↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Shaw VR) "

Sökning: WFRF:(Shaw VR)

Resultat 1-6 av 6

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	Mayor, NP, et al. (författare) Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation 2021 Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 39:21, s. 2397- Tidskriftsartikel (refereegranskat)
2.	Asim, M, et al. (författare) Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer 2017 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1, s. 374- Tidskriftsartikel (refereegranskat)abstract Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we demonstrate a direct requirement for the androgen receptor (AR) to maintain HR gene expression and HR activity in prostate cancer. We show that PARP-mediated repair pathways are upregulated in prostate cancer following androgen-deprivation therapy (ADT). Furthermore, upregulation of PARP activity is essential for the survival of prostate cancer cells and we demonstrate a synthetic lethality between ADT and PARP inhibition in vivo. Our data suggest that ADT can functionally impair HR prior to the development of castration resistance and that, this potentially could be exploited therapeutically using PARP inhibitors in combination with androgen-deprivation therapy upfront in advanced or high-risk prostate cancer.
3.	Bhangu, A, et al. (författare) Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study 2018 Ingår i: The Lancet. Infectious diseases. - : Elsevier. - 1474-4457 .- 1473-3099. ; 18:5, s. 516-525 Tidskriftsartikel (refereegranskat)
4.	Han, Y, et al. (författare) Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis 2023 Ingår i: Nature communications. - 2041-1723. ; 14:1, s. 1069- Tidskriftsartikel (refereegranskat)
5.	Han, YH, et al. (författare) Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis 2023 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1, s. 1069- Tidskriftsartikel (refereegranskat)abstract Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly associated with immune-mediated disorders. In this study, we implemented multitrait joint analyses to genome-wide association summary statistics of PSC and numerous clinical and epidemiological traits to estimate the genetic contribution of each trait and genetic correlations between traits and to identify new lead PSC risk-associated loci. We identified seven new loci that have not been previously reported and one new independent lead variant in the previously reported locus. Functional annotation and fine-mapping nominated several potential susceptibility genes such as MANBA and IRF5. Network-based in silico drug efficacy screening provided candidate agents for further study of pharmacological effect in PSC.
6.	Thomas, HS, et al. (författare) 2019 swepub:Mat__t

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-6 av 6

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (5)

Typ av innehåll: refereegranskat (5)

Författare/redaktör: O'Neill, S (3); Cole, S. (2); Haddad, N. (2); Mahmoud, S. (2); Palma, A. (2); White, R. (2); visa fler...; Ye, J. (2); Ahmed, H. (2); Gupta, A. (2); Lim, H. (2); Aziz, NA (2); Kumar, S (2); Park, J (2); Wilson, M (2); Moore, R. (2); Zielinski, M. (2); Evans, D. (2); Roy, C. (2); Davies, R (2); Mohamed, A. (2); Mostafa, M. (2); Lopez, M. (2); Mohan, M. (2); Patel, P. (2); Hall, E (2); Ali, S (2); Mohammed, H (2); Mohammed, S (2); Negoi, I (2); Rickard, J (2); Zhu, C (2); Abbas, A. (2); Kumar, B (2); Carpio, J. (2); Sharma, A (2); Mohamed, M. (2); Muller, J. (2); Sanchez, D. (2); Mustafa, M (2); Abdelhady, S (2); Abdelkader, M. (2); Yang, J. (2); Cox, M (2); Sander, A. (2); Roy, S (2); King, S. (2); Ali, A. (2); Sacco, M (2); Walker, M (2); Khan, R. (2); visa färre...

Lärosäte: Karolinska Institutet (5); Umeå universitet (1)

Språk: Engelska (6)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy