotive ecosystem and enables provisioning of vehicle-based services for automobile users. However, V2C introduces various security challenges and the main objective of this paper is to propose a secure provisioning model to address them.
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| 2. |
- Teuscher, Alina C., et al.
(författare)
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Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans
- 2024
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role of ECM composition changes in healthy aging remains unclear. Here we perform proteomics and in-vivo monitoring to systematically investigate ECM composition (matreotype) during aging in C. elegans revealing three distinct collagen dynamics. Longevity interventions slow age-related collagen stiffening and prolong the expression of collagens that are turned over. These prolonged collagen dynamics are mediated by a mechanical feedback loop of hemidesmosome-containing structures that span from the exoskeletal ECM through the hypodermis, basement membrane ECM, to the muscles, coupling mechanical forces to adjust ECM gene expression and longevity via the transcriptional co-activator YAP-1 across tissues. Our results provide in-vivo evidence that coordinated ECM remodeling through mechanotransduction is required and sufficient to promote longevity, offering potential avenues for interventions targeting ECM dynamics.
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