| 1. |
- Lewis, Cathryn M, et al.
(författare)
-
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II : Schizophrenia
- 2003
-
Ingår i: American Journal of Human Genetics. - 0002-9297 .- 1537-6605. ; 73:1, s. 34-48
-
Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk<.000417). Two aggregate criteria for linkage were also met (clusters of nominally significant P values that did not occur in 1,000 replicates of the entire data set with no linkage present): 12 consecutive bins with both P(AvgRnk) and P(ord)<.05, including regions of chromosomes 5q, 3p, 11q, 6p, 1q, 22q, 8p, 20q, and 14p, and 19 consecutive bins with P(ord)<.05, additionally including regions of chromosomes 16q, 18q, 10p, 15q, 6q, and 17q. There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
|
|
| 2. |
- Ng, M Y M, et al.
(författare)
-
Meta-analysis of 32 genome-wide linkage studies of schizophrenia
- 2009
-
Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 14:8, s. 774-785
-
Tidskriftsartikel (refereegranskat)abstract
- A genome scan meta-analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for each bin across studies and determined the empirical probability of a given summed rank (P(SR)) by simulation. Suggestive evidence for linkage was observed in two single bins, on chromosomes 5q (142-168 Mb) and 2q (103-134 Mb). Genome-wide evidence for linkage was detected on chromosome 2q (119-152 Mb) when bin boundaries were shifted to the middle of the previous bins. The primary analysis met empirical criteria for 'aggregate' genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q. In a secondary analysis of 22 studies of European-ancestry samples, suggestive evidence for linkage was observed on chromosome 8p (16-33 Mb). Although the newer genome-wide association methodology has greater power to detect weak associations to single common DNA sequence variants, linkage analysis can detect diverse genetic effects that segregate in families, including multiple rare variants within one locus or several weakly associated loci in the same region. Therefore, the regions supported by this meta-analysis deserve close attention in future studies.
|
|
| 3. |
- Sigmundsson, F., et al.
(författare)
-
Segmented lateral dyke growth in a rifting event at Bardarbunga volcanic system, Iceland
- 2015
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 517:7533
-
Tidskriftsartikel (refereegranskat)abstract
- Crust at many divergent plate boundaries forms primarily by the injection of vertical sheet-like dykes, some tens of kilometres long(1). Previous models of rifting events indicate either lateral dyke growth away from a feeding source, with propagation rates decreasing as the dyke lengthens(2-4), or magma flowing vertically into dykes from an underlying source(5,6), with the role of topography on the evolution of lateral dykes not clear. Here we show how a recent segmented dyke intrusion in the Bardarbunga volcanic system grew laterally for more than 45 kilometres at a variable rate, with topography influencing the direction of propagation. Barriers at the ends of each segment were overcome by the build-up of pressure in the dyke end; then a new segment formed and dyke lengthening temporarily peaked. The dyke evolution, which occurred primarily over 14 days, was revealed by propagating seismicity, ground deformation mapped by Global Positioning System(GPS), interferometric analysis of satellite radar images (InSAR), and graben formation. The strike of the dyke segments varies from an initially radial direction away from the Bardarbunga caldera, towards alignment with that expected from regional stress at the distal end. A model minimizing the combined strain and gravitational potential energy explains the propagation path. Dyke opening and seismicity focused at the most distal segment at any given time, and were simultaneous with magma source deflation and slow collapse at the Bardarbunga caldera, accompanied by a series of magnitude M > 5 earthquakes. Dyke growth was slowed down by an effusive fissure eruption near the end of the dyke. Lateral dyke growth with segment barrier breaking by pressure build-up in the dyke distal end explains how focused upwelling of magma under central volcanoes is effectively redistributed over long distances to create new upper crust at divergent plate boundaries.
|
|
| 4. |
- Auriac, A., et al.
