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- Strakova, A., et al.
(författare)
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Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
- 2020
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.
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- Butler, Geraldine, et al.
(författare)
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Evolution of pathogenicity and sexual reproduction in eight Candida genomes.
- 2009
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 459:7247, s. 657-62
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Tidskriftsartikel (refereegranskat)abstract
- Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
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- Reimold, W U, et al.
(författare)
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Laser argon dating of melt breccias from the Siljan impact structure, Sweden : Implications for a possible relationship to Late Devonian extinction events
- 2005
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Ingår i: Meteoritics and Planetary Science. - : Wiley. - 1086-9379 .- 1945-5100. ; 40:4, s. 591-607
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Tidskriftsartikel (refereegranskat)abstract
- In earlier studies, the 65-75 km diameter Si1jan impact structure in Sweden has been linked to the Late Devonian mass extinction event. The Siljan impact event has previously been dated by K-Ar and Ar-Ar chronology at 342-368 Ma, with the commonly quoted age being 362.7 +/- 2.2 Ma (2 sigma, recalculated using currently accepted decay constants). Until recently, the accepted age for the Frasnian/Famennian boundary and associated extinction event was 364 Ma, which is within error limits of this earlier Si1jan age. Here we report new Ar-Ar ages extracted by laser spot and laser step heating techniques for several melt breccia samples from Si1jan (interpreted to be impact melt breccia). The analytical results show some scatter, which is greater in samples with more extensive alteration; these samples generally yield younger ages. The two samples with the least alteration yield the most reproducible weighted mean ages: one yielded a laser spot age of 377.2 +/- 2.5 Ma (95% confidence limits) and the other yielded both a laser spot age of 376.1 +/- 2.8 Ma (95% confidence limits) and a laser stepped heating plateau age over 70.6% (39)Ar release of 377.5 +/- 2.4 Ma (2 sigma). Our conservative estimate for the age of Siljan is 377 2 Ma (95% confidence limits), which is significantly different from both the previously accepted age for the Frasnian/Famennian (F/F) boundary and the previously quoted age of Siljan. However, the age of the F/F boundary has recently been revised to 374.5 +/- 2.6 Ma by the International Commission for Stratigraphy, which is, within error, the same as our new age. However, the currently available age data are not proof that there was a connection between the Si1jan impact event and the F/F boundary extinction. This new result highlights the dual problems of dating meteorite impacts where fine-grained melt rocks are often all that can be isotopically dated, and constraining the absolute age of biostratigraphic boundaries, which can only be constrained by age extrapolation. Further work is required to develop and improve the terrestrial impact age record and test whether or not the terrestrial impact flux increased significantly at certain times, perhaps resulting in major extinction events in Earth's biostratigraphic record.
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- Sherlock, S, et al.
(författare)
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Panel discussion
- 1995
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Ingår i: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 23, s. 37-40
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Blagrove, Marcus S. C., et al.
(författare)
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Potential for Zika virus transmission by mosquitoes in temperate climates
- 2020
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Ingår i: Proceedings of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8452 .- 1471-2954. ; 287:1930
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Tidskriftsartikel (refereegranskat)abstract
- Mosquito-borne Zika virus (ZIKV) transmission has almost exclusively been detected in the tropics despite the distributions of its primary vectors extending farther into temperate regions. Therefore, it is unknown whether ZIKV's range has reached a temperature-dependent limit, or if it can spread into temperate climates. Using field-collected mosquitoes for biological relevance, we found that two common temperate mosquito species,Aedes albopictusandOchlerotatus detritus, were competent for ZIKV. We orally exposed mosquitoes to ZIKV and held them at between 17 and 31 degrees C, estimated the time required for mosquitoes to become infectious, and applied these data to a ZIKV spatial risk model. We identified a minimum temperature threshold for the transmission of ZIKV by mosquitoes between 17 and 19 degrees C. Using these data, we generated standardized basic reproduction numberR(0)-based risk maps and we derived estimates for the length of the transmission season for recent and future climate conditions. Our standardizedR(0)-based risk maps show potential risk of ZIKV transmission beyond the current observed range in southern USA, southern China and southern European countries. Transmission risk is simulated to increase over southern and Eastern Europe, northern USA and temperate regions of Asia (northern China, southern Japan) in future climate scenarios.
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