| 1. |
- Andersson, Anders, et al.
(författare)
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The epidermal indeterminate cell- a special cell type?
- 1981
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Ingår i: Acta dermato-venereologica. Supplementum. - 0365-8341. ; 99, s. 41-48
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Tidskriftsartikel (refereegranskat)abstract
- Electron microscopy of normal human epidermiscomprising very large series of sections in combination withtilting of the sections has revealed that all "indeterminatecells" carry the specific markers of either melanocytes orLangerhans cells. The term "indeterminate cells" can thusbe abandoned. In addition, it is suggested that an epidermaldendritic cell lacking specific markers in the section underobservation can be characterized by the amount and distributionpattern of its microfilaments, an additional criterionbeing that the melanocytes carry a ciliunu
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| 2. |
- Axelsson, S, et al.
(författare)
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In vitro-uptake of L-Dopa and catecholamines into the epidermal Langerhans cell
- 1978
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Ingår i: Acta dermato-venereologica. Supplementum. - 0365-8341. ; 79, s. 31-35
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Tidskriftsartikel (refereegranskat)abstract
- The Langerhans cells are capable of taking up L-dopa and the catecholamines dopamine and noradrenaline when exposed to these substances in vitro. Within the cell L-dopa is found in the cytoplasm as well as in the nucleus, whereas the catecholamines are confined to cytoplasmic granules. The L-dopa uptake is most probably carrier-mediated and the hypothesis is brought forward that L-dopa enters the cell by exchange diffusion. At present little is known about the nature of the amine uptake mechanism.
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| 3. |
- Elofsson, Rolf, et al.
(författare)
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Evidence for endocytotic mechanisms in the epidermal Langerhans cells.
- 1981
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Ingår i: Acta dermato-venereologica. Supplementum. - 0365-8341. ; 99, s. 29-39
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Tidskriftsartikel (refereegranskat)abstract
- When the Langerhans cells (LC) are prepared forelectron microscopy with an osmotically balanced prefixative,they display their classical criteria, but in additionthey are provided with numerous microvilli and containpinocytotic vesicles. In cross-sections the specific discshapedgranules are visualized as rod-like profiles limited bya trilaminar membrane similar to the cell membrane. Inface-on projection the electron density of a single granule istoo low to permit its observation. It ts suggested that theracquet-shaped profile bounded by a non-trilaminar membrane,regarded as classical, is a fixation artifact. The viewis advanced that the Birbeck granules are formed by a processimplying a superimposition of membrane folds. Theoccurrence of phagocytosed melanosomes seems to be anormal phenomenon.The LC are highly activated in contact allergic dermatitis,as expressed by an increase in number, a polarizationof dendrites towards the surface and the appearance ofmembrane active zones characterized by intense membranefolding, combined with a formation of pinocytotic vesiclesand specific granules. Challenging sensitized skin withnickel leads to the occurrence of dark vesicles which probablylack a limiting membrane. It is concluded that the LCshow endocytotic activity and that they constitute animportant defense system in the epidermis, i.e., capable ofcapturing extracellular (endogenous or exogenous) materialvia different routes.
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| 4. |
- Elofsson, Rolf, et al.
(författare)
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The ciliated human keratinocyte
- 1983
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Ingår i: Journal of Ultrastructure Research. - 0022-5320. ; 87, s. 212-220
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Tidskriftsartikel (refereegranskat)abstract
- Human keratinocytes were investigated for the presence of single cilia. Almost all basal keratinocytes were found to carry a single cilium in normal, occluded, and psoriatic skin. The ciliary structure was progressively reduced in keratinocytes approaching the surface. No remnants of the ciliary apparatus were found in the granular layer. In one case of nickel-allergic dermatitis (patch test), the keratinocytes had lost their cilia; the significance of this surprising finding remains to be elucidated.
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