| 1. |
- Mishra, A, et al.
(author)
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Diminishing benefits of urban living for children and adolescents' growth and development
- 2023
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
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Journal article (peer-reviewed)abstract
- Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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| 2. |
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| 3. |
- Bonagas, Nadilly, et al.
(author)
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
- 2022
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In: NATURE CANCER. - : Springer Science and Business Media LLC. - 2662-1347. ; 3:2, s. 156-
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Journal article (peer-reviewed)abstract
- The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In the present study, we demonstrate a role for MTHFD2 in DNA replication and genomic stability in cancer cells, and perform a drug screen to identify potent and selective nanomolar MTHFD2 inhibitors; protein cocrystal structures demonstrated binding to the active site of MTHFD2 and target engagement. MTHFD2 inhibitors reduced replication fork speed and induced replication stress followed by S-phase arrest and apoptosis of acute myeloid leukemia cells in vitro and in vivo, with a therapeutic window spanning four orders of magnitude compared with nontumorigenic cells. Mechanistically, MTHFD2 inhibitors prevented thymidine production leading to misincorporation of uracil into DNA and replication stress. Overall, these results demonstrate a functional link between MTHFD2-dependent cancer metabolism and replication stress that can be exploited therapeutically with this new class of inhibitors. Helleday and colleagues describe a nanomolar MTHFD2 inhibitor that causes replication stress and DNA damage accumulation in cancer cells via thymidine depletion, demonstrating a potential therapeutic strategy in AML tumors in vivo.
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| 4. |
- Sjoberg, Lars E., et al.
(author)
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The zero gravity curve and surface and radii for geostationary and geosynchronous satellite orbits
- 2017
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In: Journal of Geodetic Science. - : De Gruyter Open. - 2081-9919 .- 2081-9943. ; 7:1, s. 43-50
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Journal article (peer-reviewed)abstract
- A geosynchronous satellite orbits the Earth along a constant longitude. A special case is the geostationary satellite that is located at a constant position above the equator. The ideal position of a geostationary satellite is at the level of zero gravity, i.e. at the geocentric radius where the gravitational force of the Earth equals the centrifugal force. These forces must be compensated for several perturbing forces, in particular for the lunisolar tides. Considering that the gravity field of the Earth varies not only radially but also laterally, this study focuses on the variations of zero gravity not only on the equator (for geostationary satellites) but also for various latitudes. It is found that the radius of a geostationary satellite deviates from its mean value of 42164.2 km only within +/- 2 m, mainly due to the spherical harmonic coefficient J(22), which is related with the equatorial flattening of the Earth. Away from the equator the zero gravity surface deviates from the ideal radius of a geosynchronous satellite, and more so for higher latitudes. While the radius of the former surface increases towards infinity towards the poles, the latter decreases about 520 m from the equator to the pole. Tidal effects vary these radii within +/- 2.3 km.
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| 5. |
- Abrehdary, Majid, 1983-, et al.
(author)
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Contribution of satellite altimetry in modelling Moho density contrast in oceanic areas
- 2019
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In: Journal of Applied Geodesy. - : WALTER DE GRUYTER GMBH. - 1862-9016 .- 1862-9024. ; 13:1, s. 33-40
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Journal article (peer-reviewed)abstract
- The determination of the oceanic Moho (or crust-mantle) density contrast derived from seismic acquisitions suffers from severe lack of data in large parts of the oceans, where have not yet been sufficiently covered by such data. In order to overcome this limitation, gravitational field models obtained by means of satellite altimetry missions can be proficiently exploited, as they provide global uniform information with a sufficient accuracy and resolution for such a task. In this article, we estimate a new Moho density contrast model named MDC2018, using the marine gravity field from satellite altimetry in combination with a seismic-based crustal model and Earth's topographic/bathymetric data. The solution is based on the theory leading to Vening Meinesz-Moritz's isostatic model. The study results in a high-accuracy Moho density contrast model with a resolution of 1° × 1° in oceanic areas. The numerical investigations show that the estimated density contrast ranges from 14.2 to 599.7 kg/m 3 with a global average of 293 kg/m 3 . In order to evaluate the accuracy of the MDC2018 model, the result was compared with some published global models, revealing that our altimetric model is able to image rather reliable information in most of the oceanic areas. However, the differences between this model and the published results are most notable along the coastal and polar zones, which are most likely due to that the quality and coverage of the satellite altimetry data are worsened in these regions.
