| 1. |
- Ahlbeck Bergendahl, Ida, et al.
(författare)
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Fisk- och skaldjursbestånd i hav och sötvatten 2016 : Resursöversikt
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I rapporten kan du ta del av bedömningen som görs av situationen för bestånd som regleras inom ramen för EU:s gemensamma fiskeripolitik (GFP). Bedömningarna baseras på det forskningssamarbete och den rådgivning som sker inom det Internationella Havsforskningsrådet (ICES).De bestånd som förvaltas nationellt baseras på de biologiska underlagen, och rådgivningen i huvudsak på den forskning och övervakning samt analys som bedrivs av Institutionen för akvatiska resurser vid Sveriges lantbruksuniversitet (SLU Aqua) samt yrkesfiskets rapportering.Rapporten omfattar 41 fiskarter uppdelade i olika bestånd, samt sju skal- och blötdjursarter.Nytt för årets upplaga är kapitlet om ekosystemtjänster. Avsnittet beskriver de fördelar människan får genom ekosystemen, till exempel hur fisk och skaldjur kommer till nytta för människan genom föda, rekreation och biologisk mångfald. Nytt för i år är också att rapportens diagram och figurer anpassats för läsare med defekt färgseende.Översikten är utarbetad av SLU Aqua på uppdrag av Havs- och vattenmyndigheten.
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| 2. |
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| 3. |
- Andreas, Lale, et al.
(författare)
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Chemical and hydraulic conditions in a landfill/deposit for wood-based ash
- 2004
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Ingår i: The 3rd Intercontinental Landfill Research Symposium November 29th - December 2nd, 2004 in Toya, Hokkaido Japan. - Hokkaido : Center for Applied Ethics and Philosophy, Hokkaido University. ; , s. 121-129
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Aspengren, Sara, 1977, et al.
(författare)
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Rapport forskarenkät 2015
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Resultatet av den användarenkät som gjordes av Universitetsbiblioteket bland Göteborgs universitets disputerade forskare och doktorander 2014.
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| 5. |
- Bruzzese, Francesca, et al.
(författare)
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Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
- 2014
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Ingår i: Cancer Research. - : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 74:13, s. 3408-3417
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Tidskriftsartikel (refereegranskat)abstract
- The tumor stroma is vital to tumor development, progression, and metastasis. Cancer-associated fibroblasts (CAF) are among the abundant cell types in the tumor stroma, but the range of their contributions to cancer pathogenicity has yet to be fully understood. Here, we report a critical role for upregulation of the TGF beta/BMP family member GDF15 (MIC-1) in tumor stroma. GDF15 was found upregulated in situ and in primary cultures of CAF from prostate cancer. Ectopic expression of GDF15 in fibroblasts produced prominent paracrine effects on prostate cancer cell migration, invasion, and tumor growth. Notably, GDF15-expressing fibroblasts exerted systemic in vivo effects on the outgrowth of distant and otherwise indolent prostate cancer cells. Our findings identify tumor stromal cells as a novel source of GDF15 in human prostate cancer and illustrate a systemic mechanism of cancer progression driven by the tumor microenvironment. Further, they provide a functional basis to understand GDF15 as a biomarker of poor prognosis and a candidate therapeutic target in prostate cancer.
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| 6. |
- Davidsson, Cecilia, 1963-, et al.
(författare)
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Norrtullsligan : En dialog som fortsätter
- 2022
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Ingår i: Litteraturen i arbete. - : Trolltrumma. - 9789198632613 ; , s. 139-150
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Grundberg, Ida, et al.
