| 1. |
- Lind, Lars, et al.
(författare)
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Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)
- 2021
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Ingår i: eLife. - : eLife Sciences Publications Ltd. - 2050-084X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
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| 2. |
- Bixby, H., et al.
(författare)
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Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- 2019
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 569:7755, s. 260-4
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Tidskriftsartikel (refereegranskat)abstract
- Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
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| 3. |
- Mishra, A, et al.
(författare)
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Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
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Tidskriftsartikel (refereegranskat)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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| 7. |
- Karlsson, Reine, et al.
(författare)
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Flervetenskaplig ljusforskning
- 2011
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Rapport (populärvet., debatt m.m.)abstract
- Den här skriften handlar om ljus och ljusets betydelse för oss människor. Tolv forskare med vitt skilda bakgrunder samlas och diskuterar frågor som skrider över gränserna. Vad är ljus egentligen? Hur kan vi förstå ljus? Hur påverkar det oss? På vilket sätt kan vi använda oss av det? Vilka tekniska möjligheter har vi att skapa och styra olika sorters ljus? Vilka möjligheter ger det oss inför framtiden? I centrum för dialogen står samarbete och nytänkande. Här ges en inblick i perspektiv på ljus från områden som biologi, teknik, material, fysik, estetik, filosofi, medicin och psykologi, vilka sammantaget, på ett åskådligt och lättbegripligt sätt, presenterar den flervetenskapliga ljusrelaterade kompetensen i Lund. Gruppen av experter hoppas att de frågor som ställs och de svar som ges i den här skriften ska inspirera och leda vidare inom fältet ljusforskning. Tillsammans med Pufendorfinstitutet, genom vilket expertgruppens initiativ getts möjlighet att växa och utvecklas, vill de med andra ord att sätta ljuset på...just ”ljuset”!
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| 8. |
- Parker, Victoria E. R., et al.
(författare)
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Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes
- 2023
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Ingår i: Nature Metabolism. - : NATURE PORTFOLIO. - 2522-5812. ; 5, s. 2086-2093
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Tidskriftsartikel (refereegranskat)abstract
- Cotadutide is a dual glucagon-like peptide 1 and glucagon receptor agonist under development for the treatment of non-alcoholic steatohepatitis and type 2 diabetes mellitus (T2DM) and chronic kidney disease. Non-alcoholic steatohepatitis is a complex disease with no approved pharmacotherapies, arising from an underlying state of systemic metabolic dysfunction in association with T2DM and obesity. Cotadutide has been shown to improve glycaemic control, body weight, lipids, liver fat, inflammation and fibrosis. We conducted a two-part, randomized phase 2a trial in men and women with overweight or obesity diagnosed with T2DM to evaluate the efficacy and safety of cotadutide compared with placebo and liraglutide. The primary endpoints were change from baseline to day 28 of treatment in postprandial hepatic glycogen (part A) and to day 35 of treatment in fasting hepatic glycogen (part B) with cotadutide versus placebo. Secondary endpoints in part B were changes in fasting hepatic glycogen with cotadutide versus the mono glucagon-like peptide 1 receptor agonist, liraglutide, and change in hepatic fat fraction. The trial met its primary endpoint. We showed that cotadutide promotes greater reductions in liver glycogen and fat compared with placebo and liraglutide. Safety and tolerability findings with cotadutide were comparable to those of previous reports. Thus, this work provides evidence of additional benefits of cotadutide that could be attributed to glucagon receptor engagement. Our results suggest that cotadutide acts on the glucagon receptor in the human liver to promote glycogenolysis and improve the metabolic health of the liver. ClinicalTrials.gov registration: NCT03555994. In a two-part randomized phase 2a trial in men and women with overweight or obesity and type 2 diabetes mellitus, cotadutide promoted greater reductions in liver glycogen and fat than placebo and liraglutide.
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| 9. |
- Abbak, Ramazan A., et al.
(författare)
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A precise gravimetric geoid model in a mountainous area with scarce gravity data : a case study in central Turkey
- 2012
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Ingår i: Studia Geophysica et Geodaetica. - : Springer Science and Business Media LLC. - 0039-3169 .- 1573-1626. ; 56:4, s. 909-927
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Tidskriftsartikel (refereegranskat)abstract
- In mountainous regions with scarce gravity data, gravimetric geoid determination is a difficult task that needs special attention to obtain reliable results satisfying the demands, e.g., of engineering applications. The present study investigates a procedure for combining a suitable global geopotential model and available terrestrial data in order to obtain a precise regional geoid model for Konya Closed Basin (KCB). The KCB is located in the central part of Turkey, where a very limited amount of terrestrial gravity data is available. Various data sources, such as the Turkish digital elevation model with 3 '' x 3 '' resolution, a recently published satellite-only global geopotential model from the Gravity Recovery and Climate Experiment satellite (GRACE) and the ground gravity observations, are combined in the least-squares sense by the modified Stokes' formula. The new gravimetric geoid model is compared with Global Positioning System (GPS)/levelling at the control points, resulting in the Root Mean Square Error (RMS) differences of +/- 6.4 cm and 1.7 ppm in the absolute and relative senses, respectively. This regional geoid model appears to he more accurate than the Earth Gravitational Model 2008, which is the best global model over the target area, with the RMS differences of +/- 8.6 cm and 1.8 ppm in the absolute and relative senses, respectively. These results show that the accuracy of a regional gravimetric model can be augmented by the combination of a global geopotential model and local terrestrial data in mountainous areas even though the quality and resolution of the primary terrestrial data are not satisfactory to the geoid modelling procedure.
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| 10. |
- Abrehdary, Majid, et al.
(författare)
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Combined Moho parameters determination using CRUST1.0 and Vening Meinesz-Moritz model
- 2015
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Ingår i: Journal of Earth Science. - : Springer Science and Business Media LLC. - 1674-487X .- 1867-111X. ; 26:4, s. 607-616
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Tidskriftsartikel (refereegranskat)abstract
- According to Vening Meinesz-Moritz (VMM) global inverse isostatic problem, either the Moho density contrast (crust-mantle density contrast) or the Moho geometry can be estimated by solving a non-linear Fredholm integral equation of the first kind. Here solutions to the two Moho parameters are presented by combining the global geopotential model (GOCO-03S), topography (DTM2006) and a seismic crust model, the latter being the recent digital global crustal model (CRUST1.0) with a resolution of 1A(0)x1A(0). The numerical results show that the estimated Moho density contrast varies from 21 to 637 kg/m(3), with a global average of 321 kg/m(3), and the estimated Moho depth varies from 6 to 86 km with a global average of 24 km. Comparing the Moho density contrasts estimated using our leastsquares method and those derived by the CRUST1.0, CRUST2.0, and PREM models shows that our estimate agrees fairly well with CRUST1.0 model and rather poor with other models. The estimated Moho depths by our least-squares method and the CRUST1.0 model agree to 4.8 km in RMS and with the GEMMA1.0 based model to 6.3 km.
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