| 1. |
- Tuli, Hardeep Singh, et al.
(författare)
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Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer : A signature step hinting towards clinical perfection
- 2023
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Ingår i: Translational Oncology. - : Elsevier BV. - 1936-5233. ; 27
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Tidskriftsartikel (refereegranskat)abstract
- Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this dreaded disease. Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant toxicity towards the normal cells. Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). They play pivotal roles in regulation of various biological and pathological processes, including various cancers. In the present review, the structure, chemistry and miR targeting efficacy of quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin against several cancer types are comprehensively discussed. miRs are considered as next-generation medicine of recent times, and their targeting by naturally occurring flavonoids in cancer cells could be deemed as a signature step. We anticipate that our compilations related to miRNA-mediated regulation of cancer cells by flavonoids might catapult the clinical investigations and affirmation in the future.
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| 2. |
- Botsinis, Panagiotis, et al.
(författare)
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New Access and Flexible Topologies in 6G: Architectural Implications
- 2024
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Ingår i: 2024 Joint European Conference on Networks and Communications and 6G Summit (EuCNC/6G Summit 2024). - : IEEE. ; , s. 682-687
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Konferensbidrag (refereegranskat)abstract
- 6G goals, such as improved coverage, flexibility to different network scenarios, increased throughput, higher robustness and reliability could be advanced with the use of new access and flexible topologies. In this contribution, three enablers of new access and flexible topologies, which contribute to the aforementioned goals, are presented, namely network of networks, multi-connectivity and E2E context awareness management. Relevant studies of each enabler that impact the system architecture are described, along with the corresponding overviews of potential solutions. In addition, each enabler has been mapped to the 6G E2E system blueprint proposed by the Hexa-X-II project and its impact to the system, as well as the relevant stakeholders have been identified.
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| 3. |
- Gupta, Rajeev Kumar, et al.
(författare)
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Influence of 11 years of crop residue management on rice productivity under varied nitrogen levels in the rice-wheat cropping system
- 2023
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Ingår i: Plant, Soil and Environment (Praha). - : Czech Academy of Agricultural Sciences. - 1214-1178 .- 1805-9368. ; 69:7, s. 333-343
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Tidskriftsartikel (refereegranskat)abstract
- The present study compares the six crop residue management techniques in main plots (since 2008) and three split nitrogen (N) levels, i.e., 75, 100 and 125 kg N/ha in subplots for rice crops for two years, i.e., 2019 and 2020, in sandy loam soil under field conditions. This experiment evaluated the long-term effect on rice productivity, soil organic carbon content and nutrient requirement in rice-wheat cropping system. The results revealed that different crop residue management practices and N levels significantly influenced rice growth, yield and yield attributes and improved nutrient uptake by grain and straw. Maximum grain yields of 20.8% and 17.8% higher over the conventional (no straw) treatment during 2019 and 2020, respectively, were recorded where the rice and wheat residue was re-tained or incorporated. The rice grain yield without residue responded significantly up to 125 kg N/ha. Whereas, with rice and wheat residue, rice grain yield did not respond to the application of N beyond 75 kg N/ha during both years.
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| 4. |
- Gupta, Rajeev Kumar, et al.
(författare)
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Interactive effects of long-term management of crop residue and phosphorus fertilization on wheat productivity and soil health in the rice–wheat
- 2024
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- In the context of degradation of soil health, environmental pollution, and yield stagnation in the rice–wheat system in the Indo-Gangetic Plains of South Asia, an experiment was established in split plot design to assess the long-term effect of crop residue management on productivity and phosphorus requirement of wheat in rice–wheat system. The experiment comprised of six crop residue management practices as the main treatment factor with three levels (0, 30 and 60 kg P2O5 ha–1) of phosphorus fertilizer as sub-treatments. Significant improvement in soil aggregation, bulk density, and infiltration rate was observed under residue management (retention/incorporation) treatments compared to residue removal or residue burning. Soil organic carbon (SOC), available nutrient content (N, P, and K), microbial count, and enzyme activities were also significantly higher in conservation tillage and residue-treated plots than without residue/burning treatments. The residue derived from both crops when was either retained/incorporated improved the soil organic carbon (0.80%) and resulted in a significant increase in SOC (73.9%) in the topsoil layer as compared to the conventional practice. The mean effect studies revealed that crop residue management practices and phosphorus levels significantly influenced wheat yield attributes and productivity. The higher grain yield of wheat was recorded in two treatments, i.e. the basal application of 60 kg P2O5 ha–1 without residue incorporation and the other with half the P-fertilizer (30 kg P2O5 ha–1) with rice residue only. The grain yield of wheat where the rice and wheat residue were either retained/incorporated without phosphorus application was at par with 30 and 60 kg P2O5ha–1. Phosphorus levels also significantly affected wheat productivity and available P content in the soil. Therefore, results suggested that crop residue retention following the conservation tillage approach improved the yield of wheat cultivated in the rice–wheat cropping system.
