| 1. |
|
|
| 2. |
- Motiño, O, et al.
(författare)
-
ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis
- 2022
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:41, s. e2207344119-
-
Tidskriftsartikel (refereegranskat)abstract
- Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a monoclonal antibody neutralizing ACBP/DBI (α-DBI) protects the murine liver against ischemia/reperfusion damage, intoxication by acetaminophen and concanavalin A, and nonalcoholic steatohepatitis caused by methionine/choline-deficient diet as well as against liver fibrosis induced by bile duct ligation or carbon tetrachloride. α-DBI downregulated proinflammatory and profibrotic genes and upregulated antioxidant defenses and fatty acid oxidation in the liver. The hepatoprotective effects of α-DBI were mimicked by the induction of ACBP/DBI-specific autoantibodies, an inducibleAcbp/Dbiknockout or a constitutiveGabrg2F77Imutation that abolishes ACBP/DBI binding to the GABAAreceptor. Liver-protective α-DBI effects were lost when autophagy was pharmacologically blocked or genetically inhibited by knockout ofAtg4b. Of note, α-DBI also reduced myocardium infarction and lung fibrosis, supporting the contention that it mediates broad organ-protective effects against multiple insults.
|
|
| 3. |
- Motino, O, et al.
(författare)
-
ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis
- 2022
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:41, s. e2207344119-
-
Tidskriftsartikel (refereegranskat)abstract
- Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a monoclonal antibody neutralizing ACBP/DBI (α-DBI) protects the murine liver against ischemia/reperfusion damage, intoxication by acetaminophen and concanavalin A, and nonalcoholic steatohepatitis caused by methionine/choline-deficient diet as well as against liver fibrosis induced by bile duct ligation or carbon tetrachloride. α-DBI downregulated proinflammatory and profibrotic genes and upregulated antioxidant defenses and fatty acid oxidation in the liver. The hepatoprotective effects of α-DBI were mimicked by the induction of ACBP/DBI-specific autoantibodies, an inducibleAcbp/Dbiknockout or a constitutiveGabrg2F77Imutation that abolishes ACBP/DBI binding to the GABAAreceptor. Liver-protective α-DBI effects were lost when autophagy was pharmacologically blocked or genetically inhibited by knockout ofAtg4b. Of note, α-DBI also reduced myocardium infarction and lung fibrosis, supporting the contention that it mediates broad organ-protective effects against multiple insults.
|
|
| 4. |
- Bergqvist, Göran, et al.
(författare)
-
New electromagnetic conservation laws
- 2003
-
Ingår i: Classical and Quantum Gravity. - : IOP Publishing. - 0264-9381 .- 1361-6382. ; 20:13, s. 2663-2668
-
Tidskriftsartikel (refereegranskat)abstract
- The Chevreton superenergy tensor was introduced in 1964 as a counterpart, for electromagnetic fields, of the well-known Bel–Robinson tensor of the gravitational field. We here prove the unnoticed facts that, in the absence of electromagnetic currents, Chevreton's tensor (i) is completely symmetric, and (ii) has a trace-free divergence if the Einstein–Maxwell equations hold. It follows that the trace of the Chevreton tensor is a rank-2, symmetric, trace-free, conserved tensor, which is different from the energy–momentum tensor, and nonetheless can be constructed for any test Maxwell field or any Einstein–Maxwell spacetime.
|
|
| 5. |
- Edgar, Brian, 1945-, et al.
(författare)
-
The new potential for the Weyl tensor in n dimensions : wave equation and gauge
- 2008
-
Ingår i: Spanish Relativity Meeting 2007,2007. - Spain : EDR. ; , s. 245-248
-
Konferensbidrag (refereegranskat)abstract
- Although the Lanczos potential (a (2,1) form, L) for the Weyl tensor does not exist in dimensions greater than four, a new potential (a (2,3) form, P, which coincides with the double dual of L in four dimensions) has recently been shown to exist in all dimensions. In this talk we discuss the structure of its wave equation which is obtained from the Bianchi identities, and the related question of gauge.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
