| 1. |
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| 2. |
- Bellenguez, C, et al.
(författare)
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New insights into the genetic etiology of Alzheimer's disease and related dementias
- 2022
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:4, s. 412-436
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Tidskriftsartikel (refereegranskat)abstract
- Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
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| 3. |
- Wightman, D. P., et al.
(författare)
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A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
- 2021
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:9, s. 1276-1282
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Tidskriftsartikel (refereegranskat)abstract
- Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer’s disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer’s disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer’s disease to identify further genetic variants that contribute to Alzheimer’s pathology.
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| 4. |
- Ovsyannikov, Gennady, 1948, et al.
(författare)
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Proximity effect and electron transport in oxide hybrid heterostructures with superconducting/magnetic interfaces
- 2011
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Ingår i: Superconductor Science and Technology. - : IOP Publishing. - 0953-2048 .- 1361-6668. ; 24:5, s. Art. no. 055012-
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Tidskriftsartikel (refereegranskat)abstract
- We report on electron transport in oxide heterostructures with superconducting/magnetic (S/M) thin film interfaces. The investigated hybrid mesa-heterostructures consist of a cuprate superconductor, a nonsuperconducting cuprate (antiferromagnetic) or manganite (ferromagnetic) interlayer with thickness d(M) = 5-50 nm and a conventional superconductor (Nb). The superconducting critical current (I-C) with a critical current density j(c) = 10(3) A cm(-2) (for d(M) = 10 nm) and a characteristic voltage ICRN = 100-200 mu V (RN is normal resistance) are observed at liquid helium temperature for a CaXSr1-XCuO2 antiferromagnetic cuprate interlayer with a thickness of d(M) = 10-50 nm. The superconducting current-phase relation of heterostructures deviates from the regular sine type, demonstrating a second harmonic component. These hybrid heterostructures with S/M interfaces show unusually high sensitivity to external magnetic fields. When substituting the cuprate interlayer by a manganite film, no critical current was observed although the manganite interlayer was made several times thinner (down to d(M)
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| 5. |
- Constantinian, K. Y., et al.
(författare)
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Electron transport and microwave dynamics of hybrid Nb/Au/CaSrCuO/YBaCuO planar Josephson junctions
- 2009
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 234:4, s. Art. no. 042004-
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Konferensbidrag (refereegranskat)abstract
- We report on measurements of dc electron transport and microwave dynamics of thin film hybrid Josephson junctions with an oxide antiferromagnetic interlayer. The base superconducting electrode YBaCuO and the antiferromagnetic (AF) interlayer CaSrCuO (with thickness d 20 - 70 nm) were grown by laser ablation on NdGaO3 substrates. I-V curves were well fitted to RSJ model and had no excess current, ICRN products were of order 0.2 mV at T=4.2 K. We did not observe any noticeable reduction of I CRN with increasing d. Such "tunnellike" behaviour also resulted in appearance of singularities on I-V curve when magnetic field was applied. Oscillating with microwave power integer and half-integer Shapiro steps were registered along with sub-harmonic detector response. Moreover, for some of junctions a "devil" staircase structure was observed on I-V curves and giant noise-like signals were measured in 1-2 GHz band at the certain levels of microwave power. Observed features, noise performance and the impact of the second harmonic in current-phase relation on junction dynamics are discussed taking into account data for structures without AF interlayer.
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| 6. |
- Zaǐtsev, A. V., et al.
(författare)
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Superconducting current in hybrid structures with an antiferromagnetic interlayer
- 2010
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Ingår i: Journal of Experimental and Theoretical Physics. - 1090-6509 .- 1063-7761. ; 110:2, s. 336-344
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Tidskriftsartikel (refereegranskat)abstract
- It is shown experimentally that the superconducting current density in Nb/Au/Ca1 - x Sr (x) CuO2/YBa2Cu3O7 - delta hybrid superconducting heterostructures with a Ca1 - x Sr (x) CuO2 anti-ferromagnetic (AF) cuprate interlayer is anomalously high for interlayer thicknesses d (M) = 10-50 nm and the characteristic damping length for superconducting correlations is on the order of 10 nm. The experimental results are explained on the basis of theoretical analysis of a junction of two superconductors (S' and S) connected by a magnetic multilayer with the AF ordering of magnetization in the layers. It is shown that with such a magnetization ordering, anomalous proximity effect determined by the singlet component of the condensate wavefunction may take place. As a result, the critical currents in S'/I/AF/S and S'/I/N/S structures (I denotes an insulator, and N, the normal metal) may coincide in order of magnitude even when the thickness of the AF interlayer considerably exceeds the decay length of the condensate wavefunction in ferromagnetic layers.
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| 7. |
- Demidov, V. V., et al.