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| 5. |
- Jayne, David R W, et al.
(författare)
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Glomerulonephritides.
- 2014
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; 29 Suppl 3, s. 27-29
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Konferensbidrag (refereegranskat)
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| 6. |
- Kumar, A. Naresh, et al.
(författare)
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Upgrading the value of anaerobic fermentation via renewable chemicals production : A sustainable integration for circular bioeconomy
- 2022
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 806, part 1
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Forskningsöversikt (refereegranskat)abstract
- The single bioprocess approach has certain limitations in terms of process efficiency, product synthesis, and effective resource utilization. Integrated or combined bioprocessing maximizes resource recovery and creates a novel platform to establish sustainable biorefineries. Anaerobic fermentation (AF) is a well-established process for the transformation of organic waste into biogas; conversely, biogas CO2 separation is a challenging and cost-effective process. Biological fixation of CO2 for succinic acid (SA) mitigates CO2 separation issues and produces commercially important renewable chemicals. Additionally, utilizing digestate rich in volatile fatty acid (VFA) to produce medium-chain fatty acids (MCFAs) creates a novel integrated platform by utilizing residual organic metabolites. The present review encapsulates the advantages and limitations of AF along with biogas CO2 fixation for SA and digestate rich in VFA utilization for MCFA in a closed-loop approach. Biomethane and biohydrogen process CO2 utilization for SA production is cohesively deliberated along with the role of biohydrogen as an alternative reducing agent to augment SA yields. Similarly, MCFA production using VFA as a substrate and function of electron donors namely ethanol, lactate, and hydrogen are comprehensively discussed. A road map to establish the fermentative biorefinery approach in the framework of AF integrated sustainable bioprocess development is deliberated along with limitations and factors influencing for techno-economic analysis. The discussed integrated approach significantly contributes to promote the circular bioeconomy by establishing carbon-neutral processes in accord with sustainable development goals.
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| 7. |
- Mühleip, Alexander, et al.
(författare)
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Structural basis of mitochondrial membrane bending by the I–II–III2–IV2 supercomplex
- 2023
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 615:7954, s. 934-938
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Tidskriftsartikel (refereegranskat)abstract
- Mitochondrial energy conversion requires an intricate architecture of the inner mitochondrial membrane. Here we show that a supercomplex containing all four respiratory chain components contributes to membrane curvature induction in ciliates. We report cryo-electron microscopy and cryo-tomography structures of the supercomplex that comprises 150 different proteins and 311 bound lipids, forming a stable 5.8-MDa assembly. Owing to subunit acquisition and extension, complex I associates with a complex IV dimer, generating a wedge-shaped gap that serves as a binding site for complex II. Together with a tilted complex III dimer association, it results in a curved membrane region. Using molecular dynamics simulations, we demonstrate that the divergent supercomplex actively contributes to the membrane curvature induction and tubulation of cristae. Our findings highlight how the evolution of protein subunits of respiratory complexes has led to the I–II–III2–IV2 supercomplex that contributes to the shaping of the bioenergetic membrane, thereby enabling its functional specialization
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| 8. |
- Sharma, D. K., et al.
