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- Hess, Timo, et al.
(författare)
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Dissecting the genetic heterogeneity of gastric cancer
- 2023
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 92
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Tidskriftsartikel (refereegranskat)abstract
- Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture.Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO.Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level.Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular mechanisms underlying cardia GC and OAC/BO.
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| 4. |
- Geisler, Ursula, et al.
(författare)
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Musik baut Brücken? Über Bedingungen und Schwierigkeiten transnationaler Kulturforschung
- 2010
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Ingår i: Vom alten Norden zum neuen Europa: Politische Kultur im Ostseeraum. Festschrift für Bernd Henningsen. - 9783830517818 ; , s. 409-422
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This contribution deals with the topic of transnationalism as it has developed in the humanities in the last two decades. The starting point for the reflections is the author's experiences over the course of two research projects in the years 1996 to 2003. "Musik baut Brücken?" seeks to highlight some of the definitions and difficulties of "transnationalism" which have become obvious in several debates and in research projects. Employing illuminating, empirical examples, this text pays particular attention to music, folk songs and community singing from a Swedish-German perspective.
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- Haettner Aurelius, Eva, et al.
(författare)
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Transcendensens metaforer. En jeanpaulsk tradition i svensk dikt
- 2018
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Ingår i: Schriftfest | Festschrift für Annegret Heitmann. - 9783831646890 ; 33, s. 370-389
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Bokkapitel (refereegranskat)abstract
- En specifik typ av metaforer i svensk dikt, där ord för triviala ting krockar med ord för höga, abstrakta ting härleds till den tyske diktaren Jean Paul (1763 - 1825), och visas i Tegnérs, C F Dahlgrens, E A Karlfeldts, Birger Sjöbergs och Tomas Tranströmer dikter. Metafortypen är förbunden med en teologisk idé om metaforens möjlighet att överskrida gränsen mellan det jordiska och det himmelska.
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- Hockenjos, Vreni, 1972-
(författare)
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Picturing Dissolving Views : August Strindberg and the Visual Media of His Age
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The subject of this study is August Strindberg’s interaction with the visual media of his day. Its dual aim is to examine Strindberg’s work in the light of media history and to allow Strindberg’s work in turn to illuminate the media history of the fin de siècle. Taking its cue from the commonplace scholarly observation that Strindberg’s drama, particularly that of his later phase, is strikingly “cinematic”, it asks: What do such comparisons really tell us about Strindberg’s art and what, if anything, do they tell us about cinema?The thesis of this study is that the putatively “cinematic” style of Strindberg’s writings can only be understood against the backdrop of a mass culture, oriented towards the visual sense, which was undergoing rapid expansion at the turn of the last century. In devising his “dream play techniques”, it argues, Strindberg both drew on and reacted against various image-based modes of representation that had become extremely widespread in the late nineteenth century. The loss of reality that is so prominent a feature of works such as To Damascus (1898) or A Dream Play (1901) should in this sense be regarded as marked by an experience of mediatization, that is, the steady incorporation of all aspects of daily life by mass media technologies. Shifting the spotlight away from cinema, a critical encounter with Strindberg’s work can cast light on largely overlooked media practices such as magic lantern or Sciopticon exhibition, panoramic entertainments, instantaneous photography, and the introduction of the halftone process in printing. At the same time as it unsettles received notions of Strindberg’s drama as “cinematic”, the study seeks to show how the writings of this revolutionary artist can provide fresh material for a reassessment of life in a media-saturated age.
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- Mattsson, Niklas, 1979, et al.
(författare)
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The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
- 2011
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Ingår i: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 7:4
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Tidskriftsartikel (refereegranskat)abstract
- The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within laboratories. The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and identify sources of variability. In this article, we present the results from the first two rounds of the program.
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- Schröder, Stephan, 1979-
(författare)
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Towards Unconventional Applications of Wire Bonding
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis presents novel heterogeneous integration approaches of wire materials to fabricated and package MEMS devices by exploring unconventional applications of wire bonding technology. Wire bonding, traditionally endemic in the realm of device packaging to establish electrical die-to-package interconnections, is an attractive back-end technology, offering promising features, such as high throughput, flexibility and placement accuracy. Exploiting the advantages of state-of-the-art wire bonding technology and substitute the conventional micro welding approach with an innovative attachment concept, a generic integration platform for a multitude of wire materials is provided. This facilitates a cost-efficient and selective integration, which involves the attachment and shaping of a variety of intrinsically non-bondable wire materials. Furthermore, the selective integration of wire materials provides a simple method to generate complex suspended geometries, which circumvents the need for subsequent processing. The first part of this thesis reports of the integration of non-bondable shape memory alloy wires on wafer-level, which has led to an innovative method to fabricate micro actuators. Moreover, the integration of high performance resistive heating wires on chip-level is utilized to fabricate filament based infrared emitters, targeting non-dispersive infrared gas sensing of alcohol for automotive applications. In the second part, a series of unconventional applications of wire integration using the traditional thermo-sonic wire bonding approach is presented. A novel and low-cost nitric oxide gas sensor is realized by producing vertical bond wires featuring high aspect ratio. Next, the high placement accuracy of wire bonding tools is leveraged to integrate conductive metals cores for fabricating high aspect ratio through silicon vias. Finally, an advanced packaging approach for stress-sensitive MEMS gyroscopes is evaluated, which exclusively utilizes bond wires for realizing the die attachment.
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