(författare)
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Magnetic anisotropy in strained manganite films and bicrystal junctions
- 2013
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 113:16
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Tidskriftsartikel (refereegranskat)abstract
- Transport and magnetic properties of La0.67Sr0.33MnO3 (LSMO) manganite thin films and bicrystal junctions were investigated. Epitaxial manganite films were grown on SrTiO3, LaAlO3, NdGaO3 (NGO), and (LaAlO3)(0.3) + (Sr2AlTaO6)(0.7) substrates, and their magnetic anisotropy were determined by two independent techniques of magnetic resonance spectroscopy. It was demonstrated that by using these techniques, a small (0.3%) anisotropy of crystal structure at the (110) surface plane of the orthorhombic NGO substrate leads to uniaxial magnetic anisotropy of the films in the plane of the substrate at least at the room temperature. It was found that on vicinal NGO substrates, the value of magnetic anisotropy strength can be varied in the range 100-200 Oe at T = 295 K by changing the substrate vicinal angle from 0 degrees to 25 degrees. Measurement of the magnetic anisotropy of manganite bicrystal junction demonstrated the presence of two ferromagnetic spin subsystems for both types of bicrystal boundaries with tilting of basal plane of manganite tilted bicrystal (TB-junction) and with rotation of crystallographic axes (RB-junction) used for comparison. The magnetoresistance of TB-junctions increases with decreasing temperature and the misorientation angle. Variation of bicrystal misorientation angle does not lead to change of misorientation of easy magnetic axes in the film parts forming TB-junction. Analysis of the voltage dependencies of bicrystal junction conductivity show that the low value of the magnetoresistance for the LSMO bicrystal junctions can be caused by two scattering mechanisms. The first one is the spin-flip of spin-polarized carriers due to the strong electron-electron interactions in a disordered layer at the bicrystal boundary at low temperatures and the second one is spin-flip by antiferromagnetic magnons at high temperatures.
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| 8. |
- Kislinskiǐ, Yu V., et al.
(författare)
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Copper oxide superconducting/antiferromagnetic interface
- 2015
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Ingår i: Solid State Phenomena. - 1662-9779 .- 1012-0394. - 9783038354826 ; 233-234, s. 733-736
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Konferensbidrag (refereegranskat)abstract
- Superconducting Nb/Au/Ca1-xSrxCuO2/YBa2Cu3O7 mesa-heterostructures were investigated. Dependencies of electrical parameters versus inverse capacitance were measured. A band diagram which takes into account an accumulation of holes inCa1-xSrxCuO2 interlayer and band bending due to difference of work functions was proposed. The dependencies of electrical parameters were analyzed by examining the quasipartical and superconducting currents.
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| 9. |
- Petrzhik, A. M., et al.
(författare)
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Electron transport in hybrid superconductor heterostructures with manganite interlayers
- 2011
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Ingår i: Journal of Experimental and Theoretical Physics. - : Pleiades Publishing Ltd. - 1090-6509 .- 1063-7761. ; 112:6, s. 1042-1050
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Tidskriftsartikel (refereegranskat)abstract
- Hybrid herostructures comprising an YBa(2)Cu(3)O (x) (YBCO) high-temperature superconductor (HTS) layer and Nb/Au low-temperature superconductor (LTS) bilayer (with critical HTS and LTS temperatures T (c) and T'(c), respectively), separated by a thin (d (M) = 5-20 nm) interlayer of LaMnO(3), La(0.7)Ca(0.3)MnO(3), or La(0.7)Sr(0.3)MnO(3) manganite have been studied. The electric resistance and magnetic properties of individual (evaporated directly onto the substrate) manganite films and related hybrid herostructures have been measured. Based on quasi-classical equations, analytical expressions for the conductivity of herostructures at T a parts per thousand currency sign T'(c) are obtained in the case of a low-transparency superconductor/manganite interface. It is established that the conductivity of heterostructures is determined by the proximity effect (related to the penetration of a condensate wavefunction from the Nb/Au bilayer to manganite) and depends strongly on interface transparency. At low temperatures (T a parts per thousand(a) T (c)'), the conductivity peaks are found at voltages determined by the exchange field of the manganite interlayer. At T (c)'
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| 10. |
- Khaydukov, Yu. N., et al.
(författare)
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Evidence for spin-triplet superconducting correlations in metal-oxide heterostructures with noncollinear magnetization
- 2014
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Ingår i: Physical Review B - Condensed Matter and Materials Physics. - 2469-9950 .- 2469-9969. ; 90:3, s. Article no. 035130 -
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Tidskriftsartikel (refereegranskat)abstract
- Heterostructures composed of ferromagnetic La0.7Sr0.3MnO3, ferromagnetic SrRuO3, and superconducting YBa2Cu3O6+x were studied experimentally. Structures of composition Au/La0.7Sr0.3MnO3/SrRuO3/YBa2Cu3O6+x were prepared by pulsed laser deposition, and their high quality was confirmed by x-ray diffraction and reflectometry. Anoncollinear magnetic state of the heterostructureswas revealed by means of superconducting quantum interference device magnetometry and polarized neutron reflectometry. We have further observed superconducting currents in mesa structures fabricated by deposition of a second superconducting Nb layer on top of the heterostructure, followed by patterning with photolithography and ion-beam etching. Josephson effects observed in these mesa structures can be explained by the penetration of a triplet component of the superconducting order parameter into the magnetic layers.
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