(författare)
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Different reinforcement strategies of hybrid surface composite AA6061/(B4C+MoS2) produced by friction stir processing : Verschiedene Strategien beim Rührreibschweißen zur Verstärkung von Hybrid‐Oberflächenverbundwerkstoffen aus AA6061/(B4C+MoS2)
- 2020
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Ingår i: Materialwissenschaft und Werkstofftechnik. - : Wiley-VCH Verlagsgesellschaft. - 0933-5137 .- 1521-4052. ; 51:11, s. 1493-1506
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Tidskriftsartikel (refereegranskat)abstract
- Aluminum surface composites have gained huge importance in material processing due to their noble tribological characteristics. The reinforcement of solid lubricant particles with hard ceramics further enriches the tribological characteristics of surface composites. In the current study, friction stir processing was chosen to synthesize hybrid surface composites of aluminum containing B4C and MoS2 particles with anticipated improved tribological behavior. B4C and MoS2 powder particles in 87.5: 12.5 ratio were reinforced into the AA6061 by hole and groove method. Microstructural observations indicated that reinforcement particles are well distributed in the matrix. The hardness and wear resistance of hybrid surface composites improved as compared to the base material, due to well distributed abrasive B4C and solid lubricant MoS2 particles in AA6061. The hybrid surface composites achieved ~32 % increased average hardness as compared to the base material. Hole method revealed ~13 % better wear resistance compared to the groove method for friction stir processed hybrid surface composite, attributing to an improved homogeneity of particle distribution shown by zigzag hole pattern. Moreover, friction stir processed AA6061 without reinforcement particles exhibited reduced hardness and wear resistance due to loss of strengthening precipitates during multi-pass friction stir processing. © 2020 Wiley-VCH GmbH
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| 9. |
- Sharma, Daulat Kumar, et al.
(författare)
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Recent Developments in Hybrid Surface Metal Matrix Composites Produced by Friction Stir Processing : A Review
- 2021
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Ingår i: Journal of tribology. - : ASME International. - 0742-4787 .- 1528-8897. ; 143:5, s. 050801-
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Tidskriftsartikel (refereegranskat)abstract
- The metal matrix composites combine the metallic properties of a tough and ductile matrix with properties of reinforcement particles, simultaneously develop the functional properties by proper selection of reinforcements for projected applications. However, hard ceramics reinforcements decrease toughness and ductility of soft matrix and restrict their wide applications. The surface metal matrix composites (SMMCs) preserve the matrix properties with added advanced surface properties by reinforcing particles only in the surface layer. The hybrid surface metal matrix composites (HSMMCs) with more than one reinforcement gained attention in material processing due to their noble tribological behavior and surface properties, which cannot be attained in mono composites. Conventional liquid-phase processing techniques to fabricate hybrid surface composites result in the formation of undesirable brittle compounds, detrimental to desirable properties of composites. Friction stir processing (FSP), a solid-state processing technique, has been used by many investigators using different reinforcements to fabricate mono as well as hybrid surface composites. Friction stir processed (FSPed) hybrid surface composites have not been extensively reviewed. The current review provides a comprehensive understanding of the latest developments of FSP in hybrid surface composites manufacturing. This paper review different reinforcement strategies in the fabrication of FSPed hybrid surface composites and also the effects of single-pass, multipass, and change in pass direction on microstructure and resultant properties. Finally, future directions and challenges to FSPed hybrid surface composites are summarized. This review article containing important information on hybrid surface composites fabrication by FSP will be useful to academicians and investigators in the field.
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| 10. |
- Sharma, Manish, et al.
(författare)
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Older Patients with Myeloma Derive Similar Benefit from Autologous Transplantation
- 2014
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 20:11, s. 1796-1803
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Tidskriftsartikel (refereegranskat)abstract
- Autologous hematopoietic cell transplantation (AHCT) for plasma cell myeloma is performed less often in people >70 years old than in people <= 70 years old. We analyzed 11,430 AHCT recipients for plasma cell myeloma prospectively reported to the Center for International Blood and Marrow Transplant Research between 2008 and 2011, representing the majority of US AHCT activity during this period. Survival (OS) was compared in 3 cohorts: ages 18 to 59 years (n = 5818), 60 to 69 years (n = 4666), and >70 years (n = 946). Median OS was not reached for any cohort. In multivariate analysis, increasing age was associated with mortality (P = .0006). Myeloma-specific mortality was similar among cohorts at 12%, indicating an age-related effect on nonmyeloma mortality. Analyses were performed in a representative subgroup comparing relapse rate, progression-free survival (PFS), and nonrelapse mortality (NRM). One-year NRM was 0% for age >70 years and 2% for other ages (P = not significant). The three-year relapse rate was 56% in age 18 to 59 years, 61% in age 60 to 69 years, and 63% age >70 (P = not significant). Three-year PFS was similar at 42% in age 18 to 59 years, 38% in age 60 to 69 years, and 33% in age >70 years (P = not significant). Postrelapse survival was significantly worse for the older cohort (P = .03). Older subjects selected for AHCT derived similar antimyeloma benefit without worse NRM, relapse rate, or PFS.
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