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- Cachim, Afonso, et al.
(författare)
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Measuring adherence to inhaled control medication in patients with asthma : Comparison among an asthma app, patient self-report and physician assessment
- 2023
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Ingår i: Clinical and Translational Allergy. - : John Wiley & Sons. - 2045-7022. ; 13:2
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundPrevious studies have demonstrated the feasibility of using an asthma app to support medication management and adherence but failed to compare with other measures currently used in clinical practice. However, in a clinical setting, any additional adherence measurement must be evaluated in the context of both the patient and physician perspectives so that it can also help improve the process of shared decision making. Thus, we aimed to compare different measures of adherence to asthma control inhalers in clinical practice, namely through an app, patient self-report and physician assessment.MethodsThis study is a secondary analysis of three prospective multicentre observational studies with patients (≥13 years old) with persistent asthma recruited from 61 primary and secondary care centres in Portugal. Patients were invited to use the InspirerMundi app and register their inhaled medication. Adherence was measured by the app as the number of doses taken divided by the number of doses scheduled each day and two time points were considered for analysis: 1-week and 1-month. At baseline, patients and physicians independently assessed adherence to asthma control inhalers during the previous week using a Visual Analogue Scale (VAS 0–100).ResultsA total of 193 patients (72% female; median [P25–P75] age 28 [19–41] years old) were included in the analysis. Adherence measured by the app was lower (1 week: 31 [0–71]%; 1 month: 18 [0–48]%) than patient self-report (80 [60–95]) and physician assessment (82 [51–94]) (p < 0.001). A negligible non-significant correlation was found between the app and subjective measurements (ρ 0.118–0.156, p > 0.05). There was a moderate correlation between patient self-report and physician assessment (ρ = 0.596, p < 0.001).ConclusionsAdherence measured by the app was lower than that reported by the patient or the physician. This was expected as objective measurements are commonly lower than subjective evaluations, which tend to overestimate adherence. Nevertheless, the low adherence measured by the app may also be influenced by the use of the app itself and this needs to be considered in future studies.
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- Vicente, Guiomar, et al.
(författare)
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Sistema Inovador de Construção Metálica : FRAMEUP
- 2015
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Konferensbidrag (refereegranskat)abstract
- The methodology developed under the project FRAMEUP includes the construction of residential buildings from the top to the base, whose compartments are prefabricated modules. The construction begins with the execution of the roof, on the ground level, which is later on lifted, allowing from beneath the construction of the lower floors, while it protects them from the weather. The construction ends with the execution of the ground floor. It is adopted a framed structure with tubular sections for which the beam-to-column connections are developed and the columns-splices designed to facilitate and the use of this constructive methodology.
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- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Andrade, Pedro, et al.
(författare)
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Innovative system for the construction and management of student resisdences : Frameup system
- 2016
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Ingår i: IABSE CONGRESS, STOCKHOLM, 2016. - CH - 8093 Zürich, Switzerland : International Association for Bridge and Structural Engineering. - 9783857481444 ; , s. 1364-1370
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Konferensbidrag (refereegranskat)abstract
- Sweden has a strong demand on the construction of student accommodations and consequently significant efforts have been taken to increase and streamline construction methods. In addition, the fluctuation on the number of students admitted at each year, in each university, lead to periods of house shortage or, in opposition to that, to eventual surplus on the housing market. For these reasons urges finding a fast execution process in construction to fulfil the market needs, together with a housing mechanism of control which balances the students’ needs with the housing availability. In this sense, the Frameup system arises as a solution to solve both problems by combining a modular construction with an innovative execution process.The FRAMEUP buildings uses a steel frame in combination with prefabricated 3D modules - fully equipped and suitable for student accommodations – which are assembled by starting from the roof to the 1st floor. The existence of the lifting system permits the erection of the building, promoting each time the building is lifted, a clearance of one-floor-height, at ground level, for the assembly of a new floor. The procedure is repeated several times, according to the number of floors, until the 1st floor of the building, the last floor of the execution sequence, is assembled.Alongside with its advantage on the fast execution, the Frameup system allows to efficiently increase or decrease the number of the floors and consequently its exchangeability with other buildings of same nature. Thus, assuming a net of FRAMEUP buildings at each university, its exchangeability system would create the necessary conditions so that the number of floors at each campus would follow the fluctuations of the students’ population among the different universities on different periods of time, so to suppress the needs for housing or to avoid the surplus on construction.
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- Andrade, Pedro, et al.
(författare)
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On global and local buckling response of structural angle sandwich panels
- 2022
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Ingår i: Thin-walled structures. - : Elsevier. - 0263-8231 .- 1879-3223. ; 180
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Tidskriftsartikel (refereegranskat)abstract
- Having in mind the topic of industrialised construction and the benefits of modular construction, sandwich panels are investigated to be utilised as load-bearing wall elements. To assess its full potential, the present paper tackles the linear elastic buckling response of axially loaded angle sandwich panels, by means of numerical and analytical calculations, as the upper bound of its load bearing capacity. The failures modes are obtained and framed for concentrically loaded angle panels with fixed and pin-ended supports. A parametric study of the angle panel comprising a series of finite element models is undertaken where responses are compared with analytical calculations based on the theory of sandwich panels. Boundaries for local and global buckling are identified and framed.
