| 1. |
- Distler, J. H. W., et al.
(författare)
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Is there a role for TNF-alpha antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique
- 2011
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Ingår i: Clinical and Experimental Rheumatology. - 1593-098X. ; 29:2, s. 40-45
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To obtain experiences and expert opinion on treatment of SSc patients with TNF-alpha antagonists. Methods: An investigation was carried out among the EUSTAR centres into their expertise on use of TNF-alpha antagonists. Assessment forms on the frequency of TNF-alpha inhibitor use were distributed to EULAR Scleroderma Trials and Research Group (EUSTAR) centres. Afterwards, a three round Delphi exercise was performed to obtain expert consensus on the use of TNF-alpha inhibitors in SSc. Results: Seventy-nine centres returned information on use of TNF-alpha antagonists in SSc patients. A total of 65 patients were treated with TNF-alpha inhibitors in 14 different centres. Forty-eight of the 65 patients treated with TNF-alpha inhibitors improved. Improvement was mainly seen in patients with arthritis, whereas the effects on fibrosis varied. In the first round of the subsequent Delphi approach, 71 out of 79 experts stated that they would use TNF-alpha antagonists in SSc. Arthritis was suggested as an indication for TNF alpha antagonists by 75% of the experts. However; after the third stage of the Delphi exercise, the acceptance for the off-label use of TNF-alpha antagonists decreased and 59% recommended that TNF-alpha antagonists should not be used or only used in clinical trials in SSc patients, while 38% of the experts suggested the use of TNF-alpha antagonists for arthritis associated with SSc. Conclusions: Most of the experts do not recommend the routine use of TNF-alpha antagonists in systemic sclerosis. Arthritis might be a potential indication in SSc, although controlled clinical trials with TNF-alpha antagonists are needed before general recommendations can be given.
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| 2. |
- Kavas, H., et al.
(författare)
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CTAB-Mn3O4 nanocomposites : Synthesis, NMR and low temperature EPR studies
- 2010
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Ingår i: Polyhedron. - : Elsevier BV. - 0277-5387 .- 1873-3719. ; 29:5, s. 1375-1380
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Tidskriftsartikel (refereegranskat)abstract
- We are reporting on the synthesis of Mn3O4 nanoparticles and CTAB-Mn3O4 nanocomposites via a sonochemical route using MnCl2, ethanol, NaOH and CTAB. The crystalline phase was identified as Mn3O4. The crystallite size of the CTAB-Mn3O4 nanocomposite was identified as 13 +/- 5 nm from X-ray line profile fitting and the particle size from TEM was 107.5 +/- 1.4 nm. The interaction between CEAB and the Mn3O4 nanoparticles was investigated by FTIR and H-1 NMR spectroscopies. Two different magnetic phase transitions were observed for both samples below the Curie temperature (43 degrees C) by using a low temperature Electron Paramagnetic Resonance (EPR) technique. Also we determined the effect of the capping with CTAB on the reduction in absorbed power.
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| 4. |
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| 5. |
- Baykal, A., et al.
(författare)
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Acid Functionalized Multiwall Carbon Nanotube/Magnetite (MWCNT)-COOH/Fe3O4 Hybrid : Synthesis, Characterization and Conductivity Evaluation
- 2013
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Ingår i: Journal of Inorganic and Organometallic Polymers and Materials. - : Springer Science and Business Media LLC. - 1574-1443 .- 1574-1451. ; 23:3, s. 726-735
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Tidskriftsartikel (refereegranskat)abstract
- A functionalized multiwall carbon nanotube (MWCNT)-COOH/Fe3O4 hybrid was fabricated by co-precipitation method. Fe3O4 nanoparticles were stably attached to the surface of carboxyl groups (COOH). The presence of Fe3O4 nanoparticles and their surface conjugation to MWCNT have been confirmed by XRD, TEM and FT-IR techniques. Magnetic evaluation revealed a superparamagnetic character of the hybrid and therefore the attached Fe3O4 nanoparticles. The crystallite size (9 +/- A 3 nm), particle size (9 +/- A 2 nm) and magnetic domain size estimated for Fe3O4 are consistent with each other, which reveal the single crystalline character of the nanoparticles. Electrical conductivity and dielectric behavior have also been characterized by utilizing impedance spectroscopy up to 3 MHz for an isotherm line varying from 293 to 393 K by 10 K steps. Electrical characteristics and its complex dielectric approaches might be elucidated with the existence of a conventional tunneling conduction mechanism of temperature-independency. The AC conductivity of MWCNT-COOH/Fe3O4 hybrid could also be a consequence of the estimations of the universal dynamic response.
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| 6. |
- Baykal, A., et al.
