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| 2. |
- Adolfsson, Dan E., 1989-, et al.
(författare)
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Enhanement of amyloid fibril binding by ring expansion of thiazolino fused 2-pyridone peptidomimetics
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Thiazolino fused 2-pyridones undergo thiazoline ring opening by reaction with 2-nitrobenzyl bromide through thi- oether attack, and base promoted fragmentation of the resulting sulfonium ions. Subsequent deprotonation of the benzylic carbon and intramolecular 1,4-addition leads to ring closure, generating dihydrothiazine fused 2-pyridones by net ring expansion of the thiazoline ring. Application of the ring expansion procedure to the pyridine and pyrimidine fused thiazolino 2-pyridones provided compounds with enhanced fibril binding activity.
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| 3. |
- Adolfsson, Dan E., 1989-, et al.
(författare)
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Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β fibrils
- 2020
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 85:21, s. 14174-14189
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A BF3×OEt2 catalyzed intramolecular Povarov reaction was used to synthesize a library of 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with a range of O-alkylated salicylaldehydes and amino functionalized thiazolino-2-pyridones, to generate polyheterocycles with diverse substitution. The synthesized compounds were screened for their ability to bind α-synuclein and amyloid β fibrils in vitro. Analogs substituted with a nitro group bind to mature amyloid fibrils, and the activity moreover depends on the positioning of this functional group.
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| 5. |
- Bharate, Jaideep B., et al.
(författare)
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K2S2O8-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
- 2021
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Ingår i: Organic and biomolecular chemistry. - : The Royal Society of Chemistry. - 1477-0520 .- 1477-0539. ; 19:44, s. 9758-9772
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Tidskriftsartikel (refereegranskat)abstract
- We herein present the synthesis of diversely functionalized pyrimidine fused thiazolino-2-pyridones via K2S2O8-mediated oxidative coupling of 6-amino-7-(aminomethyl)-thiazolino-2-pyridones with aldehydes. The developed protocol is mild, has wide substrate scope, and does not require transition metal catalyst or base. Some of the synthesized compounds have an ability to inhibit the formation of Amyloid-β fibrils associated with Alzheimer's disease, while others bind to mature amyloid-β and α-synuclein fibrils.
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| 6. |
- Bhargava, Cherry, et al.
(författare)
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An intelligent model for residual life prediction of thyristor
- 2019
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Ingår i: International Journal of Engineering and Advanced Technology. - 2249-8958. ; 8:5, s. 1862-1866
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Tidskriftsartikel (refereegranskat)abstract
- Modern age is the age of integration, where millions of electronic components are integrated and installed on a single chip, to minimize the size of device and automatically increases the speed. But, as a greater number of components are placed on a single device, reliability becomes a concern issue, as failure of one component can degrade the complete device. From dimmer to high voltage power transmission, thyristors are widely used. The failure of thyristor can be proven dangerous for mankind, so the reliability prediction of thyristor is highly desirable. This paper is based on the accelerated life testing based experimental technique for reliability assessment. An intelligent model is designed using artificial intelligence techniques i.e. ANN, Fuzzy and ANFIS and comparative analysis is conducted to estimate the most accurate technique. Fuzzy based Graphical User Interface (GUI) is framed which informs the user about the live status of thyristor under various environmental conditions. The intelligent techniques are validated using experimental technique. An error analysis is conducted to predict the most accurate and reliable system for residual life prediction of thyristor. Out of all prediction techniques, ANFIS has the highest accuracy i.e. 95.3%, whereas ANN and Fuzzy inference system has accuracy range 86.1% and 89.2% respectively.
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| 7. |
- Cairns, Andrew G., et al.
(författare)
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An efficient and scalable synthesis of thiazolo ring fused 2-pyridones using flow chemistry
- 2021
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Ingår i: ARKIVOC. - : Arkat. - 1551-7004 .- 1551-7012. ; 2020:7, s. 365-378
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Tidskriftsartikel (refereegranskat)abstract
- Thiazolino ring fused 2-pyridones are a valuable scaffold with varied and substitution dependent biological activity, accessed primarily by an acyl ketene-imine cycloaddition and rearrangement. Although powerful, some aspects of this chemistry such as the requirement for excess starting material and the production of gas can make larger scale synthesis challenging. Here we describe the development, application and scaling of a continuous flow process allowing larger scale synthesis, with better handling of hazards and more reliable scaling. Optimisation and control of conditions allows for a more efficient synthesis, with a lower equivalence of the acyl ketene precursor required.
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| 8. |
- Gaba, Gurjot Singh, et al.
(författare)
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MAKE-IT—A Lightweight Mutual Authentication and Key Exchange Protocol for Industrial Internet of Things
- 2020
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 20:18, s. 1-21
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Tidskriftsartikel (refereegranskat)abstract
- Continuous development of the Industrial Internet of Things (IIoT) has opened up enormous opportunities for the engineers to enhance the efficiency of the machines. Despite the development, many industry administrators still fear to use Internet for operating their machines due to untrusted nature of the communication channel. The utilization of internet for managing industrial operations can be widespread adopted if the authentication of the entities are performed and trust is ensured. The traditional schemes with their inherent security issues and other complexities, cannot be directly deployed to resource constrained network devices. Therefore, we have proposed a strong mutual authentication and secret key exchange protocol to address the vulnerabilities of the existing schemes. We have used various cryptography operations such as hashing, ciphering, and so forth, for providing secure mutual authentication and secret key exchange between different entities to restrict unauthorized access. Performance and security analysis clearly demonstrates that the proposed work is energy efficient (computation and communication inexpensive) and more robust against the attacks in comparison to the traditional schemes
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| 9. |
- Khan, Suleman, et al.
(författare)
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AKAASH: A realizable authentication, key agreement, and secure handover approach for controller-pilot data link communications
- 2023
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Ingår i: International Journal of Critical Infrastructure Protection. - : ELSEVIER. - 1874-5482 .- 2212-2087. ; 42
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Tidskriftsartikel (refereegranskat)abstract
- Controller-Pilot Data Link Communications (CPDLC) are rapidly replacing voice-based Air Traffic Control (ATC) communications worldwide. Being digital, CPDLC is highly resilient and bandwidth efficient, which makes it the best choice for traffic-congested airports. Although CPDLC initially seems to be a perfect solution for modern-day ATC operations, it suffers from serious security issues. For instance, eavesdropping, spoofing, man-in-the-middle, message replay, impersonation attacks, etc. Cyber attacks on the aviation communication network could be hazardous, leading to fatal aircraft incidents and causing damage to individuals, service providers, and the aviation industry. Therefore, we propose a new security model called AKAASH, enabling several paramount security services, such as efficient and robust mutual authentication, key establishment, and a secure handover approach for the CPDLC-enabled aviation communication network. We implement the approach on hardware to examine the practicality of the proposed approach and verify its computational and communication efficiency and efficacy. We investigate the robustness of AKAASH through formal (proverif) and informal security analysis. The analysis reveals that the AKAASH adheres to the CPDLC standards and can easily integrate into the CPDLC framework.
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