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- Di Baldassarre, Giuliano, et al.
(författare)
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Flood-plain mapping : a critical discussion of deterministic and probabilistic approaches
- 2010
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Ingår i: Hydrological Sciences Journal. - : Informa UK Limited. - 0262-6667 .- 2150-3435. ; 55:3, s. 364-376
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Tidskriftsartikel (refereegranskat)abstract
- Different methodologies for flood-plain mapping are analysed and discussed by comparing deterministic and probabilistic approaches using hydrodynamic numerical solutions. In order to facilitate the critical discussion, state-of-art techniques in the field of flood inundation modelling are applied to a specific test site (River Dee, UK). Specifically, different flood-plain maps are derived for this test site. A first map is built by applying an advanced deterministic approach: use of a fully two-dimensional finite element model (TELEMAC-2D), calibrated against a historical flood extent, to derive a 1-in-100 year flood inundation map. A second map is derived by using a probabilistic approach: use of a simple raster-based inundation model (LISFLOOD-FP) to derive an uncertain flood extent map predicting the 1-in-100 year event conditioned on the extent of the 2006 flood. The flood-plain maps are then compared and the advantages and disadvantages of the two different approaches are critically discussed.
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| 3. |
- Gobeyn, Sacha, et al.
(författare)
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Impact of the timing of a SAR image acquisition on the calibration of a flood inundation model
- 2017
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Ingår i: Advances in Water Resources. - : ELSEVIER SCI LTD. - 0309-1708 .- 1872-9657. ; 100, s. 126-138
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Tidskriftsartikel (refereegranskat)abstract
- Synthetic Aperture Radar (SAR) data have proven to be a very useful source of information for the calibration of flood inundation models. Previous studies have focused on assigning uncertainties to SAR images in order to improve flood forecast systems (e.g. Giustarini et al. (2015) and Stephens et al. (2012)). This paper investigates whether the timing of a SAR acquisition of a flood has an important impact on the calibration of a flood inundation model. As no suitable time series of SAR data exists, we generate a sequence of consistent SAR images through the use of a synthetic framework. This framework uses two available ERS-2 SAR images of the study area, one taken during the flood event of interest, the second taken during a dry reference period. The obtained synthetic observations at different points in time during the flood event are used to calibrate the flood inundation model. The results of this study indicate that the uncertainty of the roughness parameters is lower when the model is calibrated with an image taken before rather than during or after the flood peak. The results also show that the error on the modelled extent is much lower when the model is calibrated with a pre-flood peak image than when calibrated with a near-flood peak or a post-flood peak image. It is concluded that the timing of the SAR image acquisition of the flood has a clear impact on the model calibration and consequently on the precision of the predicted flood extent.
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| 4. |
- Hudson, Lawrence N, et al.
(författare)
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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
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Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
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Tidskriftsartikel (refereegranskat)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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| 5. |
- Hulpia, Fabian, et al.
(författare)
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Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
- 2019
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- African trypanosomiasis is a disease caused by Trypanosoma brucei parasites with limited treatment options. Trypanosoma is unable to synthesize purines de novo and relies solely on their uptake and interconversion from the host, constituting purine nucleoside analogues a potential source of antitrypanosomal agents. Here we combine structural elements from known trypanocidal nucleoside analogues to develop a series of 3'-deoxy-7-deazaadenosine nucleosides, and investigate their effects against African trypanosomes. 3'-Deoxytubercidin is a highly potent trypanocide in vitro and displays curative activity in animal models of acute and CNS-stage disease, even at low doses and oral administration. Whole-genome RNAi screening reveals that the P2 nucleoside transporter and adenosine kinase are involved in the uptake and activation, respectively, of this analogue. This is confirmed by P1 and P2 transporter assays and nucleotide pool analysis. 3'-Deoxytubercidin is a promising lead to treat late-stage sleeping sickness.
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| 6. |
- Wittchen, Hans-Ulrich, et al.
(författare)
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The need for a behavioural science focus in research on mental health and mental disorders
- 2014
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Ingår i: International Journal of Methods in Psychiatric Research. - : Wiley-Blackwell. - 1049-8931 .- 1557-0657. ; 23, s. 28-40
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Tidskriftsartikel (refereegranskat)abstract
- Psychology as a science offers an enormous diversity of theories, principles, and methodological approaches to understand mental health, abnormal functions and behaviours and mental disorders. A selected overview of the scope, current topics as well as strength and gaps in Psychological Science may help to depict the advances needed to inform future research agendas specifically on mental health and mental disorders. From an integrative psychological perspective, most maladaptive health behaviours and mental disorders can be conceptualized as the result of developmental dysfunctions of psychological functions and processes as well as neurobiological and genetic processes that interact with the environment. The paper presents and discusses an integrative translational model, linking basic and experimental research with clinical research as well as population-based prospective-longitudinal studies. This model provides a conceptual framework to identify how individual vulnerabilities interact with environment over time, and promote critical behaviours that might act as proximal risk factors for ill-health and mental disorders. Within the models framework, such improved knowledge is also expected to better delineate targeted preventive and therapeutic interventions that prevent further escalation in early stages before the full disorder and further complications thereof develop. In contrast to conventional personalized medicine that typically targets individual (genetic) variation of patients who already have developed a disease to improve medical treatment, the proposed framework model, linked to a concerted funding programme of the Science of Behaviour Change, carries the promise of improved diagnosis, treatment and prevention of health-risk behaviour constellations as well as mental disorders.
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| 7. |
- Yan, Kun, et al.
(författare)
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A review of low-cost space-borne data for flood modelling : topography, flood extent and water level
- 2015
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Ingår i: Hydrological Processes. - : Wiley. - 0885-6087 .- 1099-1085. ; 29:15, s. 3368-3387
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Forskningsöversikt (refereegranskat)abstract
- During the last two decades, remote sensing data have led to tremendous progress in advancing flood inundation modelling. In particular, low-cost space-borne data can be invaluable for large-scale flood studies in data-scarce areas. Various satellite products yield valuable information such as land surface elevation, flood extent and water level, which could potentially contribute to various flood studies. An increasing number of research studies have been dedicated to exploring those low-cost data towards building, calibration and evaluation, and remote-sensed information assimilation into hydraulic models. This paper aims at reviewing these recent scientific efforts on the integration of low-cost space-borne remote sensing data with flood modelling. Potentials and limitations of those data in flood modelling are discussed. This paper also introduces the future satellite missions and anticipates their likely impacts in flood modelling.
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