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- Eriksson, LE, et al.
(författare)
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Lipoatrophy of the footpad in HIV-treated patients is associated with increased PAI-1
- 2011
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Ingår i: Biological research for nursing. - : SAGE Publications. - 1552-4175 .- 1099-8004. ; 13:1, s. 89-96
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To describe lipoatrophy of the plantar pedis fat pads in human immunodeficiency virus (HIV) patients with or without long-term antiretroviral therapy (ART); to compare the characteristics of ART patients with and without plantar pedis lipoatrophy; and to examine the effects of HIV and metabolic/cardiovascular risk parameters and treatment history on plantar pedis lipoatrophy. Design: Participants included 134 patients who started protease inhibitors in antiretroviral therapy (ART) in 1996 and 49 treatment-naive patients, recruited in 2004. Participants were examined and graded for lipoatrophy of five body compartments including the plantar fat pads. Baseline HIV- and ART-related factors were documented together with follow-up metabolic/ cardiovascular risk parameters. Results: Plantar pedis lipoatrophy occurred more often among ART patients (60%) than among treatment-naive patients (12%; p < .001). ART patients with plantar lipoatrophy were older, had higher plasminogen activator inhibitor 1 (PAI-1) values, a higher prevalence of lipoatrophy in other body compartments, and longer stavudine and didanosine treatment history as compared to patients without plantar lipoatrophy. Multiple logistic regression modeling revealed that among the metabolic/cardiovascular parameters, increased PAI-1 was strongly and positively associated with plantar lipoatrophy. Among the treatment history parameters, didanosine was the strongest independent predictor for plantar lipoatrophy. Increased PAI-1 was not associated to lipoatrophy in any other location. Conclusions: Plantar lipoatrophy is common among patients on long-term ART and, though often overlooked, may cause significant discomfort. The association to PAI-1, a well-known marker of increased cardiovascular risk, is intriguing and places further focus on the need for an active approach to evaluating and lowering cardiovascular risk factors in long-term HIV treatment.
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- Schonnesson, LN, et al.
(författare)
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Coping modes with HIV disease predict loss from HIV study cohort
- 2005
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Ingår i: International journal of STD & AIDS. - : SAGE Publications. - 0956-4624 .- 1758-1052. ; 16:7, s. 479-481
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this longitudinal study of 41 Swedish men with HIV disease was to assess what variables or combination of variables might predict loss to retention at 12 months. The variables of focus were of patients' characteristics, quality of life, psychological, and medical characters. It appears that it is psychological variables relating to coping with HIV disease that are the best predictors of failure to retain respondents in this cohort. The responses to two items: 'I have been doing things that I believe will improve my health (e.g. changed my diet)' and 'I feel like giving up' correctly classified over 85% of cases lost to the study. These findings are worthy of replication and may prove useful in maximizing retention rates in longitudinal studies of the course of HIV disease and medication adherence and outcome.
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