| 1. |
- Comai, Glenda Evangelina, et al.
(författare)
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Local retinoic acid signaling directs emergence of the extraocular muscle functional unit
- 2020
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Ingår i: PLoS biology. - : Public Library Science. - 1544-9173 .- 1545-7885. ; 18:11
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Tidskriftsartikel (refereegranskat)abstract
- Coordinated development of muscles, tendons, and their attachment sites ensures emergence of functional musculoskeletal units that are adapted to diverse anatomical demands among different species. How these different tissues are patterned and functionally assembled during embryogenesis is poorly understood. Here, we investigated the morphogenesis of extraocular muscles (EOMs), an evolutionary conserved cranial muscle group that is crucial for the coordinated movement of the eyeballs and for visual acuity. By means of lineage analysis, we redefined the cellular origins of periocular connective tissues interacting with the EOMs, which do not arise exclusively from neural crest mesenchyme as previously thought. Using 3D imaging approaches, we established an integrative blueprint for the EOM functional unit. By doing so, we identified a developmental time window in which individual EOMs emerge from a unique muscle anlage and establish insertions in the sclera, which sets these muscles apart from classical muscle-to-bone type of insertions. Further, we demonstrate that the eyeballs are a source of diffusible all-trans retinoic acid (ATRA) that allow their targeting by the EOMs in a temporal and dose-dependent manner. Using genetically modified mice and inhibitor treatments, we find that endogenous local variations in the concentration of retinoids contribute to the establishment of tendon condensations and attachment sites that precede the initiation of muscle patterning. Collectively, our results highlight how global and site-specific programs are deployed for the assembly of muscle functional units with precise definition of muscle shapes and topographical wiring of their tendon attachments.
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| 2. |
- Kuzuhara, Masayuki, et al.
(författare)
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Gliese 12 b: A Temperate Earth-sized Planet at 12 pc Ideal for Atmospheric Transmission Spectroscopy
- 2024
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Ingår i: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 969:1
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Tidskriftsartikel (refereegranskat)abstract
- Recent discoveries of Earth-sized planets transiting nearby M dwarfs have made it possible to characterize the atmospheres of terrestrial planets via follow-up spectroscopic observations. However, the number of such planets receiving low insolation is still small, limiting our ability to understand the diversity of the atmospheric composition and climates of temperate terrestrial planets. We report the discovery of an Earth-sized planet transiting the nearby (12 pc) inactive M3.0 dwarf Gliese 12 (TOI-6251) with an orbital period (P(or)b) of 12.76 days. The planet, Gliese 12 b, was initially identified as a candidate with an ambiguous P-orb from TESS data. We confirmed the transit signal and P-orb using ground-based photometry with MuSCAT2 and MuSCAT3, and validated the planetary nature of the signal using high-resolution images from Gemini/NIRI and Keck/NIRC2 as well as radial velocity (RV) measurements from the InfraRed Doppler instrument on the Subaru 8.2 m telescope and from CARMENES on the CAHA 3.5 m telescope. X-ray observations with XMM-Newton showed the host star is inactive, with an X-ray-to-bolometric luminosity ratio of log L-X/L-bol approximate to - 5.7. Joint analysis of the light curves and RV measurements revealed that Gliese 12 b has a radius of 0.96 +/- 0.05 R-circle plus, a 3 sigma mass upper limit of 3.9M(circle plus), and an equilibrium temperature of 315 +/- 6 K assuming zero albedo. The transmission spectroscopy metric (TSM) value of Gliese 12 b is close to the TSM values of the TRAPPIST-1 planets, adding Gliese 12 b to the small list of potentially terrestrial, temperate planets amenable to atmospheric characterization with JWST.
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| 3. |
- Sordo, Rosanna, et al.
(författare)
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Stellar libraries for Gaia
- 2011
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Ingår i: Journal of Physics, Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 328:Conference 1, s. 012006-
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Tidskriftsartikel (refereegranskat)abstract
- Gaia will observe up to a billion stellar sources. Automated algorithms are under development to derive the atmospheric parameters of all observed spectra, from low resolution optical spectra alone or in synergy with high resolution spectra in the near-IR Ca II triplet region. To do so, a large database of state-of-the-art stellar libraries has been produced for the Gaia community, computed using different codes optimized for specific purposes. The choice to use different spectral codes in different regions of the H-R diagram raises the problem of the coherence of the different spectra, specifically in the transition zones. We present a comparison between the libraries from the point of view of spectra simulations for training the Gaia algorithms. We also present the implementation of these libraries into a Simple Stellar Population code.
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| 4. |
- Sordo, Rosanna, et al.
(författare)
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Synthetic stellar and SSP libraries as templates for Gaia simulations
- 2010
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Ingår i: Astrophysics and Space Science. - : Springer Science and Business Media LLC. - 0004-640X .- 1572-946X. ; 328:1-2, s. 331-335
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Tidskriftsartikel (refereegranskat)abstract
- ESA's Gaia mission will collect low resolution spectroscopy in the optical range for 109 objects. Complete and up-to-date libraries of synthetic stellar spectra are needed to built algorithms aimed to automatically derive the classification and the parametrization of this huge amount of data. In addition, libraries of stellar spectra are one of the main ingredients of stellar population synthesis models, aiming to derive the properties of unresolved stellar populations from their integrated light. We present (a) the newly computed libraries of synthetic spectra built by the Gaia community, covering the whole optical range (300-1100 nm) at medium-high resolution of (0.3 nm) for stars spanning the most different types, from M to O, from A-peculiar to Emission lines to White Dwarfs, and (b) the implementation of those libraries in our SSP code (Tantalo in The Initial Mass Function 50 Years Later, 327:235 2005), exploring different stellar evolution models.
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