| 1. |
- Lestinsky, M., et al.
(author)
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Physics book: CRYRING@ESR
- 2016
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In: European Physical Journal: Special Topics. - : Springer Science and Business Media LLC. - 1951-6401 .- 1951-6355. ; 225:5, s. 797-882
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Research review (peer-reviewed)abstract
- The exploration of the unique properties of stored and cooled beams of highly-charged ions as provided by heavy-ion storage rings has opened novel and fascinating research opportunities in the realm of atomic and nuclear physics research. Since the late 1980s, pioneering work has been performed at the CRYRING at Stockholm (Abrahamsson et al. 1993) and at the Test Storage Ring (TSR) at Heidelberg (Baumann et al. 1988). For the heaviest ions in the highest charge-states, a real quantum jump was achieved in the early 1990s by the commissioning of the Experimental Storage Ring (ESR) at GSI Helmholtzzentrum für Schwerionenforschung (GSI) in Darmstadt (Franzke 1987) where challenging experiments on the electron dynamics in the strong field regime as well as nuclear physics studies on exotic nuclei and at the borderline to atomic physics were performed. Meanwhile also at Lanzhou a heavy-ion storage ring has been taken in operation, exploiting the unique research opportunities in particular for medium-heavy ions and exotic nuclei (Xia et al. 2002).
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| 3. |
- Vaziri-Sani, Fariba, et al.
(author)
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Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome
- 2006
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In: Kidney International. - : Nature Publishing Group. - 0085-2538 .- 1523-1755. ; 69:6, s. 981-988
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Journal article (peer-reviewed)abstract
- We investigated the phenotypic expression of factor H mutations in two patients with atypical hemolytic uremic syndrome (HUS). Factor H in serum was assayed by rocket immunoelectrophoresis, immunoblotting, and double immunodiffusion and in tissue by immunohistochemistry. Functional activity was analyzed by hemolysis of sheep erythrocytes and binding to endothelial cells. A homozygous mutation in complement control protein (CCP) domain 10 of factor H was identified in an adult man who first developed membranoproliferative glomerulonephritis and later HUS. C3 levels were very low. The patient had undetectable factor H levels in serum and a weak factor H 150 kDa band. Double immunodiffusion showed partial antigenic identity with factor H in normal serum owing to the presence of factor H-like protein 1. Strong specific labeling for factor H was detected in glomerular endothelium, mesangium and in glomerular and tubular epithelium as well as in bone marrow cells. A heterozygous mutation in CCP 20 of factor H was found in a girl with HUS. C3 levels were moderately decreased at onset. Factor H levels were normal and a normal 150 kDa band was present. Double immunodiffusion showed antigenic identity with normal factor H. Factor H labeling was minimal in the renal cortex. Factor H dysfunction was demonstrated by increased sheep erythrocyte hemolysis and decreased binding to endothelial cells. In summary, two different factor H mutations associated with HUS were examined: in one, factor H accumulated in cells, and in the other, membrane binding was reduced.
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| 4. |
- Andersson-Assarsson, Johanna C., 1974, et al.
(author)
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Evolution of age-related mutation-driven clonal haematopoiesis over 20 years is associated with metabolic dysfunction in obesity
- 2023
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In: Ebiomedicine. - 2352-3964. ; 92
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Journal article (peer-reviewed)abstract
- Background Haematopoietic clones caused by somatic mutations with >= 2% variant allele frequency (VAF) increase with age and are linked to risk of haematological malignancies and cardiovascular disease. Recent observations suggest that smaller clones (VAF<2%) are also associated with adverse outcomes. Our aims were to determine the prevalence of clonal haematopoiesis driven by clones of variable sizes in individuals with obesity treated by usual care or bariatric surgery (a treatment that improves metabolic status), and to examine the expansion of clones in relation to age and metabolic dysregulation over up to 20 years.Methods Clonal haematopoiesis-driver mutations (CHDMs) were identified in blood samples from participants of the Swedish Obese Subjects intervention study. Using an ultrasensitive assay, we analysed single-timepoint samples from 1050 individuals treated by usual care and 841 individuals who had undergone bariatric surgery, and multiple-timepoint samples taken over 20 years from a subset (n = 40) of the individuals treated by usual care.Findings In this explorative study, prevalence of CHDMs was similar in the single-timepoint usual care and bariatric surgery groups (20.6% and 22.5%, respectively, P = 0.330), with VAF ranging from 0.01% to 31.15%. Clone sizes increased with age in individuals with obesity, but not in those who underwent bariatric surgery. In the multiple-timepoint analysis, VAF increased by on average 7% (range -4% to 24%) per year and rate of clone growth was negatively associated with HDL-cholesterol (R = -0.68, 1.74 E-04).Interpretation Low HDL-C was associated with growth of haematopoietic clones in individuals with obesity treated by usual care.