(författare)
-
Iceland rising : Solid Earth response to ice retreat inferred from satellite radar interferometry and visocelastic modeling
- 2013
-
Ingår i: Journal of Geophysical Research. - : American Geophysical Union (AGU). - 0148-0227 .- 2156-2202 .- 2169-9313 .- 2169-9356. ; 118:4, s. 1331-1344
-
Tidskriftsartikel (refereegranskat)abstract
- A broad uplift occurs in Iceland in response to the retreat of ice caps, which began circa 1890. Until now, this deformation signal has been measured primarily using GPS at points some distance away from the ice caps. Here, for the first time we use satellite radar interferometry (interferometric synthetic aperture radar) to constrain uplift of the ground all the way up to the edge of the largest ice cap, Vatnajokull. This allows for improved constraints on the Earth rheology, both the thickness of the uppermost Earth layer that responds only in an elastic manner and the viscosity below it. The interferometric synthetic aperture radar velocities indicate a maximum displacement rate of 24 +/- 4 and 31 +/- 4 mm/yr at the edge of Vatnajokull, during 1995-2002 and 2004-2009, respectively. The fastest rates occur at outlet glaciers of low elevation where ice retreat is high. We compare the observations with glacial isostatic adjustment models that include the deglaciation history of the Icelandic ice caps since 1890 and two Earth layers. Using a Bayesian approach, we derived probability density functions for the average Earth model parameters for three satellite tracks. Based on our assumptions, the three best fit models give elastic thicknesses in the range of 15-40 km, and viscosities ranging from 4-10x1018 Pa s.
|
|
| 5. |
- de Zeeuw-van Dalfsen, E., et al.
(författare)
-
Geodetic data shed light on ongoing caldera subsidence at Askja, Iceland
- 2013
-
Ingår i: Bulletin of Volcanology. - : Springer Science and Business Media LLC. - 0258-8900 .- 1432-0819. ; 75:5
-
Tidskriftsartikel (refereegranskat)abstract
- Subsidence within the main caldera of Askja volcano in the North of Iceland has been in progress since 1983. Here, we present new ground- and satellite-based deformation data, which we interpret together with new and existing micro-gravity data, to help understand which processes may be responsible for the unrest. From 2003 to 2007, we observe a net micro-gravity decrease combined with subsidence and from 2007 to 2009 we observe a net micro-gravity increase while the subsidence continues. We infer subsidence is caused by a combination of a cooling and contracting magma chamber at a divergent plate boundary. Mass movements at active volcanoes can be caused by several processes, including water table/lake level movements, hydrothermal activity and magma movements. We suggest that, here, magma movement and/or a steam cap in the geothermal system of Askja at depth are responsible for the observed micro-gravity variations. In this respect, we rule out the possibility of a shallow intrusion as an explanation for the observed micro-gravity increase but suggest magma may have flowed into the residing shallow magma chamber at Askja despite continued subsidence. In particular, variable compressibility of magma residing in the magma chamber as well as compressibility of the surrounding rock may be the reason why this additional magma did not create any detectable surface deformation.
|
|
| 6. |
- Drouin, V., et al.
(författare)
-
Deformation in the Northern Volcanic Zone of Iceland 2008-2014: An interplay of tectonic, magmatic, and glacial isostatic deformation
- 2017
-
Ingår i: Journal of Geophysical Research-Solid Earth. - : American Geophysical Union (AGU). - 2169-9313 .- 2169-9356. ; 122:4, s. 3158-3178
-
Tidskriftsartikel (refereegranskat)abstract
- GPS measurements spanning 2008 to 2014 are used to derive the surface velocity field across the Northern Volcanic Zone (NVZ) of Iceland, a subaerial part of the divergent boundary between the North American and Eurasian plates. No volcanic activity nor magmatic intrusions were detected in the zone during this time period. We infer an extensional rate of 17.4(-0.3)(+0.2) mm/yr in direction 292.0(-0.6)(+0.5 degrees),consistent with the results of previous studies and current plate motion models including MORVEL2010 and GEODVEL2010. The horizontal velocity field reveals about 50 km wide stretching zone caused by the divergent plate movements. Glacial isostatic adjustment (GIA) induces uplift of over 20 mm/yr at the northern edge of Vatnajokull ice cap and 3-4 mm/yr horizontal motion directed away from the ice cap. Deformation in the NVZ between 2008 and 2014 can be reproduced by a combination of models relating to several different processes: (i) Mogi sources for volcanic and geothermal deformation at the Askja and Krafla volcanoes, (ii) scaled version of a velocity field derived from a glacial isostatic model, and (iii) simple arctangent-based model for secular plate spreading. We find the approximate location of the plate boundary spreading axis as well as its locking depth. The spreading axis lies through the Krafla, Fremrinamar, and Askja central volcanoes, the most active ones in the NVZ. It does not appear to follow the general direction of each fissure swarm but rather to change direction at the central volcanoes. The locking depth is on average within the 7-9 km range.
|
|
| 7. |
- Elmose, Signe F., et al.
