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| 2. |
- Rauer, H., et al.
(författare)
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The PLATO 2.0 mission
- 2014
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 38:1-2, s. 249-330
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Tidskriftsartikel (refereegranskat)abstract
- PLATO 2.0 has recently been selected for ESA's M3 launch opportunity (2022/24). Providing accurate key planet parameters (radius, mass, density and age) in statistical numbers, it addresses fundamental questions such as: How do planetary systems form and evolve? Are there other systems with planets like ours, including potentially habitable planets? The PLATO 2.0 instrument consists of 34 small aperture telescopes (32 with 25 s readout cadence and 2 with 2.5 s cadence) providing a wide field-of-view (2232 deg(2)) and a large photometric magnitude range (4-16 mag). It focuses on bright (4-11 mag) stars in wide fields to detect and characterize planets down to Earth-size by photometric transits, whose masses can then be determined by ground-based radial-velocity follow-up measurements. Asteroseismology will be performed for these bright stars to obtain highly accurate stellar parameters, including masses and ages. The combination of bright targets and asteroseismology results in high accuracy for the bulk planet parameters: 2 %, 4-10 % and 10 % for planet radii, masses and ages, respectively. The planned baseline observing strategy includes two long pointings (2-3 years) to detect and bulk characterize planets reaching into the habitable zone (HZ) of solar-like stars and an additional step-and-stare phase to cover in total about 50 % of the sky. PLATO 2.0 will observe up to 1,000,000 stars and detect and characterize hundreds of small planets, and thousands of planets in the Neptune to gas giant regime out to the HZ. It will therefore provide the first large-scale catalogue of bulk characterized planets with accurate radii, masses, mean densities and ages. This catalogue will include terrestrial planets at intermediate orbital distances, where surface temperatures are moderate. Coverage of this parameter range with statistical numbers of bulk characterized planets is unique to PLATO 2.0. The PLATO 2.0 catalogue allows us to e. g.: - complete our knowledge of planet diversity for low-mass objects, - correlate the planet mean density-orbital distance distribution with predictions from planet formation theories,- constrain the influence of planet migration and scattering on the architecture of multiple systems, and - specify how planet and system parameters change with host star characteristics, such as type, metallicity and age. The catalogue will allow us to study planets and planetary systems at different evolutionary phases. It will further provide a census for small, low-mass planets. This will serve to identify objects which retained their primordial hydrogen atmosphere and in general the typical characteristics of planets in such a low-mass, low-density range. Planets detected by PLATO 2.0 will orbit bright stars and many of them will be targets for future atmosphere spectroscopy exploring their atmospheres. Furthermore, the mission has the potential to detect exomoons, planetary rings, binary and Trojan planets. The planetary science possible with PLATO 2.0 is complemented by its impact on stellar and galactic science via asteroseismology as well as light curves of all kinds of variable stars, together with observations of stellar clusters of different ages. This will allow us to improve stellar models and study stellar activity. A large number of well-known ages from red giant stars will probe the structure and evolution of our Galaxy. Asteroseismic ages of bright stars for different phases of stellar evolution allow calibrating stellar age-rotation relationships. Together with the results of ESA's Gaia mission, the results of PLATO 2.0 will provide a huge legacy to planetary, stellar and galactic science.
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| 3. |
- Menden, MP, et al.
(författare)
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Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2674-
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Tidskriftsartikel (refereegranskat)abstract
- The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.
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| 4. |
- Abdelakram, Hafid, et al.
(författare)
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Sensorized T-Shirt with Fully Integrated Textrodes and Measurement Leads with Textile-Friendly Methods
- 2024
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Ingår i: IFMBE Proceedings. - : Springer Science and Business Media Deutschland GmbH. - 9783031592157 ; , s. 227-234
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Konferensbidrag (refereegranskat)abstract
- Development in the field of smart wearable products for monitoring daily life health status is beginning to spread in society. Textile electronic methods are improving and facilitating the manufacturing of sensorized garments. This paper evaluates a newly developed t-shirt incorporating electronic sensing and interconnecting elements integrated into the T-shirt with textile-friendly techniques sensorized with a Movesense device for monitoring ECG and HR and activity. The measurement results obtained from the t-shirt are entirely in agreement with the measurements obtained with other textile garments and encourage us for a near future where wearable sensors are just textile garments sensorized seamlessly without suboptimal textile-electronic integrated elements.
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| 5. |
- Lu, Ke, et al.
(författare)
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Wearable cardiorespiratory monitoring system for unobtrusive free-living energy expenditure tracking
- 2019
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Ingår i: IFMBE Proceedings. - Singapore : Springer. ; , s. 433-437
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Konferensbidrag (refereegranskat)abstract
- In this work, we want to introduce combined heart rate and respiration monitoring for more accurate energy expenditure tracking on free-living subjects. We have developed a wearable cardiorespiratory monitoring system with unobtrusive heart rate measurement and ventilation estimation function for this purpose. The system is based on a garment with integrated textile electrodes for one-lead electrocardiogram and impedance pneumography measurements. A pilot experiment has been performed to prove the concept and to evaluate the characteristics of heart rate and ventilation estimated by our system in relation to energy expenditure. In the experiment, ventilation shows a better linearity in relation to the energy expenditure at the low intensity region than heart rate. Based on these characteristics, a model combining heart rate and ventilation for energy expenditure estimation is proposed which shows a significantly lower estimation error than the heart rate only model.
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| 10. |
- Cunico, F. J., et al.
(författare)
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Studying the performance of conductive polymer films as textile electrodes for electrical bioimpedance measurements
- 2013
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Ingår i: XV International Conference on Electrical Bio-Impedance (ICEBI) & XIV Conference on Electrical Impedance Tomography (EIT). - : IOP Publishing. ; , s. 012027-
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Konferensbidrag (refereegranskat)abstract
- With the goal of finding novel biocompatible materials suitable to replace silver in the manufacturing of textile electrodes for medical applications of electrical bioimpedance spectroscopy, three different polymeric materials have been investigated. Films have been prepared from different polymeric materials and custom bracelets have been confectioned with them. Tetrapolar total right side electrical bioimpedance spectroscopy (EBIS) measurements have been performed with polymer and with standard gel electrodes. The performance of the polymer films was compared against the performance of the gel electrodes. The results indicated that only the polypropylene 1380 could produce EBIS measurements but remarkably tainted with high frequency artefacts. The influence of the electrode mismatch, stray capacitances and large electrode polarization impedance are unclear and they need to be clarified with further studies. If sensorized garments could be made with such biocompatible polymeric materials the burden of considering textrodes class III devices could be avoided.
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