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| 6. |
- Bagherbandi, Mohammad, et al.
(author)
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Comparison of crustal thickness from two gravimetric-isostatic models and CRUST2.0
- 2011
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In: Studia Geophysica et Geodaetica. - : Springer Science and Business Media LLC. - 0039-3169 .- 1573-1626. ; 55:4, s. 641-666
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Journal article (peer-reviewed)abstract
- The MohoroviiA double dagger discontinuity is the boundary between the Earth's crust and mantle. Several isostatic hypotheses exist for estimating the crustal thickness and density variation of the Earth's crust from gravity anomalies. The goal of this article is to compare the Airy-Heiskanen and Vening Meinesz-Moritz (VMM) gravimetric models for determining Moho depth, with the seismic Moho (CRUST2.0 or SM) model. Numerical comparisons are performed globally as well as for some geophysically interesting areas, such as Fennoscandia, Persia, Tibet, Canada and Chile. These areas are most complicated areas in view of rough topography (Tibet, Persia and Peru and Chile), post-glacial rebound (Fennoscandia and Canada) and tectonic activities (Persia). The mean Moho depth provided by CRUST2.0 is 22.9 +/- 0.1 km. Using a constant Moho density contrast of 0.6 g/cm(3), the corresponding mean values for Airy-Heiskanen and VVM isostatic models become 25.0 +/- 0.04 km and 21.6 +/- 0.08 km, respectively. By assuming density contrasts of 0.5 g/cm(2) and 0.35 g/cm(3) for continental and oceanic regions, respectively, the VMM model yields the mean Moho depth 22.6 +/- 0.1 km. For this model the global rms difference to CRUST2.0 is 7.2 km, while the corresponding difference between Airy-Heiskanen model and CRUST2.0 is 11 km. Also for regional studies, Moho depths were estimated by selecting different density contrasts. Therefore, one conclusion from the study is that the global compensation by the VMM method significantly improves the agreement with the CRUST2.0 vs. the local compensation model of Airy-Heiskanen. Also, the last model cannot be correct in regions with ocean depth larger than 9 km (e.g., outside Chile), as it may yield negative Moho depths. This problem does not occur with the VMM model. A second conclusion is that a realistic variation of density contrast between continental and oceanic areas yields a better fit of the VMM model to CRUST2.0. The study suggests that the VMM model can primarily be used to densify the CRUST2.0 Moho model in many regions based on separate data by taking advantage of dense gravity data. Finally we have found also that the gravimetric terrain correction affects the determination of the Moho depth by less than 2 km in mean values for test regions, approximately. Hence, for most practical applications of the VMM model the simple Bouguer gravity anomaly is sufficient.
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| 7. |
- Ericsson, Stefan, et al.
(author)
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Towards automatic detection of local bearing defects in rotating machines
- 2005
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In: Mechanical systems and signal processing. - : Elsevier BV. - 0888-3270 .- 1096-1216. ; 19:3, s. 509-535
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Journal article (peer-reviewed)abstract
- In this paper we derive and compare several different vibration analysis techniques for automatic detection of local defects in bearings. Based on a signal model and a discussion on to what extent a good bearing monitoring method should trust it, we present several analysis tools for bearing condition monitoring and conclude that wavelets are especially well suited for this task. Then we describe a large-scale evaluation of several different automatic bearing monitoring methods using 103 laboratory and industrial environment test signals for which the true condition of the bearing is known from visual inspection. We describe the four best performing methods in detail (two wavelet-based, and two based on envelope and periodisation techniques). In our basic implementation, without using historical data or adapting the methods to (roughly) known machine or signal parameters, the four best methods had 9-13% error rate and are all good candidates for further fine-tuning and optimisation. Especially for the wavelet-based methods, there are several potentially performance improving additions, which we finally summarise into a guiding list of suggestion.
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| 8. |
- Sjoberg, Lars E.
