| 1. |
- Blomstrand, Peter, et al.
(författare)
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Overweight and obesity impair left ventricular systolic function as measured by left ventricular ejection fraction and global longitudinal strain
- 2018
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Ingår i: Cardiovascular Diabetology. - : BioMed Central. - 1475-2840. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- AimsObesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim of the study was to explore the effects of overweight and obesity on left ventricular systolic function in patients with type 2 diabetes mellitus and a control group of non-diabetic persons.MethodsWe prospectively investigated 384 patients with type 2 diabetes mellitus, and 184 controls who participated in the CARDIPP and CAREFUL studies. The participants were grouped according to body mass index (normal weight < 25 kg/m2, overweight 25–29 kg/m2, and obesity ≥ 30 kg/m2). Echocardiography was performed at the beginning of the study and after 4-years in the patient group.ResultsUnivariable and multivariable regression analysis revealed that variations in left ventricular ejection fraction, global longitudinal strain, left ventricular mass and diastolic function expressed as E/é (the ratio between early diastolic mitral flow and annular motion velocities) all are related to body mass index. The mean and standard deviation of left ventricular ejection fraction and global longitudinal strain values were 57% (8%) vs. − 18.6% (2.3%) for normal weight patients, 53% (8%) vs. − 17.5% (2.3%) for overweight, and 49% (9%) vs. − 16.2% (3.0%) for obese (p < 0.05 vs. p < 0.05). Corresponding results in the control group were 58% (6%) vs. − 22.3% (3.0%), 55% (7%) vs. − 20.8% (3.1%) and 54% (8%) − 19.6% (4.0%) (p < 0.05 vs. p < 0.05). Patients who gained weight from baseline to follow-up changed left ventricular ejection fraction (median and interquartile range) by − 1.0 (9.0) % (n = 187) and patients who lost weight changed left ventricular ejection fraction by 1.0 (10.0) % (n = 179) (p < 0.05).ConclusionOverweight and obesity impair left ventricular ejection fraction and global longitudinal strain in both patients with type 2 diabetes mellitus and non-diabetic persons.
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| 2. |
- Glimelius, Bengt, et al.
(författare)
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U-CAN : a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
- 2018
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 57:2, s. 187-194
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Tidskriftsartikel (refereegranskat)abstract
- Background: Progress in cancer biomarker discovery is dependent on access to high-quality biological materials and high-resolution clinical data from the same cases. To overcome current limitations, a systematic prospective longitudinal sampling of multidisciplinary clinical data, blood and tissue from cancer patients was therefore initiated in 2010 by Uppsala and Umeå Universities and involving their corresponding University Hospitals, which are referral centers for one third of the Swedish population.Material and Methods: Patients with cancer of selected types who are treated at one of the participating hospitals are eligible for inclusion. The healthcare-integrated sampling scheme encompasses clinical data, questionnaires, blood, fresh frozen and formalin-fixed paraffin-embedded tissue specimens, diagnostic slides and radiology bioimaging data.Results: In this ongoing effort, 12,265 patients with brain tumors, breast cancers, colorectal cancers, gynecological cancers, hematological malignancies, lung cancers, neuroendocrine tumors or prostate cancers have been included until the end of 2016. From the 6914 patients included during the first five years, 98% were sampled for blood at diagnosis, 83% had paraffin-embedded and 58% had fresh frozen tissues collected. For Uppsala County, 55% of all cancer patients were included in the cohort.Conclusions: Close collaboration between participating hospitals and universities enabled prospective, longitudinal biobanking of blood and tissues and collection of multidisciplinary clinical data from cancer patients in the U-CAN cohort. Here, we summarize the first five years of operations, present U-CAN as a highly valuable cohort that will contribute to enhanced cancer research and describe the procedures to access samples and data.
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| 3. |
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| 4. |
- Agåker, Marcus, et al.
(författare)
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A five-axis parallel kinematic mirror unit for soft X-ray beamlines at MAX IV
- 2020
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Ingår i: Journal of Synchrotron Radiation. - : INT UNION CRYSTALLOGRAPHY. - 0909-0495 .- 1600-5775. ; 27, s. 262-271
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Tidskriftsartikel (refereegranskat)abstract
- With the introduction of the multi-bend achromats in the new fourth-generation storage rings the emittance has decreased by an order of magnitude resulting in increased brightness. However, the higher brightness comes with smaller beam sizes and narrower radiation cones. As a consequence, the requirements on mechanical stability regarding the beamline components increases. Here an innovative five-axis parallel kinematic mirror unit for use with soft X-ray beamlines using off-axis grazing-incidence optics is presented. Using simulations and measurements from the HIPPIE beamline at the MAX IV Laboratory it is shown that it has no Eigen frequencies below 90 Hz. Its positioning accuracy is better than 25 nm linearly and 17-35 mu rad angularly depending on the mirror chamber dimensions.
