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Träfflista för sökning "WFRF:(Schumann Carina) "

Sökning: WFRF:(Schumann Carina)

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1.
  • de Oliveira e Silva, Jose Claudio, et al. (författare)
  • EMC considerations for JLRL direct lightning current measurement
  • 2022
  • Ingår i: 2022 36Th International Conference On Lightning Protection (ICLP 2022). - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 26-31
  • Konferensbidrag (refereegranskat)abstract
    • In this paper the electromagnetic compatibility (EMC) considerations made to the direct lightning current measuring system that is part of the Johannesburg Lightning Research Laboratory (JLRL) are presented. The output voltages from two series connected shunts and the sending of their analog signals downward a tower to the measuring system, makes this measuring setup particularly critical regarding immunity against the strong effects of the lightning current.
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2.
  • Hess, Timo, et al. (författare)
  • Dissecting the genetic heterogeneity of gastric cancer
  • 2023
  • Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 92
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture.Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO.Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level.Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular mechanisms underlying cardia GC and OAC/BO. 
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3.
  • Saba, Marcelo, et al. (författare)
  • The study of lightning strikes to common buildings in Brazil
  • 2016
  • Konferensbidrag (refereegranskat)abstract
    • Most of what is known about the electric current of downward flashes and striking distance of lightning protection systems come from information gathered on tall towers. There are no observational data of lightning attachment to common structures or buildings (under 60 m) that are present in almost every city. In order to study lightning strikes to common buildings, several instruments were installed in and around two identical buildings located in São Paulo city, Brazil. This paper describes the setup of electric field sensors, current transformers, X-ray sensors, high-speed video and standard video cameras. Some of the data already obtained in its first two months of operation are also shown.
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