(författare)
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Synthesis and Characterization of Dendrimer-Encapsulated Iron and Iron-Oxide Nanoparticles
- 2012
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Ingår i: JOURNAL OF SUPERCONDUCTIVITY AND NOVEL MAGNETISM. - : Springer Science and Business Media LLC. - 1557-1939 .- 1557-1947. ; 25:5, s. 1541-1549
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, a series of iron (Fe) containing nanoparticles were prepared by employing PAMAM (Poly(amidoamine), dendrimers with different generations (G0-G3) as templates and sodium borohydride as a reducing agent. The products have been characterized by TEM, FT-IR, XRD, VSM, TGA, and XPS. XRD analysis reveal low crystallinity of formed particles within the dendrimers, however, crystallinity of the nanoparticles was observed to increase with increasing generation of dendrimers. Dominant phases were determined as magnetite (Fe3O4 or maghemite, gamma-Fe2O3). XPS analysis revealed the chemical composition of nanoparticles as iron oxide which indicated the oxidation of Fe species subsequent to the reduction process, in agreement with XRD analysis. The magnetization curves have superparamagnetic nonhysteretic characteristic at lower fields and with nonsaturation characteristic at high fields. Magnetic evaluation of samples with the 20:1 molar ratio of Fe:PAMAM showed decreasing superparamagnetic character and decreasing saturation magnetisation with increasing generation of dendrimers.
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| 7. |
- Deligoz, H., et al.
(författare)
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Synthesis and characterization of poly(1-vinyltriazole)-grafted superparamagnetic iron oxide nanoparticles
- 2012
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Ingår i: Synthetic metals. - : Elsevier BV. - 0379-6779 .- 1879-3290. ; 162:7-8, s. 590-597
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Tidskriftsartikel (refereegranskat)abstract
- We reported on the synthesis and detailed physicochemical characterization of poly(1-vinyltriazole)-grafted iron oxide nanoparticles. Superparamagnetic iron oxide nanoparticles (SPION) were fabricated by gel-to-crystalline conversion method. Telomerization of poly(1-vinyltriazole) on iron oxide nanoparticles was achieved via silanization process. XRD analysis confirmed the crystalline phase as magnetite, and FT-IR analysis confirmed the presence of PVTri on nanoparticles. Particle morphology was observed to be polygonic, due to the synthesis process, while average size estimated from TEM micrographs is 7 nm. Agreement between crystallite size estimated from XRD and particle size from TEM affirms single crystalline character of these nanoparticles. Dependence of conductivity on temperature showed a strong evidence for thermally activated polarization mechanism. Temperature and frequency dependence of dielectric permittivity revealed interfacial polarization and temperature-assisted-reorganization effects. Magnetic evaluation showed non-saturation and superparamagnetic characteristics of nanoparticles as well as magnetic particles being single domains.
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| 8. |
- Dencker, Lennart, et al.
(författare)
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Position Paper : EUFEPS Network on Veterinary Medicines Initiative: An interdisciplinary forum to support Veterinary Pharmacology and promote the development of new pharmaceuticals for Animal Health
- 2016
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Ingår i: European Journal of Pharmaceutical Sciences. - 0928-0987 .- 1879-0720. ; 91, s. I-VII
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Tidskriftsartikel (refereegranskat)abstract
- Veterinary medicines account for a substantial portion of the production, sale, and consumption of medicines in Europe, and probably world-wide. This calls our attention to the fact that only healthy farm animals can ensure safe and sufficient livestock products to meet the growing demand for animal protein. Human and veterinary medicine share many common features - expressed and symbolised by the "One Health Concept". This concept forms the logical basis for the maintenance of healthy livestock by the control of zoonoses and foodborne diseases, the prevention of poor sanitary conditions, and the reduction of microbial and parasitic threats, including resistance to antibiotics and anti-parasitic drugs. Achieving these aims will require international cooperation and interdisciplinary action. A new initiative of the European Federation for Pharmaceutical Sciences (EUFEPS) - the Network on Veterinary Medicines - has the potential to manage and overcome these challenges. A number of EUFEPS expertise networks have already been established, and some will be instrumental in supporting the activities of the Network on Veterinary Medicines, e.g., the European Network on PharmacoGenomics Research and Implementation (EPRIN), as well as the Network on Bioavailability and Biopharmaceutics, and the envisioned Network on Systems Pharmacology. Notably, the EUFEPS Networks on Safety Sciences, on Environment and Pharmaceuticals and on NanoMedicine as well as on Regulatory Science, represent promising partners. New technologies are being introduced to veterinary medicine for the treatment of numerous and frequently species-specific conditions. Scientific input from different areas is required to evaluate the potential benefitrisk profiles of these novel products, drug delivery techniques, and medical attention for animals as a whole. Drug treatment of food-producing animals inevitably affects consumer safety and public health, as any administration of medicines to animals may result in the presence of drug residues in edible