| 1. |
- Jhun, Mina-A, et al.
(författare)
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A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
- 2021
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups. Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.
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| 2. |
- Yue, Jincheng, et al.
(författare)
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Role of atypical temperature-responsive lattice thermal transport on the thermoelectric properties of antiperovskites Mg3XN (X = P, As, Sb, Bi)
- 2024
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Ingår i: Materials Today Physics. - : ELSEVIER. - 2542-5293. ; 41
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Tidskriftsartikel (refereegranskat)abstract
- Antiperovskite materials have garnered significant attention due to their rich array of physical properties. In this study, we undertake a theoretical exploration into the phase stabilities, and the thermal and electronic transport properties of magnesium-based antiperovskite Mg3XN (X = P, As, Sb, and Bi) based on density functional theory (DFT) calculations, aiming at designing promising thermoelectric materials. The Mg3PN and Mg3AsN possess potential lattice distortion and strong quartic anharmonicity associated with the tilting displacement of Mg6N octahedra. After phonon renormalization, the thermal conductivity of Mg3PN and Mg3AsN exhibits relatively subdued temperature responsiveness with T-0.47 and T-0.62, respectively. Of note, the thermal conductivity of Mg3BiN drops the lowest at 900 K because of its distinctive rattle-dominated flat vibrational modes and strong temperature responsiveness with T-0.96, despite having a high initial value. Moreover, the combination of multiple degeneracy pockets and lighter dispersion band edges in Mg3XN ensures high Seebeck coefficient and impressive electronic conductivity, respectively. Ultimately, Mg3BiN achieves the optimal power factor, which also guarantees its excellent thermoelectric performance with the ZT values of 1.03 and 1.01 for n-type and ptype at 900 K, respectively. Our findings shed light on the significant impact of unconventional temperatureresponsive lattice thermal conductivity on thermoelectric materials for high-temperature applications.
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