| 1. |
- Sliz, E., et al.
(författare)
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Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
- 2023
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.
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| 2. |
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| 3. |
- Kurki, MI, et al.
(författare)
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FinnGen provides genetic insights from a well-phenotyped isolated population
- 2023
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 613:7944, s. 508-
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Tidskriftsartikel (refereegranskat)abstract
- Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These variants survived the founding bottleneck rather than being distributed over a large number of ultrarare variants. Although this effect is well established in Mendelian genetics, its value in common disease genetics is less explored1,2. FinnGen aims to study the genome and national health register data of 500,000 Finnish individuals. Given the relatively high median age of participants (63 years) and the substantial fraction of hospital-based recruitment, FinnGen is enriched for disease end points. Here we analyse data from 224,737 participants from FinnGen and study 15 diseases that have previously been investigated in large genome-wide association studies (GWASs). We also include meta-analyses of biobank data from Estonia and the United Kingdom. We identified 30 new associations, primarily low-frequency variants, enriched in the Finnish population. A GWAS of 1,932 diseases also identified 2,733 genome-wide significant associations (893 phenome-wide significant (PWS), P < 2.6 × 10–11) at 2,496 (771 PWS) independent loci with 807 (247 PWS) end points. Among these, fine-mapping implicated 148 (73 PWS) coding variants associated with 83 (42 PWS) end points. Moreover, 91 (47 PWS) had an allele frequency of <5% in non-Finnish European individuals, of which 62 (32 PWS) were enriched by more than twofold in Finland. These findings demonstrate the power of bottlenecked populations to find entry points into the biology of common diseases through low-frequency, high impact variants.
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| 4. |
- Hakkarainen, T., et al.
(författare)
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Near-field imaging of interacting nano objects with metal and metamaterial superlenses
- 2012
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Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 14, s. 043019-
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Tidskriftsartikel (refereegranskat)abstract
- Employing rigorous electromagnetic theory we investigate optical the near-field imaging of two interacting dipole-like objects with metal and slightly lossy metamaterial nanoslab superlenses. Our analysis indicates that the dipole emission is suppressed by near-field interactions when the objects are close to the lens or each other. This strongly influences the image quality, in particular with objects of small size and high polarizability. The interference from two nearby objects also affects the resolution and subwavelength definition can only be obtained for objects with dipole moments predominantly orthogonal to the slab. Such an optimal imaging condition is achieved with excitation by total internal reflection. With simulations we show that in these circumstances, subwavelength resolutions of about lambda/5 for silver superlens and lambda/10 for metamaterial slab are reached.
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| 5. |
- Hakkarainen, T., et al.
(författare)
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Near-field imaging of point dipole with silver superlens
- 2010
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Ingår i: Applied physics. B, Lasers and optics (Print). - : Springer Science and Business Media LLC. - 0946-2171 .- 1432-0649. ; 101:4, s. 731-734
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Tidskriftsartikel (refereegranskat)abstract
- Making use of exact and quasistatic expressions for the field in near-field imaging of a point dipole by a thin silver slab, we calculate the point-spread function and the associated image resolution. We show that the resolution, which depends on the silver slab thickness and the dipole orientation, generally is better than the conventional diffraction limit and can be as high as lambda/8. The results substantially agree with recent theoretical and experimental studies on 2D objects.
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| 6. |
- Hassinen, T., et al.
(författare)
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Hanbury Brown-Twiss effect with electromagnetic waves
- 2011
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Ingår i: Optics Express. - 1094-4087. ; 19:16, s. 15188-15195
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Tidskriftsartikel (refereegranskat)abstract
- The classic Hanbury Brown-Twiss experiment is analyzed in the space-frequency domain by taking into account the vectorial nature of the radiation. We show that as in scalar theory, the degree of electromagnetic coherence fully characterizes the fluctuations of the photoelectron currents when a random vector field with Gaussian statistics is incident onto the detectors. Interpretation of this result in terms of the modulations of optical intensity and polarization state in two-beam interference is discussed. We demonstrate that the degree of cross-polarization may generally diverge. We also evaluate the effects of the state of polarization on the correlations of intensity fluctuations in various circumstances.
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| 7. |
- Jouttenus, T., et al.
(författare)
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Connection between electric and magnetic coherence in free electromagnetic fields
- 2005
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Ingår i: Physical Review E. - 1539-3755. ; 72:4
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Tidskriftsartikel (refereegranskat)abstract
- We introduce quantitative measures for the description of the electric and magnetic coherence in a stationary, random electromagnetic field at two points, in a volume, and in the Fourier space. These quantities are applied to free electromagnetic fields, and several theorems regarding the relationship between the two types of coherences in such fields are established. Fields which are statistically homogeneous, and those which, in addition, are statistically isotropic are considered separately. Furthermore, the connection between the electric and magnetic coherence is exemplified for some specific statistically homogeneous fields.
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| 8. |
- Saastamoinen, T., et al.
(författare)
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Electromagnetic coherence theory of laser resonator modes
- 2005
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Ingår i: Journal of the Optical Society of America a-Optics Image Science and Vision. - 1084-7529. ; 22:1, s. 103-108
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Tidskriftsartikel (refereegranskat)abstract
- A theory of open laser resonators is formulated within the framework of the electromagnetic coherence theory. It is shown that if only one Fox-Li mode contributes to the field at a given frequency. then the field at that frequency is necessarily completely coherent in view of the space- frequency, counterpart of the recently introduced degree of coherence of electromagnetic fields [Opt. Express 11, 1137 (2003)]. It is also shown that the relation between the number of Fox-Li modes and the new degree of coherence is analogous to the relation established in the scalar theory of laser resonator modes. Difficulties that arise with the formerly introduced visibility-based definition of the electromagnetic degree of coherence are briefly discussed.
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| 9. |
- Shirai, T., et al.
(författare)
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Classical ghost diffraction enabling aberration-corrected imaging
- 2012
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Ingår i: Frontiers in Optics, FIO 2012. - 9781557529565
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Konferensbidrag (refereegranskat)abstract
- We describe a method for image transmission through an aberrating medium by means of a modified configuration for conventional ghost diffraction with classical incoherent beams and show theoretically that the method enables aberration-corrected imaging.
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| 10. |
- Alonso, M. A., et al.
(författare)
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Optimal pulses for arbitrary dispersive media
- 2011
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Ingår i: Journal of the European Optical Society-Rapid Publications. - : European Optical Society. - 1990-2573. ; 6, s. 11035-
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Tidskriftsartikel (refereegranskat)abstract
- A variational procedure is given for finding the pulses for which the initial temporal rms width and the rate of increase of this width are jointly minimized for propagation in non-absorbing media with arbitrary dispersive properties. We show that, while in linearly dispersive media the optimal pulses are Gaussian, in other situations such as a hollow metallic waveguide or for purely cubic dispersion departures from Gaussian behavior become evident. An interpretation of the results in terms of suitable phase-space representations is also given.
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