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| 4. |
- Wilck, M, et al.
(författare)
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A Phase 3, Randomized, Double-Blind, Comparator-Controlled Study to Evaluate Safety, Tolerability, and Immunogenicity of V114, a 15-Valent Pneumococcal Conjugate Vaccine, in Allogeneic Hematopoietic Cell Transplant Recipients (PNEU-STEM)
- 2023
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Ingår i: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. - 1537-6591. ; 77:8, s. 1102-1110
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Antzutkin, Oleg, et al.
(författare)
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2-dimensional side-band separation in magic-angle-spinning NMR
- 1995
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Ingår i: Journal of Magnetic Resonance - Series A. - : Elsevier BV. - 1064-1858 .- 1096-0864. ; 115:1, s. 7-19
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Tidskriftsartikel (refereegranskat)abstract
- A new method for separating isotropic and anisotropic chemical-shift interactions in magic-angle-spinning NMR is presented. The new method is based upon manipulation of the phases of spinning sidebands using sequences of five π pulses. A two-dimensional pulse scheme separates the spinning sidebands by order. The amplitudes of the spinning sidebands may be analyzed to obtain the principal values of the chemical-shift anisotropy. For sites with many sidebands, it is possible to improve the signal-to-noise ratio considerably by skew projection of the two-dimensional spectrum. Experimental demonstrations are presented.
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| 7. |
- Fung, Y.L., et al.
(författare)
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Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage.
- 2013
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Ingår i: Vox Sanguinis. - : Wiley. - 1423-0410 .- 0042-9007. ; 105:2, s. 150-158
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND OBJECTIVES: Transfusion of blood products in particular older products is associated with patient morbidity. Previously, we demonstrated a higher incidence of acute lung injury in lipopolysaccharide-treated sheep transfused with stored blood products. As transfusion following haemorrhage is more common, we aimed to determine whether a 'first hit' of isolated haemorrhage would precipitate similar detrimental effects following transfusion and also disrupt haemostasis. MATERIALS AND METHODS: Anaesthetized sheep had 33% of their total blood volume collected into Leukotrap bags (Pall Medical), which were processed into packed red blood cells and cross-matched for transfusion into other sheep. After 30 mins, the sheep were resuscitated with either: fresh (<5 days old) or stored (35-42 days old) ovine blood followed by 4% albumin to replacement volume, albumin alone or normal saline alone and monitored for 4 h. RESULTS: The first hit of haemorrhage precipitated substantial decreases in mean arterial pressure however haemostasis was preserved. Transfusion of stored ovine blood induced (1) transient pulmonary arterial hypertension but no oedema and (2) reduced fibrinogen levels more than fresh blood, but neither induced coagulopathy. Thus, transfusion of stored blood affected pulmonary function even in the absence of overt organ injury. CONCLUSION: The fact that stored blood transfusions: (1) did not induce acute lung injury in contrast to previous lipopolysaccharide-primed animal models identifies the 'first hit' as an important determinant of the severity of transfusion-mediated injury; (2) impaired pulmonary dynamics verifies the sensitivity and vulnerability of the pulmonary system to injury.
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| 8. |
- Song, Z., et al.
(författare)
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Conformational transitions of the phosphodiester backbone in native DNA: two-dimensional magic-angle-spinning 31P-NMR of DNA fibers
- 1997
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Ingår i: Biophysical Journal. - 0006-3495 .- 1542-0086. ; 73:3, s. 1539-1552
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Tidskriftsartikel (refereegranskat)abstract
- Solid-state 31P-NMR is used to investigate the orientation of the phosphodiester backbone in NaDNA-, LiDNA-, MgDNA-, and NaDNA-netropsin fibers. The results for A- and B-DNA agree with previous interpretations. We verify that the binding of netropsin to NaDNA stabilizes the B form, and find that in NaDNA, most of the phosphate groups adopt a conformation typical of the A form, although there are minor components with phosphate orientations close to the B form. For LiDNA and MgDNA samples, on the other hand, we find phosphate conformations that are in variance with previous models. These samples display x-ray diffraction patterns that correspond to C-DNA. However, we find two distinct phosphate orientations in these samples, one resembling that in B-DNA, and one displaying a twist of the PO4 groups about the O3-P-O4 bisectors. The latter conformation is not in accordance with previous models of C-DNA structure.
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