| 1. |
- Björkqvist, Maria, et al.
(författare)
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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
- 2008
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 205, s. 1869-1877
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Tidskriftsartikel (refereegranskat)abstract
- Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread evidence of innate immune activation detectable in plasma throughout the course of HD. Interleukin 6 levels were increased in HD gene carriers with a mean of 16 years before the predicted onset of clinical symptoms. To our knowledge, this is the earliest plasma abnormality identified in HD. Monocytes from HD subjects expressed mutant huntingtin and were pathologically hyperactive in response to stimulation, suggesting that the mutant protein triggers a cell-autonomous immune activation. A similar pattern was seen in macrophages and microglia from HD mouse models, and the cerebrospinal fluid and striatum of HD patients exhibited abnormal immune activation, suggesting that immune dysfunction plays a role in brain pathology. Collectively, our data suggest parallel central nervous system and peripheral pathogenic pathways of immune activation in HD.
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| 2. |
- Nygren, Mats, et al.
(författare)
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Spark plasma sintering of Zr- and Hf-borides with decreasing amounts of MoSi2 as sintering aid.
- 2008
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Ingår i: Journal of European Ceramic Society. ; 28:1287-1296
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Tidskriftsartikel (refereegranskat)abstract
- ZrB2- and HfB2-based composites contg. 1, 3, and 9 vol.% MoSi2 as sintering aid were densified by spark plasma sintering at temps. ranging from 1700 to 1950, with an applied pressure of 100 MPa. As-received ZrB2 and HfB2 powders were also sintered at temps. in the range of 2100-2200. Fully dense samples were obtained between 1750 and 1850 when MoSi2 was added. As-received ZrB2 powder was sintered to 98% at 2100. The microstructural features were investigated by SEM-EDS technique. SciC was detected in all the doped compns. along with significant amts. of oxide species (Hf/ZrO2 and SiO2). Vickers hardness and fracture toughness were measured by indentation technique on polished sections. The effect of the MoSi2 content on densification, microstructure, and mech. properties is discussed.
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| 3. |
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| 4. |
- Zullo, G., et al.
(författare)
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A novel multi-axial pressure sensor probe for measuring triaxial stress states inside soft materials
- 2021
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 21:10
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the concept, design, construction, and validation of a novel probe based on the hexadic disposition of six pressure sensors suitable for measuring triaxial stress states inside bulky soft materials. The measurement of triaxial stress states inside bulk materials such as brain tissue surrogates is a challenging task needed to investigate internal organs’ stress states and validate FE models. The purpose of the work was the development and validation of a 17 × 17 × 17 mm probe containing six pressure sensors. To do so, six piezoresistive pressure sensors of 6 mm diameter were arranged into an hexad at three cartesian axes and bisecting angles, based on the analytical solution of the stress tensor. The resulting probe was embedded in a soft silicone rubber of known characteristics, calibrated under cyclic compression and shear in three orientations, and statically validated with combined loads. A calibration matrix was computed, and validation tests allowed us to estimate Von Mises stress under combined stress with an error below 6%. Hence, the proposed probe design and method can give indications about the complex stress state developing internally to soft materials under triaxial high-strain fields, opening applications in the analysis of biological models or physical surrogates involving parenchyma organs.
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