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| 5. |
- Agåker, Marcus, et al.
(författare)
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An ultra-high-stability four-axis ultra-high-vacuum sample manipulator
- 2021
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Ingår i: Journal of Synchrotron Radiation. - : International Union Of Crystallography. - 1600-5775 .- 0909-0495. ; 28:Pt 4, s. 1059-1068
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Tidskriftsartikel (refereegranskat)abstract
- A report on a four-axis ultra-high-stability manipulator developed for use at the Veritas and Species RIXS beamlines at MAX IV Laboratory, Lund, Sweden, is presented. The manipulator consists of a compact, light-weight X-Y table with a stiffened Z tower carrying a platform with a rotary seal to which a manipulator rod holding the sample can be attached. Its design parameters have been optimized to achieve high eigen-frequencies via a light-weight yet stiff construction, to absorb forces without deformations, provide a low center of gravity, and have a compact footprint without compromising access to the manipulator rod. The manipulator system can house a multitude of different, easily exchangeable, manipulator rods that can be tailor-made for specific experimental requirements without having to rebuild the entire sample positioning system. It is shown that the manipulator has its lowest eigen-frequency at 48.5 Hz and that long-term stability is in the few tens of nanometres. Position accuracy is shown to be better than 100 nm. Angular accuracy is in the 500 nrad range with a long-term stability of a few hundred nanoradians.
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| 6. |
- Bengtsson, Mattias
(författare)
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Att lämna en placering i samhällsvård : En studie om ungas övergång från samhällsvård till vuxenliv
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The focus in this thesis is young peoples’ (aged 17–20) experiences of leaving out-of-home care (OHC) and making the transition into adulthood. Prior research shows care leavers as a vulnerable group making the transition to adulthood at younger age, in shorter duration and with less support than their peers. The overarching aim is to gain knowledge of how young care leavers experience and handle their transition from OHC to adulthood, and how their experiences and strategies change over time. The study design is longitudinal with three waves of interviews: when still in care (T1), 6–11 months later when most of them had left care (T2) and another 10–19 months later (T3). Article I focuses the informants’ (n=15) expectations for their future and how these are changing over time (T1–T2). The participants’ short term expectations are characterized by worries (T1) and ambivalence (T2) – their long-term expectations are more optimistic (both T1 and T2) and tend to be guided by normative developmental patterns. The aim of article II is to study care leavers’ (n=20) strategies for handling adversities during their OHC transition. The results show that the participants over time (T1–T2) develop externally oriented strategies by navigating towards available resources, and internally oriented reflexive strategies for re-negotiating the meaning of their earlier experiences. Departing from an agency perspective article III focuses care leavers’ (n=14) transitional patterns of leaving care (T1–T3). Three patterns are identified: one stable long-term future oriented, one unstable short-term future oriented and one ambivalent pattern shuttling between long- and short-term future orientations. The aim in article IV is to study occupational trajectories, i.e. care leavers’ (n=14) paths into education and employment from a theoretical framework of agency vs. structure. The results show three ideal types of trajectories where agency is: (1) facilitated by structure, (2) perceived as free from structural constraints, and (3) hindered by structural constraints. The longitudinal design provides an original contribution the field of study by uncovering how care leavers’ expectations for their future is changing during the process of transition, how increasingly successful strategies are developed over time, and how transitional OHC patterns are influenced by the agents’ time horizons as well as by structural forces. A conclusion from the study is that societal support targeting young care leavers is deficient and needs to be developed and strengthened. Furthermore, the transition could be facilitated by extending the duration of the transition process, by including care leavers as active participating agents in the planning process of their passage out from OHC, and by strengthening the maintenance of care leavers’ relationships to supportive members in their formal and informal network. ”Independence” as the ultimate goal for young people leaving OHC is criticized based on the results showing that interdependent relationships to significant others is an integrated part of care leavers’ perception of adult life.
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| 7. |
- Bengtsson, Mattias, et al.
