| 1. |
- Fridberg, Marie, et al.
(författare)
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Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma : higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN
- 2007
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Ingår i: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 48:11, s. 2221-2232
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Tidskriftsartikel (refereegranskat)abstract
- Patients diagnosed with diffuse large B-cell lymphoma (DLBCL) show varying responses to conventional therapy, and this might be contributed to the differentiation stage of the tumor B-cells. The aim of the current study was to evaluate a panel of kinases (ZAP70, PKC-β I and II and phosphorylated PKB/Akt) and phosphatases (PTEN, SHP1 and SHP2) known to be frequently deregulated in lymphoid malignancies. De novo DLBCL cases were divided into two subgroups, the germinal center (GC) group (14/28) and the non-germinal center (non-GC) or activated B-cell (ABC) group (14/28). ZAP70 and PKC-β II were expressed in a significantly higher percentage of tumor cells in the clinically more aggressive non-GC group compared with the prognostically favourable GC group. Also, the subcellular localization of PKC-β I and II differed in DLBCL cells, with the PKC-β I isoform being expressed in both the cytoplasm and nucleus, while PKC-β II was found exclusively in the cytoplasm. Loss of nuclear PTEN correlated with poor survival in cases from both subgroups. In addition, five cell lines of DLBCL origin were analyzed for protein expression and for mRNA levels of PTEN and SHP1. For the first time, we show that ZAP70 is expressed in a higher percentage of tumor cells in the aggressive non-GC subgroup of DLBCL and that PKC-β I and II are differently distributed in the two prognostic subgroups of de novo DLBCL.
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| 2. |
- Servin, Anna, et al.
(författare)
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Sex differences in 1-, 3-, 5-year-olds' toy-choice in a structured play-session
- 1999
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Ingår i: Scandinavian Journal of Psychology. ; 40, s. 43-48
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Tidskriftsartikel (refereegranskat)abstract
- This cross-sectional study investigated toy-choice in 38 one-year-old, 33 three-year-old, and 35 five-year-old children, who could choose between 10 different toys (four feminine, four masculine, and two neutral) in a structured play-session. The children
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| 3. |
- Servin, Anna
(författare)
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Sex differences in children's play behavior : A biological construction of gender?
- 1999
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present thesis addressed the question of what causes sex differences in children's play behavior.In Study I, it was found that mothers have rather sex-stereotyped expectations for how their 1- and 3-year-old children will behave at the age of five, as regards sex-typed activities. The parents' wishes, however, were less stereotyped, even if they differed significantly depending on the sex of the child. In Study II, where girls and boys at 1, 3, and 5 years of age were studied, and Study III, where girls and boys at 6, 9, 12 months of age were studied, in two different structured play situations, sex differences in toy play were observable already at the age of 12 months. In Study IV, the play behavior of girls affected by congenital adrenal hyperplasia (CAB) was studied. Their play was compared with that of non-affected girls. A clear dose-response relationship was found between prenatal androgen levels (genotype) and toy preferences. Parents' participation did not affect the children's play; A questionnaire showed that although parents of girls with CAH expected and described more masculine interests, their wishes were not different from those of parents of non-affected girls.The results are discussed in terms of how biology can affect such specific behaviors as toy play. It is suggested that evolution has provided the biological base for the observed sex differences, and probably for general sex differences between girls and boys, and women and men.
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| 4. |
- Thoeni, Klaus, et al.
(författare)
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Designing waste rock barriers by advanced numerical modelling
- 2019
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Ingår i: Journal of Rock Mechanics and Geotechnical Engineering. - : Elsevier. - 1674-7755. ; 11:3, s. 659-675
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Tidskriftsartikel (refereegranskat)abstract
- Design of waste rock barriers forming safety berms for haul trucks requires knowledge of complex interactions which cannot readily be tested by physical means. An advanced numerical model based on non-smooth multi-domain mechanics is presented together with model calibration using limited full-scaleexperimental data. Waste rock is represented by spherical particles with rolling resistance, and an ultra-class haul truck is represented by a rigid multibody system interconnected with mechanical joints. The model components are first calibrated and then the calibrated model is used for simulating various collision scenarios with different approach conditions and safety berm geometries. Numerical predictions indicate that the width of the berm is most critical for efficiently stopping a runaway truck. The model can also predict if a certain berm geometry is capable of stopping a runaway truck. Results are summarised in a series of diagrams intended for use as design guidelines by practitioners and engineers.
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| 5. |
- Thoeni, Klaus, et al.
(författare)
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Using non-smooth multi-domain dynamics to improve the safety on haul roads in surface mining
- 2017
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Ingår i: The V International Conference on Particle-Based Methods. Fundamentals and Applications. - Barcelona, Spain : International Center for Numerical Methods in Engineering (CIMNE). - 9788494690976 ; , s. 600-611
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Konferensbidrag (refereegranskat)abstract
- The paper presents a preliminary numerical study aimed to improve the safety on haul roads in surface mining. The interaction and collision between granular berms and ultra-class haul trucks are investigated by using non-smooth multi-domain dynamics. The haul truck is modelled as a rigid multibody system and the granular berm as a distribution of rigid particles using the discrete element method. A non-smooth dynamics approach is applied to enable stable and time-efficient simulation of the full system with strong coupling. The numerical model is first calibrated using full-scale data from experimental tests and then applied to investigate the collision between the haul truck and granular berms of different geometry under various approach conditions.
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