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- Dahl, Anna K., 1975-, et al.
(författare)
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Overweight and obesity in old age are not associated with greater dementia risk
- 2008
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Ingår i: Journal of The American Geriatrics Society. - : John Wiley & Sons. - 0002-8614 .- 1532-5415. ; 56:12, s. 2261-2266
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To describe the association between body mass index (BMI) and dementia risk in older persons.DESIGN: Prospective population‐based study, with 8 years of follow‐up.SETTING: The municipality of Lieto, Finland, 1990/91 and 1998/99.PARTICIPANTS: Six hundred five men and women without dementia aged 65 to 92 at baseline (mean age 70.8).MEASUREMENTS: Weight and height were measured at baseline and at the 8‐year follow‐up. Dementia was clinically assessed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria.RESULTS: Eighty‐six persons were diagnosed with dementia. Cox regression analyses, adjusted for age, sex, education, cardiovascular diseases, smoking, and alcohol use, indicated that, for each unit increase in BMI score, the risk of dementia decreased 8% (hazard ratio (HR)=0.92, 95% confidence interval (CI)=0.87–0.97). This association remained significant when individuals who developed dementia early during the first 4 years of follow‐up were excluded from the analyses (HR=0.93, 95% CI=0.86–0.99). Women with high BMI scores had a lower dementia risk (HR=0.90, 95% CI=0.84–0.96). Men with high BMI scores also tended to have a lower dementia risk, although the association did not reach significance (HR=0.95, 95% CI=0.84–1.07).CONCLUSION: Older persons with higher BMI scores have less dementia risk than their counterparts with lower BMI scores. High BMI scores in late life should not necessarily be considered to be a risk factor for dementia.
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| 2. |
- Dahl, Anna, et al.
(författare)
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Overweight and dementia : a time-varying effect
- 2010
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Konferensbidrag (refereegranskat)abstract
- Objectives: The negative effects of overweight on cardiometabolic health is well-known. An increasing body of evidence extends the negative effects of midlife overweight to dementia. However, a different picture emerge when overweight is assessed in late life. The time-varying effect of weight status on dementia was evaluated in two prospective Nordic population-based studies. Methods: The participants included in the Swedish Twin Registry self-reported their height and weight in 1963 (mean age 52.5 years). About 25 years later these twins were either included in the SATSA study (50 years and older) or the OCTO-Twin study (80 years and older). Dementia was consequently screened for and diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria presently used at the time of diagnoses. The participants weight and height was assessed at baseline of the Finnish Lieto Study (mean age 70.8) and dementia was screened for and diagnosed according to the DSM-IV criteria eight years later. Results: Logistic regression analyses indicated that midlife overweight was associated with a greater risk of all cause dementia, odds ratio 1.55 (95% confidence interval (CI) = 1.18-2.04), when demographic and cardiometabolic risk factors and diseases were controlled for. However, Cox regression analyses indicated that for each unit increase in BMI score in late life, the risk of dementia decreased 8% (hazard ratio = 0.92, 95% CI = 0.87–0.97), when demographic and cardiometabolic risk factors and diseases were controlled for. The association remained significant when individuals who developed dementia during the first four years of follow-up were excluded from the analyses. Conclusions: Our results indicate there might be a time-varying effect of weight status on dementia. Preclinical dementia might blur the association between weight status and dementia in late life. This needs to be further analysed in studies following the same sample over the life course.
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