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Sökning: WFRF:(Schultz Ralf)

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1.
  • Bauer, Juergen M., et al. (författare)
  • Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study : A Randomized, Double-Blind, Placebo-Controlled Trial
  • 2015
  • Ingår i: Journal of the American Medical Directors Association. - : Elsevier BV. - 1525-8610 .- 1538-9375. ; 16:9, s. 740-747
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Age-related losses of muscle mass, strength, and function (sarcopenia) pose significant threats to physical performance, independence, and quality of life. Nutritional supplementation could positively influence aspects of sarcopenia and thereby prevent mobility disability. Objective: To test the hypothesis that a specific oral nutritional supplement can result in improvements in measures of sarcopenia. Design: A multicenter, randomized, controlled, double-blind, 2 parallel-group trial among 380 sarcopenic primarily independent-living older adults with Short Physical Performance Battery (SPPB; 0-12) scores between 4 and 9, and a low skeletal muscle mass index. The active group (n = 184) received a vitamin D and leucine-enriched whey protein nutritional supplement to consume twice daily for 13 weeks. The control group (n = 196) received an iso-caloric control product to consume twice daily for 13 weeks. Primary outcomes of handgrip strength and SPPB score, and secondary outcomes of chair-stand test, gait speed, balance score, and appendicular muscle mass (by DXA) were measured at baseline, week 7, and week 13 of the intervention. Results: Handgrip strength and SPPB improved in both groups without significant between-group differences. The active group improved more in the chair-stand test compared with the control group, between-group effect (95% confidence interval): -1.01 seconds (-1.77 to -0.19), P = .018. The active group gained more appendicular muscle mass than the control group, between-group effect: 0.17 kg (0.004-0.338), P = .045. Conclusions: This 13-week intervention of a vitamin D and leucine-enriched whey protein oral nutritional supplement resulted in improvements in muscle mass and lower-extremity function among sarcopenic older adults. This study shows proof-of-principle that specific nutritional supplementation alone might benefit geriatric patients, especially relevant for those who are unable to exercise. These results warrant further investigations into the role of a specific nutritional supplement as part of a multimodal approach to prevent adverse outcomes among older adults at risk for disability.
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2.
  • Schultz, Daniel, et al. (författare)
  • EU FP6 IST-2003-507581 WINNER, D3.5 Proposal of the best Suited Deployment Concepts for the identified Scenarios and related RAN Protocols, Dec 2005
  • 2005
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • D3.5 presents relaying as an integral part of the WINNER system concept. The relay baseddeployment concept allows deploying the WINNER broadband radio interface cost efficiently. Suitableassumptions have been made on the technical solutions as guideline for the definition of protocolrequirements. The relay is presented as part of the overall WINNER system concept in the WINNERlogical nodes architecture. Further the logical nodes architecture and the relation between functions insystem layers and specific logical nodes is shown. Protocols and functions are presented that arenecessary to implement relaying in the WINNER system concept. Therefore the protocols of differentlayers namely the radio resource control layer, the radio link control layer and the medium access controllayer have been investigated in more detail, also under consideration of the physical layer aspects. Inaddition to that two add-on solutions to increase the efficiency of relay based technologies have beeninvestigated and are described. These add-ons are cooperative relaying and mobile relays.
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