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| 5. |
- Gorda, O., et al.
(author)
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Ion-optical design of CRYRING@ESR
- 2015
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In: Physica Scripta. - 0031-8949 .- 1402-4896. ; T166
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Journal article (peer-reviewed)abstract
- In 2012 the CRYRING storage ring was delivered from Stockholm to Darmstadt as a part of the Swedish in-kind contribution to the FAIR project. The ring lattice has been slightly changed for optimal injection and to provide additional space for experiment equipment. For the injection from the experimental storage ring (ESR), a new transfer line has been designed. The local injector line has been significantly modified compared to the previous one in Stockholm taking into account the geometry of the existing GSI building. In this paper we present the ion-optical properties of CRYRING@ESR after the described modifications. Single-turn injection from the ESR and multi-turn injection from the local injector are discussed. Ion-optical calculations of fast and slow extraction from CRYRING are also presented. The closed orbit correction scheme is considered taking into account the future arrangement of the beam position monitors and correction magnets. Based on the results of the calculations the requirements for the magnet alignment are finally discussed.
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| 6. |
- Kalogiannis, Konstantinos G., et al.
(author)
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Pyrolysis of lignin with 2DGC quantification of lignin oil : Effect of lignin type, process temperature and ZSM-5 in situ upgrading
- 2015
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In: Journal of Analytical and Applied Pyrolysis. - : Elsevier BV. - 0165-2370 .- 1873-250X. ; 115, s. 410-418
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Journal article (peer-reviewed)abstract
- Thermal and catalytic pyrolysis of various types of lignin and their influence on the yield and the quality of the produced lignin oil were studied. Lignins originated from a mixture of pine and spruce wood (softwood), a mixture of birch and aspen wood (hardwood) and Eucalyptus Urograndis. High degree of deoxygenation of the bio-oil and maximum yield of value-added chemicals were the main targets of this work. 2DGC-ToFMS analysis was used for the qualitative and quantitative characterization of the lignin oils. Softwood lignin was found to be the most attractive feedstock and high yields of a mixture of phenolic compounds were detected in all cases. High char production was also evident for all types of lignins accounting for almost 50% of the original feedstock. The use of a commercial ZSM-5 catalyst was extremely beneficial for the process, enhancing deoxygenation at higher oil yields compared to thermal pyrolysis. Depending on the nature of the lignin, guaiacyl or syringyl groups were dominant in the oils and it was found that process optimization, involving lignin, catalyst selection and temperature could significantly improve the process efficiency.
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| 9. |
- Nilsson, B, et al.
(author)
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Detection and characterization of immunoconglutinins in patients with systemic lupus erythematosus (SLE) : serial analysis in relation to disease course.
- 1992
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In: Clinical and Experimental Immunology. - 0009-9104 .- 1365-2249. ; 90:2, s. 251-255
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Journal article (peer-reviewed)abstract
- The levels of IgA, IgG and IgM immunoconglutinins (IK) were assessed in sera from 20 patients with SLE which were followed for 8-month periods. At the time of the exacerbation, IgG IKs were significantly increased to 226 +/- 90 arbitrary units (mean +/- s.e.m.) compared with both the minimum value of 75 +/- 28 in the SLE patients and with 31 +/- 2 in healthy controls (P < 0.05). There was no difference between SLE patients and controls in the levels of IgM and IgA IKs. Most of the SLE patients in this material showed maximal IgG IK levels before exacerbation, but there was no correlation between the clinical disease index and the levels of IgG IK. The specificity of IgG IKs showed a broad diversity for microtitre-fixed C3b, iC3b, C3c and C3dg. The antibodies were of IgG1, IgG3 and in two patients, IgG4 subclass. IgG IKs were correlated to the C3d/C3 ratio which suggested that the IK responses were secondary to C3 activation. In summary, unlike other conditions associated with complement activation where elevated IgM IKs are common, an increase in IgG IK levels was observed. It is possible that this diverging IK response contributes to the pathophysiology of the disease.
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