(författare)
-
Radiological Definitions of Sagittal Plane Segmental Instability in the Degenerative Lumbar Spine - A Systematic Review
- 2023
-
Ingår i: Global Spine Journal. - : Sage Publications. - 2192-5682 .- 2192-5690. ; 13:2, s. 523-533
-
Forskningsöversikt (refereegranskat)abstract
- Study Design: Systematic Review.Objective: To collect and group definitions of segmental instability, reported in surgical studies of patients with lumbar spinal stenosis (LSS) and/or lumbar degenerative spondylolisthesis (LDS). To report the frequencies of these definitions. To report on imaging measurement thresholds for instability in patients and compare these to those reported in biomechanical studies and studies of spine healthy individuals.To report on studies that include a reliability study.Methods: This review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Studies eligible for inclusion were clinical and biomechanical studies on adult patients with LDS and/or LSS who underwent surgical treatment and had data on diagnostic imaging. A systematic literature search was conducted in relevant literature databases. Full text screening inclusion criteria was definition of segmental instability or any synonym. Two reviewers independently screened articles in a two-step process. Data synthesis presented by tabulate form and narrative synthesis.Results: We included 118 studies for data extraction, 69% were surgical studies with decompression or fusion as interventions, 31% non-interventional studies. Grouping the definitions of segmental instability according similarities showed that 24% defined instability by dynamic sagittal translation, 26% dynamic translation and dynamic angulation, 8% used a narrative definition. Comparison showed that non-interventional studies with a healthy population more often had a narrative definition.Conclusion: Despite a reputation of non-consensus, segmental instability in the degenerative lumbar spine can radiologically be defined as > 3 mm dynamic sagittal translation.
|
|
| 8. |
- Geirsson, H., et al.
(författare)
-
Overview of results from continuous GPS observations in Iceland from 1995 to 2010
- 2010
-
Ingår i: Jökull. - 0449-0576. ; 60:1, s. 1-21
-
Tidskriftsartikel (refereegranskat)abstract
- Iceland is a natural laboratory for a variety of processes associated with crustal deformation, such as earthquakes, magmatic events, tectonic plate motions, and glacial load changes. Continuous GPS (CGPS) measurements started in Iceland in 1995, and since then data from the network have helped to shed light on many different active deformation processes. The number of CGPS sites in Iceland tripled during 2006–2008, as a result of an international collaborative effort coordinated by Icelandic scientists. By early 2010 the number of CGPS stations in Iceland had reached 64, located primarily around and within the North- American–Eurasian plate boundary zone. Since its initiation, the CGPS network has played an important role in monitoring volcanoes and seismogenic areas, most notably during the 2009–2010 Eyjafjallajökull volcano unrest. Plate spreading of up to 2 cm per year usually dominates the horizontal motion observed at the CGPS sites, while uplift is observed at many of the stations due to recent retreat of the Icelandic ice caps. Co-seismic and post-seismic deformation of the largest earthquakes in 2000 and 2008 in the South Iceland Seismic Zone were captured by the network, and high-rate (1 Hz) CGPS observations helped to identify two magnitude 6 mainshocks in 2008 that were separated in time by only 2–3 seconds. The CGPS network has thus enabled us to monitor deformation occurring over days to months caused by migration of magma or fluids, post-seismic transients, rapid deformation caused by earthquakes and eruptions, as well as the long term plate spreading signal.
|
|
| 9. |
- Grapenthin, R., et al.
(författare)
-
Pressure sources versus surface loads: Analyzing volcano deformation signal composition with an application to Hekla volcano, Iceland
- 2010
-
Ingår i: Geophysical Research Letters. - 0094-8276. ; 37
-
Tidskriftsartikel (refereegranskat)abstract
- The load of lava emplaced over periods of decades to centuries induces a gradual viscous response of the Earth resulting in measurable deformation. This effect should be considered in source model inversions for volcanic areas with large lava production and flow emplacement in small centralized regions. If deformation data remain uncorrected, constructive load and pressure source interference may result in an overestimate of depth and volume of a magma reservoir whereas destructive signal interference may cause these values to be underestimated. In both cases the source geometry preference could be biased. The ratio of horizontal and vertical displacements aids the identification of composite signals. We provide a method to quantify and remove the lava load deformation signals, using deformation at Hekla volcano, Iceland as an example.
|
|
| 10. |
|
|
