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| 2. |
- Jin, Ying-Hui, et al.
(författare)
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Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19 : An evidence-based clinical practice guideline (updated version)
- 2020
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Ingår i: Military Medical Research. - : Springer Science and Business Media LLC. - 2054-9369. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued "A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)"; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. We formed a working group of clinical experts and methodologists. The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas: chemoprophylaxis, diagnosis, treatments, and discharge management. We searched the literature for direct evidence on the management of COVID-19, and assessed its certainty generated recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Recommendations were either strong or weak, or in the form of ungraded consensus-based statement. Finally, we issued 34 statements. Among them, 6 were strong recommendations for, 14 were weak recommendations for, 3 were weak recommendations against and 11 were ungraded consensus-based statement. They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). We also created two figures of these recommendations for the implementation purpose. We hope these recommendations can help support healthcare workers caring for COVID-19 patients.
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| 3. |
- Gao, Zhaoju, et al.
(författare)
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Short-chain ligand achieves ultra-stable CsPbX3 perovskite quantum dots for white light-emitting diodes
- 2024
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Ingår i: Applied Physics Letters. - : American Institute of Physics (AIP). - 0003-6951 .- 1077-3118. ; 124:4
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Tidskriftsartikel (refereegranskat)abstract
- All-inorganic perovskite quantum dots (PeQDs) have aroused great research interest in white light-emitting diodes (WLED) due to their excellent optoelectronic properties, but the poor stability, caused by dynamically binding long-chain capping ligands, hinders their future practical applications. To address this issue, here, we exploit short-chain butyric acid (BA) to replace long-chain oleic acid (OA) as capping ligand of CsPbX3 PeQDs by a hot-injection method. The addition of BA not only makes the morphology of CsPbBr3 PeQDs uniform and improves the crystallinity but also effectively suppresses nonradiative recombination, achieving a near unit photoluminescence quantum yield of 96%. The BA capped CsPbBr3 PeQDs exhibit high stability up to 180 d stored in ambient environment and also significantly improved resistance against polar solvent, ultra-violet lamp irradiation, and heat, which is rationalized by the strong binding capacity and shortened distance of BA to the PeQDs through ab initio calculations. Furthermore, by combining green-emission CsPbBr3 and red-emission CsPbBr0.8I2.2 PeQDs with blue GaN chip, we achieved WLEDs with excellent luminous properties, showing their great potential in practical application of wide-color-gamut display and lighting.
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| 4. |
- Ge, Xiaodong, et al.
(författare)
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Amelioration of type 2 diabetes by the novel 6, 8-guanidyl luteolin quinone-chromium coordination via biochemical mechanisms and gut microbiota interaction
- 2023
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Ingår i: JOURNAL OF ADVANCED RESEARCH. - : Elsevier. - 2090-1232 .- 2090-1224. ; 46, s. 173-188
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Luteolin is a plant-derived flavonoid that exhibits a broad range of pharmacological activ-ities. Studies on luteolin have mainly focused on its use for hyperlipidaemia prevention, whereas the capacity of the flavonoid to hinder hyperglycaemia development remains underexplored.Objectives: To probe the anti-hyperglycemic mechanism of 6,8-guanidyl luteolin quinone-chromium coordination (GLQ.Cr), and to assess its regulatory effect on intestinal microbiota in type 2 diabetes mel-litus (T2DM) mice.Methods: High-sucrose/high-fat diet-induced and intraperitoneal injection of streptozotocin was used to develop a T2DM model. Glycometabolism related indicators, histopathology, and gut microbiota compo-sition in caecum samples were evaluated, and RNA sequencing (RNA-seq) of liver samples was con-ducted. Faecal microbiota transplantation (FMT) was further used to verify the anti-hyperglycemic activity of intestinal microbiota.Results: The administration of GLQ.Cr alleviated hyperglycaemia symptoms by improving liver and pan-creatic functions and modulating gut microbe communities (Lactobacillus, Alistipes, Parabacteroides, Lachnoclostridium, and Desulfovibrio). RNA-seq analysis showed that GLQ.Cr mainly affected the peroxi-some proliferative activated receptor (PPAR) signalling pathway in order to regulate abnormal glucose metabolism. FMT significantly modulated the abundance of Lactobacillus, Alloprevotella, Alistipes, Bacteroides, Ruminiclostridium, Brevundimonas and Pseudomonas in the caecum to balance blood glucose levels and counteract T2DM mice inflammation.Conclusion: GLQ.Cr improved the abnormal glucose metabolism in T2DM mice by regulating the PPAR signalling pathway and modulating intestinal microbial composition. FMT can improve the intestinal microecology of the recipient and in turn ameliorate the symptoms of T2DM-induced hyperglycaemia.
