| 1. |
- Janik, Stefan, et al.
(författare)
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Using the serratus anterior free flap for dynamic facial reanimation : Systematic review
- 2023
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Ingår i: Head and Neck. - : John Wiley & Sons. - 1043-3074 .- 1097-0347. ; 45:1, s. 266-274
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Forskningsöversikt (refereegranskat)abstract
- It was the purpose of this study to evaluate the role of the serratus anterior free flap (SAFF) with its long thoracic nerve (LTN) as composite flap for dynamic facial reanimation. A total of 10 studies, published between 2004 and 2021, met inclusion criteria. Clinical data of 48 patients were used for the systematic review and analysis. One to three slips were used, mainly as one-stage procedures (n = 39; 81.3%), to create different force vectors. Single or double innervated muscle transfers were utilized in 32 (66.7%) and 16 (33.3%) cases with additionally harvested skin paddles in 4 (8.3%) patients. The LTN was mostly anastomosed to the ipsilateral masseteric nerve (45.8%; n = 22) or to remaining facial nerve branches (37.5%; n = 18), while cross-facial-nerve-grafting was rarely used (16.7%; n = 8). The SAFF as composite flap with different force vectors proved to be a good candidate for immediate dynamic facial reanimation after any midface defects.
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| 2. |
- Anzt, Hartwig, et al.
(författare)
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An environment for sustainable research software in Germany and beyond: current state, open challenges, and call for action
- 2020
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Ingår i: F1000 Research. - : F1000 Research Ltd. - 2046-1402. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Research software has become a central asset in academic research. It optimizes existing and enables new research methods, implements and embeds research knowledge, and constitutes an essential research product in itself. Research software must be sustainable in order to understand, replicate, reproduce, and build upon existing research or conduct new research effectively. In other words, software must be available, discoverable, usable, and adaptable to new needs, both now and in the future. Research software therefore requires an environment that supports sustainability. Hence, a change is needed in the way research software development and maintenance are currently motivated, incentivized, funded, structurally and infrastructurally supported, and legally treated. Failing to do so will threaten the quality and validity of research. In this paper, we identify challenges for research software sustainability in Germany and beyond, in terms of motivation, selection, research software engineering personnel, funding, infrastructure, and legal aspects. Besides researchers, we specifically address political and academic decision-makers to increase awareness of the importance and needs of sustainable research software practices. In particular, we recommend strategies and measures to create an environment for sustainable research software, with the ultimate goal to ensure that software-driven research is valid, reproducible and sustainable, and that software is recognized as a first class citizen in research. This paper is the outcome of two workshops run in Germany in 2019, at deRSE19 - the first International Conference of Research Software Engineers in Germany - and a dedicated DFG-supported follow-up workshop in Berlin.
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| 3. |
- Heyne, Stefan, 1979, et al.
(författare)
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Bio-SNG Production via Gasification - Process Integration Aspects for Improving Process Performance
- 2013
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Ingår i: Proceedings of the 21st European Biomass Conference and Exhbition. - 2282-5819. - 9788889407530 ; , s. 1291 - 1304
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Konferensbidrag (refereegranskat)abstract
- This paper presents results from a comprehensive process integration study of different process alternatives for Bio-SNG production based on biomass gasification. The influence of the different conversion steps in the process chain – drying, gasification, gas cleaning, methanation, and gas upgrade – on the overall process performance is investigated. Process bottlenecks as well as heat and material integration aspects are highlighted. Using future energy market scenarios, the energetic, economic, and carbon footprint performance of different process configurations are evaluated from a system perspective. About 63 MLHV of Bio-SNG can be produced from a process converting 100 MWth,LHV (20 wt-% moisture) of forestry residues. Drying of the feedstock from a natural moisture content of 50 wt-% using internal process heat recovery is shown to be important for increasing the process energy efficiency, while the choice of gasification and methanation technology is shown to be of minor importance from a process integration perspective. Amine-based CO2 separation for gas upgrade is shown to be preferable to membrane or pressure-swing adsorption based options both from an economic and Bio-SNG yield perspective. Production cost estimates in the range of 103–112 €2010/MWhSNG indicate that price parity with fossil natural gas would require specific and significant support policies.