(författare)
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In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics
- 2013
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 4:12, s. 2407-2418
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Tidskriftsartikel (refereegranskat)abstract
- Current assays for somatic mutation analysis are based on extracts from tissue sections that often contain morphologically heterogeneous neoplastic regions with variable contents of genetically normal stromal and inflammatory cells, obscuring the results of the assays. We have developed an RNA-based in situ mutation assay that targets oncogenic mutations in a multiplex fashion that resolves the heterogeneity of the tissue sample. Activating oncogenic mutations are targets for a new generation of cancer drugs. For anti-EGFR therapy prediction, we demonstrate reliable in situ detection of KRAS mutations in codon 12 and 13 in colon and lung cancers in three different types of routinely processed tissue materials. High-throughput screening of KRAS mutation status was successfully performed on a tissue microarray. Moreover, we show how the patterns of expressed mutated and wild-type alleles can be studied in situ in tumors with complex combinations of mutated EGFR, KRAS and TP53. This in situ method holds great promise as a tool to investigate the role of somatic mutations during tumor progression and for prediction of response to targeted therapy.
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| 8. |
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| 9. |
- Herrera, Mercedes, et al.
(författare)
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Prognostic Interactions between FAP plus Fibroblasts and CD8a+T Cells in Colon Cancer
- 2020
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 12:11
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Tidskriftsartikel (refereegranskat)abstract
- Simple Summary In addition to malignant cells, tumors are composed also of other cell types including immune cells and fibroblasts. These cell types interact with each other and with the malignant cells. Prognosis associations have previously been demonstrated for CD8-positive immune cells. Recent studies suggest that fibroblasts can affect the function of immune cells. The aim of this study was to investigate if the fibroblast composition of tumors affected the prognosis association of CD8 immune cells. This study demonstrated that in colon cancer, CD8 prognosis associations was restricted to the group of tumors with high expression the FAP fibroblast marker. Our findings suggest continued mechanistic studies regarding crosstalk between FAP-positive fibroblasts and the different immune cell types; and also support the investigation of fibroblast/T-cell interactions for therapeutic purposes. Inter-case variations in immune cell and fibroblast composition are associated with prognosis in solid tumors, including colon cancer. A series of experimental studies suggest immune-modulatory roles of marker-defined fibroblast populations, including FAP-positive fibroblasts. These studies imply that the fibroblast status of tumors might affect the prognostic significance of immune-related features. Analyses of a population-based colon cancer cohort demonstrated good prognosis associations of FAP intensity and CD8a density. Notably, a significant prognostic interaction was detected between these markers (p = 0.013 in nonadjusted analyses and p = 0.003 in analyses adjusted for cofounding factors) in a manner where the good prognosis association of CD8 density was restricted to the FAP intensity-high group. This prognostic interaction was also detected in an independent randomized trial-derived colon cancer cohort (p = 0.048 in nonadjusted analyses). In the CD8-high group, FAP intensity was significantly associated with a higher total tumor density of FoxP3-positive immune cells and a higher ratio of epithelial-to-stromal density of CD8a T cells. The study presents findings relevant for the ongoing efforts to improve the prognostic performance of CD8-related markers and should be followed by additional validation studies. Furthermore, findings support, in general, earlier model-derived studies implying fibroblast subsets as clinically relevant modulators of immune surveillance. Finally, the associations between FAP intensity and specific immune features suggest mechanisms of fibroblast-immune crosstalk with therapeutic potential.
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| 10. |
- Högdin, Sara, 1972-, et al.
(författare)
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Leaving home in early youth : Influential factors in running away from home or being thrown out
- 2012
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Ingår i: Nordic social work research. - Philadelphia, PA : Routledge. - 2156-8588 .- 2156-857X. ; 2:1, s. 39-58
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Tidskriftsartikel (refereegranskat)abstract
- The main objective of this article is to investigate the extent to which youth in Sweden run away from or are thrown out of their homes. A further aim is to determine what conditions lead up to and triggers such a break-up and to see what takes place during the break-up process itself. In our results roughly one in ten of youth in Sweden (≈11%) had experienced a difficult break-up from home by running away or being thrown out. Over 30% of those placed in foster families or institutions had run away from home or been thrown out. By our results, only a minority of runaways do so for the excitement or the fun. The majority made clear that their running away was a flight from the family rather than to something exciting and adventurous. It is also obvious from the results that young people who have run away three or more times are more severely at risk than those who have experienced only one or two break-ups from home. For some of these young people, a breakaway from home is the start, however premature, of an independent adult life. This vulnerable group of young people should be entitled to support from the social welfare system during their transition to adulthood.
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