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- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
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| 3. |
- Chen, Wei-Min, et al.
(författare)
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Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
- 2008
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Ingår i: Journal of Clinical Investigation. - 0021-9738. ; Jun 2, s. 2620-2628
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Tidskriftsartikel (refereegranskat)abstract
- Identifying the genetic variants that regulate fasting glucose concentrations may further our understanding of the pathogenesis of diabetes. We therefore investigated the association of fasting glucose levels with SNPs in 2 genome-wide scans including a total of 5,088 nondiabetic individuals from Finland and Sardinia. We found a significant association between the SNP rs563694 and fasting glucose concentrations (P = 3.5 x 10(-7)). This association was further investigated in an additional 18,436 nondiabetic individuals of mixed European descent from 7 different studies. The combined P value for association in these follow-up samples was 6.9 x 10(-26), and combining results from all studies resulted in an overall P value for association of 6.4 x 10(-33). Across these studies, fasting glucose concentrations increased 0.01-0.16 mM with each copy of the major allele, accounting for approximately 1% of the total variation in fasting glucose. The rs563694 SNP is located between the genes glucose-6-phosphatase catalytic subunit 2 (G6PC2) and ATP-binding cassette, subfamily B (MDR/TAP), member 11 (ABCB11). Our results in combination with data reported in the literature suggest that G6PC2, a glucose-6-phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation.
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| 4. |
- Janhunen, Pekka, et al.
(författare)
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Electric Solar Wind Sail in tailwind
- 2011
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Ingår i: EPSC-DPS Joint Meeting 2011.
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Konferensbidrag (refereegranskat)abstract
- The Electric Solar Wind Sail (E-sail) is a novelpropulsion concept that enables faster space travel tomany solar system targets. E-sail uses charged solarwind particles as the source of its propulsion. This isachieved by deploying long, conducting and chargedtethers, which get pushed by the solar wind byCoulomb drag [1].E-sail technology is being developed to technicalreadiness level (TRL) 4-5 by the European Union’sSeventh Framework Programme for Research andTechnological Development, EU FP7, in a projectnamed ESAIL (http://www.electric-sailing.fi/fp7).Prototypes of the key parts are to be produced. Thedesign will be scalable so that a real solar winddemonstration mission could be scaled up from them.We review here the latest results of the constantlyevolving E-sail project.
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| 6. |
- Nilsson, Andreas, et al.
(författare)
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A simple improvement on Silver's heuristic for the joint replenishment problem
- 2008
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Ingår i: Journal of the Operational Research Society. - : Informa UK Limited. - 0160-5682 .- 1476-9360. ; 59:10, s. 1415-1421
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we revisit the well-known joint replenishment problem. There is a family of items with a major fixed cost associated with any replenishment of the family and a minor, (item-dependent) setup cost for each item that is included in the replenishment. In contrast with optimization methods and sophisticated (iterative) heuristics that have been presented in the literature, we present a simple (including ease of understanding) improvement routine to be used in conjunction with the original, simple approach advocated by one of the authors 30 years ago. Tests on 48,000 examples reveal that the improvement routine does, indeed, substantially improve performance and with relatively little extra computational effort. Thus, it should be of particular interest to practitioners and for teaching materials.
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