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| 4. |
- Heyne, Stefan, 1979, et al.
(författare)
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Coal and biomass gasification for sng production
- 2016
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Ingår i: Synthetic Natural Gas from Coal and Dry Biomass, and Power?to?Gas Applications. - Hoboken, NJ, USA : John Wiley & Sons, Inc.. - 9781119191339 ; , s. 5-40
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Within the production of synthetic natural gas - basically methane-from solid feed stock such as coal or biomass the major conversion step is gasification, generating a product gas containing a mixture of permanent and condensable gases, as well as solid residues. The gasification step can be conducted in different atmospheres and using different reaction agents. This chapter discusses the role of gasification for the overall substitute natural gas (SNG) process, and the basic thermodynamic aspects within gasification. The gasification process is a series of different conversions involving both homogeneous and heterogeneous reactions. The basic steps from solid fuel to product gas are drying, pyrolysis, and gasification. From a technological viewpoint, there basically exist three different gasification reactor types that are used at large scale: fixed bed reactors, entrained flow reactors, and fluidized bed reactors. Coal is mainly used in entrained flow gasification or fixed bed units, whereas biomass gasification is mostly done in fluidized bed reactors. © 2016 by John Wiley & Sons, Inc. All rights reserved.
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| 5. |
- Heyne, Stefan, 1979, et al.
(författare)
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Integration study for alternative methanation technologies for the production of synthetic natural gas from gasified biomass
- 2010
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Ingår i: Chemical Engineering Transactions. - 2283-9216. ; 21, s. 409-414
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Konferensbidrag (refereegranskat)abstract
- This paper analyzes the integration of two different methanation technologies – fixed bed adiabatic and fluidised bed isothermal - in a SNG production process and the consequences for the overall process energy conversion performance. The different operating conditions of the two methanation technologies lead to a change in temperature levels and quantities of recoverable heat, respectively, but also to differences in the overall processes’ power consumption. Using pinch methodology for optimal internal heat recovery in combination with flowsheeting software (ASPEN Plus), the two methanation alternatives are fitted into the SNG production process. The potential power production from recovered process heat is analysed based on the Carnot efficiency and compared to the overall power consumption within the SNG process. Both methanation alternatives perform equally within the given boundary conditions, resulting in an output of SNG of 63.3 MWLHV per 100 MWLHV dry fuel input and a ratio of about 1.22 between theoretical power production and overall power consumption.
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| 6. |
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| 7. |
- Minocherhomjl, Sheroy, et al.
(författare)
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Sequence and expression analysis of gaps in human chromosome 20
- 2012
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Ingår i: Nucleic Acids Research. - : Oxford University Press. - 0305-1048 .- 1362-4962. ; 40:14, s. 6660-6672
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Tidskriftsartikel (refereegranskat)abstract
- The finished human genome-assemblies comprise several hundred un-sequenced euchromatic gaps, which may be rich in long polypurine/polypyrimidine stretches. Human chromosome 20 (chr 20) currently has three unfinished gaps remaining on its q-arm. All three gaps are within gene-dense regions and/or overlap disease-associated loci, including the DLGAP4 locus. In this study, we sequenced ~99% of all three unfinished gaps on human chr 20, determined their complete genomic sizes and assessed epigenetic profiles using a combination of Sanger sequencing, mate pair paired-end high-throughput sequencing and chromatin, methylation and expression analyses. We found histone 3 trimethylated at Lysine 27 to be distributed across all three gaps in immortalized B-lymphocytes. In one gap, five novel CpG islands were predominantly hypermethylated in genomic DNA from peripheral blood lymphocytes and human cerebellum. One of these CpG islands was differentially methylated and paternally hypermethylated. We found all chr 20 gaps to comprise structured non-coding RNAs (ncRNAs) and to be conserved in primates. We verified expression for 13 candidate ncRNAs, some of which showed tissue specificity. Four ncRNAs expressed within the gap at DLGAP4 show elevated expression in the human brain. Our data suggest that unfinished human genome gaps are likely to comprise numerous functional elements.
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