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| 5. |
- Li, Youbing, et al.
(författare)
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Electrochemical Lithium Storage Performance of Molten Salt Derived V2SnC MAX Phase
- 2021
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Ingår i: Nano-Micro Letters. - : Springer. - 2311-6706 .- 2150-5551. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- MAX phases are gaining attention as precursors of two-dimensional MXenes that are intensively pursued in applications for electrochemical energy storage. Here, we report the preparation of V2SnC MAX phase by the molten salt method. V2SnC is investigated as a lithium storage anode, showing a high gravimetric capacity of 490 mAh g(-1) and volumetric capacity of 570 mAh cm(-3) as well as superior rate performance of 95 mAh g(-1) (110 mAh cm(-3)) at 50 C, surpassing the ever-reported performance of MAX phase anodes. Supported by operando X-ray diffraction and density functional theory, a charge storage mechanism with dual redox reaction is proposed with a Sn-Li (de)alloying reaction that occurs at the edge sites of V2SnC particles where Sn atoms are exposed to the electrolyte followed by a redox reaction that occurs at V2C layers with Li. This study offers promise of using MAX phases with M-site and A-site elements that are redox active as high-rate lithium storage materials.
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| 6. |
- Liu, Yong-feng, et al.
(författare)
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Sulfur quantum dot as a fluorescent nanoprobe for Fe3+ ions : Uncovering of detection mechanism, high sensitivity, and large detection range
- 2023
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Ingår i: Journal of Luminescence. - : Elsevier. - 0022-2313 .- 1872-7883. ; 257
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Tidskriftsartikel (refereegranskat)abstract
- Sulfur quantum dots (SQDs), as a novel metal-free fluorescent material, are getting increasingly tremendous attention in metal ion detection, especially for Fe3+, due to the merits of antimicrobial potential, low toxicity, and exciting optoelectronic properties. However, sensing mechanism of SQD based fluorescent probe for Fe3+ is not clear yet, and high sensitivity and large detection range remain a challenge. Here, we report the synthesis of hydrophilic SQDs as a fluorescent nanoprobe for Fe3+ via a fluorescent turn-off mode. We systematically studied the quenching mechanism by ultraviolet–visible absorption spectra, steady-state and time-resolved photoluminescent spectra, and temperature-dependent quenching constants. Results unclearly evidenced the quenching behavior to both inner filter effect and static quenching. Furthermore, the nanoprobe presents a large detection range from 2.5 to 700 μM and a limit of detection low to 53.6 nM, both of which are the record performance to our knowledge. At last, it shows high selectivity toward Fe3+ and presents no ionic strength effect in the range of investigation, which enables surprising results for Fe3+ detection in deionized water with interference ion and real water samples.
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| 7. |
- Peltonen, Laura-Maria, et al.
(författare)
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Nursing Informatics Research Trends : Findings from an International Survey.
- 2021
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Ingår i: Studies in Health Technology and Informatics. - 0926-9630 .- 1879-8365. ; 284, s. 344-349
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Tidskriftsartikel (refereegranskat)abstract
- This follow-up survey on trends in Nursing Informatics (NI) was conducted by the International Medical Informatics Association (IMIA) Student and Emerging Professionals (SEP) group as a cross-sectional study in 2019. There were 455 responses from 24 countries. Based on the findings NI research is evolving rapidly. Current ten most common trends include: clinical quality measures, clinical decision support, big data, artificial intelligence, care coordination, education and competencies, patient safety, mobile health, description of nursing practices and evaluation of patient outcomes. The findings help support the efforts to efficiently use resources in the promotion of health care activities, to support the development of informatics education and to grow NI as a profession.
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| 8. |
- Shao, Jie, et al.