(författare)
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Teaming up or struggling alone from care to occupation – A study of young Swedish care leavers’ occupational trajectories
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Employment is crucial for independence and integration into society, but few studies have focused on care leavers’ own experiences of the transition to working life. This study presents longitudinal data on 14 young Swedish care leavers’ occupational trajectories from out-of-home care (OHC) towards working life. The first interview (T1) was conducted when the respondents were still in OHC but on the verge of leaving care, the second (T2) when the majority had left care, and the third (T3) when they had been out of care for some time. The aim was to study occupational trajectories from out-of-home care among young Swedish care leavers. What are the main features of their trajectories? How do they handle this transition? The thematic analysis generated three different occupational trajectories, recognized as “teamwork,” “lone wolf,” and “tug-of-war.” The theoretical concepts of structure and agency were used to understand these trajectories over time. “Agency enabled by structure” outlined the teamwork trajectory and seemed to imply a successful pathway towards working life. The lone wolf trajectory represented “agency perceived as free from structural constraint” and meant a successful “self-made” trajectory, however, at the expense of vulnerability, and the tug-of-war trajectory represented “agency hindered by structural constraint” as well as individual adversities.
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| 8. |
- Bengtsson, Mattias, et al.
(författare)
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Transitional patterns when leaving care – Care leavers’ agency in a longitudinal perspective
- 2020
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Ingår i: Children and youth services review. - : Elsevier. - 0190-7409 .- 1873-7765. ; 118
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Tidskriftsartikel (refereegranskat)abstract
- Based on three waves of semi-structured interviews, this longitudinal qualitative study aims to understand the transition from out-of-home care (OHC; foster care, residential care) to independent adulthood, for a group of Swedish care leavers aged 16–20 years (n = 14). What are the main patterns in their transition process? How is agency reflected in these processes? The first interview (T1) was conducted when they were all still in OHC but on the verge of leaving, the second (T2) when the majority had left care and the third (T3) when they had been out for some time. Average time from T1 to T3 was 21 months, ranging from 17 to 28 months. By directed content analysis and an abductive approach, three transitional patterns were identified: From care to societal insiders, From care to societal outsiders and From care to societal in-betweeners. These patterns were connected to different dimensions of agency. Agency with long-term goals was shown to be connected to a stable transition from care, facilitating the emerging identification as independent “insiders” of society. Agency oriented towards the short term instead seemed to be connected to unstable transitions with a growing perception of being left as “outsiders” of society. Shuttling between those agentic positions, trying to apply long-term agency but experiencing the need for instant and pragmatic decisions, implied a halted transition “in-between” OHC and independent adulthood.
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| 9. |
- Bengtsson, Mattias, et al.
(författare)
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‘Well, it’s up to me now’ – young care leavers’ strategies for handling adversities when leaving out-of-home care in Sweden
- 2018
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Ingår i: Nordic Social Work Research. - : Routledge. - 2156-857X .- 2156-8588. ; 8:sup 1
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Tidskriftsartikel (refereegranskat)abstract
- AbstractThis qualitative longitudinal study of 20 young Swedish care leavers investigates their subjective experience of and strategies for handling adversities when being in the process of leaving out-of-home care. The empirical data is based on two sets of interviews, the first conducted at time 1 (T1) when they were still in care but the moving out process had begun, the second (T2) 6-10 months later when the vast majority had left care. The thematic analysis based on resilience theory showed that the majority of the informants over time developed process-oriented strategies, which in our categorization emanated either from the inner world of the informants (e.g. through re-framing of experiences and an emerging self-reliance) or from their outer contextual world (e.g. through a restructuring of the social network). The results are discussed from a resilience theoretical perspective in which the informants' strategies are illustrated by the conceptual pair of 'navigation' and 'negotiation', used to make sense of their inner and outer world-oriented strategies.
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| 10. |
- Bengtsson, Mattias, et al.
(författare)
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Young care leavers’ expectations of their future : A question of time horizon
- 2018
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Ingår i: Child & Family Social Work. - : Wiley. - 1356-7500 .- 1365-2206. ; 23:2, s. 188-195
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Tidskriftsartikel (refereegranskat)abstract
- This paper investigates young care leavers’ expectations of their future after discharge from care. The results are based on qualitative longitudinal data where 16- to 21-year-old care leavers (n = 15) were interviewed twice, first when still in care but planning for their discharge (T1) and the second time 6–9 months later (T2). The analysis using a general inductive approach showed that their expectations were dependent on the time horizon and that there was an obvious difference between the young informants’ short- and long-term expectations. Their short-term expectations consisted of worries connected to their approaching discharge (at T1) and how to cope with challenges of everyday life after discharge from care (at T2). These results seem to echo negative outcomes shown in previous quantitative research. However, the informants’ long-term expectations provide a different picture, being mainly positive in both interviews (T1 and T2). The results are discussed from a life course perspective, where the informants’ visions of their future are framed and understood in terms of the different stages of their transition process.
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