| 1. |
- Tabassum, R, et al.
(författare)
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Genetic architecture of human plasma lipidome and its link to cardiovascular disease
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4329-
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Tidskriftsartikel (refereegranskat)abstract
- Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
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| 2. |
- Madenci, Emrah, et al.
(författare)
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Behavior of functionally graded carbon nanotube reinforced composite sandwich beams with pultruded GFRP core under bending effect
- 2024
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Ingår i: Frontiers in Materials. - : Frontiers. - 2296-8016. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- A novel generation of composite sandwich beams with laminated carbon fiber-reinforced polymer skins and pultruded glass fiber-reinforced polymer core materials was examined for their flexural behavior. The strength and failure mechanisms of the composite sandwich beams in flatwise and edgewise configurations were investigated using three-point static bending tests. These sophisticated composite structures must be designed and used in a variety of sectors, and our research provides vital insights into their performance and failure patterns. In comparison to the reference specimens (FGM-1), the carbon nanotube-reinforced specimens’ bending capacity was affected and ranged from −2.5% to 7.75%. The amount of the carbon nanotube addition had a substantial impact on the beams’ application level and load-carrying capacity. Particularly, the application of 0.5 wt% additive in the outermost fiber region of the beams, such as in FGM-4, led to an increase in the bending capacity. However, the stiffness values at the maximum load were decreased by 0.3%–18.6% compared to FGM-1, with the minimum level of the decrease in FGM-4. The experimental results were compared with the theoretical calculations based on the high-order shear deformation theory, which yielded an approximation between 11.99% and 12.98% by applying the Navier’s solution.
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| 3. |
- Madenci, Emrah, et al.
(författare)
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Experimental investigation and analytical verification of buckling of functionally graded carbon nanotube-reinforced sandwich beams
- 2024
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Ingår i: Heliyon. - : Elsevier. - 2405-8440. ; 10:8
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Tidskriftsartikel (refereegranskat)abstract
- Carbon nanotube (CNT) reinforcement can lead to a new way to enhance the properties of composites by transforming the reinforcement phases into nanoscale fillers. In this study, the buckling response of functionally graded CNT-reinforced composite (FG-CNTRC) sandwich beams was investigated experimentally and analytically. The top and bottom plates of the sandwich beams were composed of carbon fiber laminated composite layers and hard core. The hard core was made of a pultruded glass fiber-reinforced polymer (GFRP) profile. The layers of FG-CNTRC surfaces were reinforced with different proportions of CNT. The reference sample was made of only a pultruded GFRP profile. In the study, the reference sample and four samples with CNT were tested under compression. The largest buckling load difference between the reference sample and the sample with CNT was 37.7%. The difference between the analytical calculation results and experimental results was obtained with an approximation of 0.49%–4.92%. Finally, the buckling, debonding, interlaminar cracks, and fiber breakage were observed in the samples.
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| 4. |
- Murzin, D. Yu., et al.
(författare)
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Arabinogalactan hydrolysis and hydrolytic hydrogenation usingfunctionalized carbon materials
- 2015
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Ingår i: Catalysis Today. - : Elsevier BV. - 0920-5861 .- 1873-4308. ; 257, s. 169-176
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Tidskriftsartikel (refereegranskat)abstract
- Hydrolysis of the hemicellulose arabinogalactan was studied in this work over several functionalized carbon materials, which were specifically treated to increase their acidities. Hydrolytic hydrogenation of arabinogalactan was investigated using the same materials in a mechanical mixture with ruthenium supported on active carbon. Application of these mixtures resulted in formation of polyols, suppressing simultaneously the generation of side products hydroxymethylfurfural (HMF) and furfural. Formation of high molecular weight compounds (aggregates of sugars and humins) was still quite substantial with a mechanical mixture of Ru/C and a carbon material prepared from sucrose by activation with zinc chloride to increase porosity. Post-treatment of this carbonaceous material with sulphuric acid significantly influenced kinetics of high molecular weight products formation resulting also in elevation of sugar alcohols yields.
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| 5. |
- Özkılıç, Yasin Onuralp, et al.
(författare)
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Influence of ceramic waste powder on shear performance of environmentally friendly reinforced concrete beams
- 2024
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Ingår i: Scientific Reports. - : Springer. - 2045-2322. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- This investigation considered the usability of ceramic waste powder (CWP) in altered quantities in reinforced concrete beams (RCBs). In this way, it was aimed to reduce the environmental impacts of concrete by using CWP as a raw material in RCBs. 12 small-scale shear RCBs with the dimensions of 100 × 150 × 1000 mm were tested in this study. The variations of stirrups spacing and CWP ratio were examined in these specimens. The percentages of CWP by weight utilized in RCBs were 10%, 20%, and 30%, and stirrups spacings were adopted as 270 mm, 200 mm, and 160 mm. At the end of the study, it was determined that more than 10% CWP additive negatively affected the RCBs’ compressive strength. The load-carrying capacity reduced between 30.3% and 59.4% when CWP increased from 0% to 30% as compared to RCB with stirrups spacing of 270 mm without CWP. However, compared to RCB with stirrups spacings of 200 mm and 160 mm without CWP, there were decreases in the load-carrying capacity as 21.4%–54.3% and 18.6%–54.6%, respectively. While the CWP ratio increased, the specimens with 160 mm, 200 mm, and 270 mm stirrups spacings obtained a lower maximum load value. However, with the increase of the CWP ratio in the specimens with 160 mm stirrups spacing, RCBs reached the maximum load-carrying capacity at an earlier displacement value. When stirrups spacing was selected as 270 mm, it was observed that the maximum load-carrying capacity of RCBs reached at a similar displacement value as the CWP ratio increased. Besides, it was resulted that the bending stiffness of RCBs reduced as the quantity of CWP enhanced. The bending stiffness decreased by 29.1% to 66.4% in the specimens with 270 mm stirrups spacing, 36.3% to 20.2% with 200 mm stirrups spacing, and 10.3% to 36.9% with 160 mm stirrups spacing. As an implication of the experiments, the use of CWP up to 10% in RCBs was realized as an economical and environmental approach and is suggested. There is some evidence to report that making use of CWP may be considered to be ecologically benign. This is due to the fact that reusing CWP may significantly reduce CO2 emissions, save energy, and reduce total power consumption. Furthermore, the experimental results were compared to the analytical calculations.
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