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- Castellá, Bruno Femenía, et al.
(författare)
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Commissioning and first light results of an L’-band vortex coronagraph with the Keck II adaptive optics NIRC2 science instrument
- 2016
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Ingår i: Adaptive Optics Systems V. - : SPIE - International Society for Optical Engineering.
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Konferensbidrag (refereegranskat)abstract
- On March 2015 an L'-band vortex coronagraph based on an Annular Groove Phase Mask made up of a diamond sub-wavelength grating was installed on NIRC2 as a demonstration project. This vortex coronagraph operates in the L' band not only in order to take advantage from the favorable star/planet contrast ratio when observing beyond the K band, but also to exploit the fact that the Keck II Adaptive Optics (AO) system delivers nearly extreme adaptive optics image quality (Strehl ratios values near 90%) at 3.7 mu m. We describe the hardware installation of the vortex phase mask during a routine NIRC2 service mission. The success of the project depends on extensive software development which has allowed the achievement of exquisite real-time pointing control as well as further contrast improvements by using speckle nulling to mitigate the effect of static speckles. First light of the new coronagraphic mode was on June 2015 with already very good initial results. Subsequent commissioning nights were interlaced with science nights by members of the VORTEX team with their respective scientific programs. The new capability and excellent results so far have motivated the VORTEX team and the Keck Science Steering Committee (KSSC) to offer the new mode in shared risk mode for 2016B.
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| 2. |
- Nicolas, Aude, et al.
(författare)
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Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
- 2018
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Ingår i: Neuron. - : Cell Press. - 0896-6273 .- 1097-4199. ; 97:6, s. 1268-1283.e6
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Tidskriftsartikel (refereegranskat)abstract
- To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.
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| 3. |
- Swahnberg, Katarina, et al.
(författare)
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Men’s experiences of emotional, physical and sexual violence and abuse, and abuse in health care : a cross-sectional study of a Swedish random male population sample
- 2012
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Ingår i: Scandinavian Journal of Public Health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 40:2, s. 191-202
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Tidskriftsartikel (refereegranskat)abstract
- Aims: This article addresses the under-researched area of men's experiences of abuse. The aims were to estimate prevalence of emotional, physical, and sexual abuse and abuse in health care in a random sample of Swedish adult men, to compare these estimates with previously collected prevalence rates in a male clinical sample to see if prevalence rates were dependant on response rate and sampling method. We also wanted to contribute to a more general analysis of men's experiences of victimisation.Methods: Cross-sectional study design. The NorVold Abuse Questionnaire that measures the prevalence of four kinds of abuse was sent to 6000 men selected at random from the population of Astergötland, Sweden.Results: The response rate was 50% (n = 2924). Lifetime experiences of emotional abuse were reported by 16.7%, physical abuse by 48.9%, sexual abuse by 4.5%, and abuse in health care by 7.3%. The proportion of men who currently suffered from abusive experiences was highest for emotional abuse and abuse in health care. No difference in prevalence was seen between the random population sample and the clinical sample despite significant differences regarding response rate and background characteristics.Conclusions: Abuse against men is prevalent and men are victimised as patients in health care. Response rate and sampling method did not influence prevalence rates of abuse. Men's victimisation from emotional abuse and abuse in health care was associated with low income and being born outside of the Nordic countries and hence needs to be analysed in the intersections of gender, class, and ethnicity.
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