tissues or products such as milk, eggs, and honey. The many questions surrounding the risks to human health and to the environment posed by exposure to veterinary drug residues cause great concern among health authorities as well as the public. In particular, the shared use of many classes of antimicrobials in both veterinary and human medicine, the emergence and spread of resistant microbes from animals or animal-derived products to humans, and the presence of contaminated manure in the environment are all provoking deep concern throughout the world. The Network on Veterinary Medicines initiative sees itself as broadly positioned. Among its most important goals are contributing to legislative issues in veterinary medicine and to the development of new pharmaceuticals for animal health, including novel drug delivery systems. Efforts to support the academic teaching and training of veterinary professionals and formulators for veterinary drug delivery are also considered imperative objectives of the network. The pursuit of these tasks will depend on interdisciplinary cooperation among experts from pharmaceutical and veterinary sciences, concentrating on issues where scientists from academia, industry and regulatory agencies can collaborate. National and international healthcare bodies, as well as organisations dedicated to the endorsement of teaching and training of scientists in pharmaceutical and veterinary sciences, are also key partners. Major objectives of the network include the following: strengthening academic research to promote the emergence of new concepts, principles and mechanisms of action to develop innovative new veterinary medicinal products, supporting the education and training of future healthcare professionals in veterinary practice, pharmacy and industrial research, including continuing professional development, and supporting Veterinary Universities. Further efforts of the Network will encourage the European Commission to initiate calls for research in the area of veterinary medicines, such as Horizon 2020. Once these calls are in place, the formation of strong consortia to apply for funding (IMI, EU-funding) is projected. The success of the Network depends on the engagement and expertise of cooperating specialists. It will benefit from the experience and means of other EUFEPS networks.
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| 9. |
- Karaoglu, E., et al.
(författare)
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Synthesis and characteristics of poly(3-pyrrol-1-ylpropanoic acid) (PPyAA)-Fe(3)O(4) nanocomposite
- 2011
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Ingår i: Journal of Alloys and Compounds. - : Elsevier BV. - 0925-8388 .- 1873-4669. ; 509:33, s. 8460-8468
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Tidskriftsartikel (refereegranskat)abstract
- Poly(3-pyrrol-1-ylpropanoic acid) (PPyAA)-Fe(3)O(4) nanocomposite was successfully synthesized by an in situ polymerization of 1-(2-carboxyethyl) pyrrole in the presence of synthesized Fe(3)O(4) nanoparticles. Evaluation of structural, morphological, electrical and magnetic properties of the nanocomposite was performed by XRD, FT-IR, TEM, TGA, magnetization and conductivity measurements, respectively. XRD analysis reveals the inorganic phase as Fe(3)O(4) and TGA shows about 90 wt% loading of Fe(3)O(4) in the nanocomposite. FT-IR analysis indicates a successful conjugation of Fe(3)O(4) particles with polypyrrole acetic acid. Magnetization measurements show that polypyrrole acetic acid coating decreases the saturation magnetization of Fe(3)O(4) significantly. This reduction has been explained by the pinning of the surface spins by the possible adsorption of non-magnetic ions during the polymerization process. The conductivity and dielectric permittivity measurements strongly depend on the thermally activated polarization mechanism and thermal transition of PPyAA in the nanocomposite structure. Large value of dielectric permittivity (epsilon') of the nanocomposite at lower frequency is attributed to the predominance of species like Fe(2+) ions and grain boundary defects (interfacial polarization).
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| 10. |
- Karaoglu, E., et al.
(författare)
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Synthesis and characterization of Piperidine-4-carboxylic acid functionalized Fe 3O 4 nanoparticles as a magnetic catalyst for Knoevenagel reaction
- 2012
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Ingår i: Materials research bulletin. - : Elsevier BV. - 0025-5408 .- 1873-4227. ; 47:9, s. 2480-2486
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Tidskriftsartikel (refereegranskat)abstract
- Piperidine-4-carboxylic acid (PPCA) functionalized Fe 3O 4 nanoparticles as a novel organic-inorganic hybrid heterogeneous catalyst was fabricated and characterized by XRD, FT-IR, TGA, TEM and VSM techniques. Composition was determined as Fe 3O 4, while particles were observed to have spherical morphology. Size estimations using X-ray line profile fitting (10 nm), TEM (11 nm) and magnetization fitting (9 nm) agree well, revealing nearly single crystalline character of Fe 3O 4 nanoparticles. Magnetization measurements reveal that PPCA functionalized Fe 3O 4 NPs have superparamagnetic features, namely immeasurable coercivity and absence of saturation. Small coercivity is established at low temperatures. The catalytic activity of Fe 3O 4-PPCA was probed through one-pot synthesis of nitro alkenes through Knoevenagel reaction in CH 2Cl 2 at room temperature. The heterogeneous catalyst showed very high conversion rates (97%) and could be recovered easily and reused many times without significant loss of its catalytic activity.
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