(författare)
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Wavelength-modulated tunable diode-laser absorption spectrometry for real-time monitoring of microbial growth
- 2016
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Ingår i: Applied Optics. - 1559-128X .- 2155-3165. ; 55:9, s. 2339-2345
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Tidskriftsartikel (refereegranskat)abstract
- It is important to monitor and assess the growth of micro-organisms under various conditions. Yet, thus far there has been no technique to do this with the required speed and accuracy. This work demonstrates swift and accurate assessment of the concentration of carbon dioxide that is produced by use of a wavelength-modulated tunable diode-laser based absorption spectroscopy (WM-TDLAS). It is shown by experiments on two types of bacteria, Staphylococcus aureus and Candida albicans, that the technique can produce high signal-to-noise-ratio data from bacteria grown in confined spaces and exposed to limited amounts of nutrients that can be used for extraction of growth parameters by fitting of the Gompertz model. By applying the technique to S. aureus bacteria at various temperatures (in the 25 degrees C to 42 degrees C range), it is specifically shown that both the maximum growth rate and the so-called lag time have a strong temperature dependence (under the specific conditions with a maximum of the former at 37 degrees C) that matches conventional models well for bacterial growth. Hence, it is demonstrated that WM-TDLAS monitoring CO2 is a user-friendly, non-intrusive, and label-free technique that swiftly, and with high signal-to-noise-ratio, can be used for rapid (on the Hz scale) and accurate assessment of bacterial growth.
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| 9. |
- Shao, Xuan, et al.
(författare)
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Revisit Surround-view Camera System Calibration
- 2019
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Ingår i: 2019 IEEE International Conference on Multimedia and Expo (ICME). - Shanghai : Institute of Electrical and Electronics Engineers (IEEE). - 9781538695524 - 9781538695531 ; , s. 1486-1491
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Konferensbidrag (refereegranskat)abstract
- The surround-view system is an essential component of an advanced driver assistance system especially when the vehicle runs in tight parking space or on a narrow road. To ensure successful maneuvering, a panoramic bird's-eye image with no blind spots is necessarily called for. Hence, a typical surround-view system consists of several cameras mounted around the vehicle capturing images from a top-down viewpoint, and an accurate extrinsic calibration for such system is prerequisite for providing a seamless surround-view image. To achieve this goal, this paper presents a novel extrinsic calibration pipeline which is both easy-to-use and reliable to operate on multiple cameras. Instead of taking the vehicle to a fixed position in a specific calibration site, a single chessboard is the only demand. We adopt a novel refinement procedure that jointly optimizes camera poses in a closed-loop manner. The effectiveness and efficiency of the proposed pipeline to calibrate a surround-view camera system has been corroborated by experiments.
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| 10. |
- Sheng, Rongrong, et al.
(författare)
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Does hot weather affect work-related injury? A case-crossover study in Guangzhou, China
- 2018
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Ingår i: International Journal of Hygiene and Environmental Health. - : Elsevier BV. - 1438-4639. ; 221:3, s. 423-428
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Tidskriftsartikel (refereegranskat)abstract
- Background: Despite increasing concerns about the health effects of climate change, the extent to which workers are affected by hot weather is not well documented. This study aims to investigate the association between high temperatures and work-related injuries using data from a large subtropical city in China. Methods: We used workers’ compensation claims to identify work-related injuries in Guangzhou, China during 2011–2012. To feature the heat effect, the study period was restricted to the warm seasons in Guangzhou (1 May-31 October). We conducted a time-stratified case-crossover study to examine the association between ambient outdoor temperatures, including daily maximum and minimum temperatures, and cases of work-related injury. The relationships were assessed using conditional Poisson regression models. Results: Overall, a total of 5418 workers’ compensation claims were included over the study period. Both maximum and minimum temperatures were significantly associated with work-related injuries, but associations varied by subgroup. One °C increase in maximum temperature was associated with a 1.4% (RR = 1.014, 95%CIs 1.012–1.017) increase in daily injury claims. Significant associations were seen for male and middle-aged workers, workers in small and medium-sized enterprises, and those working in manufacturing sector. And 1 °C increase in minimum temperature was associated with 1.7% (RR = 1.017, 95%CIs 1.012–1.021) increase in daily injury claims. Significant associations were observed for female and middle-aged workers, workers in large-sized enterprises, and those working in transport and construction sectors. Conclusions: We found a higher risk of work-related injuries due to hot weather in Guangzhou, China. This study provides important epidemiological evidence for policy-makers and industry that may assist in the formulation of occupational safety and climate adaptation strategies.
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