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- Kyle, RA, et al.
(författare)
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Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group
- 2003
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048. ; 121:5, s. 749-757
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Tidskriftsartikel (refereegranskat)abstract
- The monoclonal gammopathies are a group of disorders associated with monoclonal proliferation of plasma cells. The characterization of specific entities is an area of difficulty in clinical practice. The International Myeloma Working Group has reviewed the criteria for diagnosis and classification with the aim of producing simple, easily used definitions based on routinely available investigations. In monoclonal gammopathy of undetermined significance (MGUS) or monoclonal gammopathy, unattributed/unassociated (MG[u]), the monoclonal protein is < 30 g/l and the bone marrow clonal cells < 10% with no evidence of multiple myeloma, other B-cell proliferative disorders or amyloidosis. In asymptomatic (smouldering) myeloma the M-protein is greater than or equal to 30 g/l and/or bone marrow clonal cells greater than or equal to 10% but no related organ or tissue impairment (ROTI)(end-organ damage), which is typically manifested by increased calcium, renal insufficiency, anaemia, or bone lesions (CRAB) attributed to the plasma cell proliferative process. Symptomatic myeloma requires evidence of ROTI. Non-secretory myeloma is characterized by the absence of an M-protein in the serum and urine, bone marrow plasmacytosis and ROTI. Solitary plasmacytoma of bone, extramedullary plasmacytoma and multiple solitary plasmacytomas (+/- recurrent) are also defined as distinct entities. The use of these criteria will facilitate comparison of therapeutic trial data. Evaluation of currently available prognostic factors may allow better definition of prognosis in multiple myeloma.
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- Mukesh Kumar, Awasthi, et al.
(författare)
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A critical review on the development stage of biorefinery systems towards the management of apple processing-derived waste
- 2021
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Ingår i: Renewable & sustainable energy reviews. - : Elsevier. - 1364-0321 .- 1879-0690. ; 143
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Tidskriftsartikel (refereegranskat)abstract
- Apple is among the most consumed fruits in the world and the expansion of their processing is increasing the generation of waste such as apple pomace. It finds some applications in food and feed systems, anaerobic digestion, and composting; however it most ends in landfills or in informal disposal. Therefore, waste management strategies that address this waste accumulation need to be explored. This review provides a state-of-art of valorization strategies adopted for recovery of value added products from apple processing-derived waste and discusses on their development stage. The research community has laid most of its efforts on incorporation of apple pomace into feed and food systems and in the development of pectin- and phenolics-extraction methods. Incorporation of apple pomace in feed and food systems is still negligible due to its low protein and high fiber contents. Therefore, coupling apple pomace with microbial conversion for nutritional upgrade could change this scenario. Some environmentally-friendly techniques have been developed for extraction of pectin and phenolics, but major developments are needed on their integration to attain tailored extraction of several compounds. Recovery of value added routes of apple pomace towards production of bio-chemicals are characterized by lack of deep research studies and of a holistic approach. Integrated approach with techno-economic analysis, life-cycle assessment, and inter-sectorial initiatives will possibly reveal the most promising valorization routes.
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