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| 8. |
- Andrade, Pedro, et al.
(författare)
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Structural assessment of a column splice with opened slotted holes : Finger Connection
- 2017
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Ingår i: ce/papers. - : Ernst & Sohn Verlag. - 2509-7075. ; 1:2-3, s. 514-521
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Tidskriftsartikel (refereegranskat)abstract
- This paper introduces a novel joint based on a friction connection designed for column-splices. The jointwas developed within the scope of modular construction to improve the fast assembly of prefabricatedframes and to accommodate eventual misalignments. Gaps at the connection are considered on the jointhorizontal and vertical axis to accommodate misalignments whether they are rotations and/ordisplacements and so to allow for the easy fit of the columns. The efficiency of the joint resistance basedon different connection gaps subjected to uniform compression is assessed.
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| 9. |
- Bretman, Amanda, et al.
(författare)
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Systematic approaches to assessing high-temperature limits to fertility in animals
- 2024
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Ingår i: Journal of Evolutionary Biology. - 1010-061X .- 1420-9101.
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Tidskriftsartikel (refereegranskat)abstract
- Critical thermal limits (CTLs) gauge the physiological impact of temperature on survival or critical biological function, aiding predictions of species range shifts and climatic resilience. Two recent Drosophila species studies, using similar approaches to determine temperatures that induce sterility (thermal fertility limits [TFLs]), reveal that TFLs are often lower than CTLs and that TFLs better predict both current species distributions and extinction probability. Moreover, many studies show fertility is more sensitive at less extreme temperatures than survival (thermal sensitivity of fertility [TSF]). These results present a more pessimistic outlook on the consequences of climate change. However, unlike CTLs, TFL data are limited to Drosophila, and variability in TSF methods poses challenges in predicting species responses to increasing temperature. To address these data and methodological gaps, we propose 3 standardized approaches for assessing thermal impacts on fertility. We focus on adult obligate sexual terrestrial invertebrates but also provide modifications for other animal groups and life-history stages. We first outline a gold-standard protocol for determining TFLs, focussing on the effects of short-term heat shocks and simulating more frequent extreme heat events predicted by climate models. As this approach may be difficult to apply to some organisms, we then provide a standardized TSF protocol. Finally, we provide a framework to quantify fertility loss in response to extreme heat events in nature, given the limitations in laboratory approaches. Applying these standardized approaches across many taxa, similar to CTLs, will allow robust tests of the impact of fertility loss on species responses to increasing temperatures. Graphical AbstractOverview of the systematic methods (A, C, and D) to simultaneously assay lethal limits and thermal fertility limits or (B and E) thermal sensitivity of fertility. These are most easily applied to laboratory settings but can be used for assessing the fertility of wild-caught animals that have been exposed to natural temperatures.
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- Dougherty, Liam R., et al.
(författare)
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A systematic map of studies testing the relationship between temperature and animal reproduction
- 2024
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Ingår i: Ecological Solutions and Evidence. - : John Wiley & Sons. - 2688-8319. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- Exposure to extreme temperatures can negatively affect animal reproduction, by disrupting the ability of individuals to produce any offspring (fertility), or the number of offspring produced by fertile individuals (fecundity). This has important ecological consequences, because reproduction is the ultimate measure of population fitness: a reduction in reproductive output lowers the population growth rate and increases the extinction risk. Despite this importance, there have been no large-scale summaries of the evidence for effect of temperature on reproduction.We provide a systematic map of studies testing the relationship between temperature and animal reproduction. We systematically searched for published studies that statistically test for a direct link between temperature and animal reproduction, in terms of fertility, fecundity or indirect measures of reproductive potential (gamete and gonad traits).Overall, we collated a large and rich evidence base, with 1654 papers that met our inclusion criteria, encompassing 1191 species.The map revealed several important research gaps. Insects made up almost half of the dataset, but reptiles and amphibians were uncommon, as were non-arthropod invertebrates. Fecundity was the most common reproductive trait examined, and relatively few studies measured fertility. It was uncommon for experimental studies to test exposure of different life stages, exposure to short-term heat or cold shock, exposure to temperature fluctuations, or to independently assess male and female effects. Studies were most often published in journals focusing on entomology and pest control, ecology and evolution, aquaculture and fisheries science, and marine biology. Finally, while individuals were sampled from every continent, there was a strong sampling bias towards mid-latitudes in the Northern Hemisphere, such that the tropics and polar regions are less well sampled.This map reveals a rich literature of studies testing the relationship between temperature and animal reproduction, but also uncovers substantial missing treatment of taxa, traits, and thermal regimes. This database will provide a valuable resource for future quantitative meta-analyses, and direct future studies aiming to fill identified gaps.
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