(author)
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On the geoid and orthometric height vs. quasigeoid and normal height
- 2018
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In: Journal of Geodetic Science. - : SCIENDO. - 2081-9919 .- 2081-9943. ; 8:1, s. 115-120
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Journal article (peer-reviewed)abstract
- The geoid, but not the quasigeoid, is an equipotential surface in the Earth's gravity field that can serve both as a geodetic datum and a reference surface in geophysics. It is also a natural zero-level surface, as it agrees with the undisturbed mean sea level. Orthometric heights are physical heights above the geoid, while normal heights are geometric heights (of the telluroid) above the reference ellipsoid. Normal heights and the quasigeoid can be determined without any information on the Earth's topographic density distribution, which is not the case for orthometric heights and geoid. We show from various derivations that the difference between the geoid and the quasigeoid heights, being of the order of 5 m, can be expressed by the simple Bouguer gravity anomaly as the only term that includes the topographic density distribution. This implies that recent formulas, including the refined Bouguer anomaly and a difference between topographic gravity potentials, do not necessarily improve the result. Intuitively one may assume that the quasigeoid, closely related with the Earth's surface, is rougher than the geoid. For numerical studies the topography is usually divided into blocks of mean elevations, excluding the problem with a non-star shaped Earth. In this case the smoothness of both types of geoid models are affected by the slope of the terrain, which shows that even at high resolutions with ultra-small blocks the geoid model is likely as rough as the quasigeoid model. In case of the real Earth there are areas where the quasigeoid, but not the geoid, is ambiguous, and this problem increases with the numerical resolution of the requested solution. These ambiguities affect also normal and orthometric heights. However, this problem can be solved by using the mean quasigeoid model defined by using average topographic heights at any requested resolution. An exact solution of the ambiguity for the normal height/quasigeoid can be provided by GNSS-levelling.
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| 9. |
- Sjoberg, Lars E., et al.
(author)
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Quasigeoid-to-geoid determination by EGM08
- 2012
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In: Earth Science Informatics. - : Springer Science and Business Media LLC. - 1865-0473 .- 1865-0481. ; 5:2, s. 87-91
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Journal article (peer-reviewed)abstract
- We present a method to estimate the difference between quasigeoid and geoid heights globally from the Earth Gravitational Model EGM08 and a related topographic model. The numerical computations with the standard topographic density of 2.67 g/cm(3) show that the maximum and minimum of the separations are estimated to 5.47 m and -0.11 m on the Tibet plateau and in the Indian Ocean, respectively. These estimates do not consider possible topographic density variations, which result in topographic bias changes proportional to the topographic elevation squared. Assuming such density changes of 10% from the standard value, the separation may change up to 5 dm.
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| 10. |
- Tenzer, Robert, et al.
(author)
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Global Isostatic Gravity Maps From Satellite Missions and Their Applications in the Lithospheric Structure Studies
- 2017
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In: IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1939-1404 .- 2151-1535. ; 10:2, s. 549-561
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Journal article (peer-reviewed)abstract
- Recent satellite gravity missions provide information on the Earth's gravity field with a global and homogenous coverage. These data have been utilized in geoscience studies to investigate the Earth's inner structure. In this study, we use the global gravitational models to compute and compare various isostatic gravity data. In particular, we compile global maps of the isostatic gravity disturbances by applying the Airy-Heiskanen and Pratt-Hayford isostatic theories based on assuming a local compensation mechanism. We further apply the Vening Meinesz-Moritz isostatic (flexural) model based on a more realistic assumption of the regional compensation mechanism described for the Earth's homogenous and variable crustal structure. The resulting isostatic gravity fields are used to analyze their spatial and spectral characteristics with respect to the global crustal geometry. Results reveal that each of the applied compensation model yields a distinctive spatial pattern of the isostatic gravity field with its own spectral characteristics. The Airy-Heiskanen isostatic gravity disturbances provide a very smooth gravity field with no correlation with the crustal geometry. The Pratt-Hayford isostatic gravity disturbances are spatially highly correlated with the topography on land, while the Vening-Meinesz Moritz isostatic gravity disturbances are correlated with the Moho geometry. The complete crust-stripped isostatic gravity disturbances reveal a gravitational signature of the mantle lithosphere. These general characteristics provide valuable information for selection of a particular isostatic scheme, which could be used for gravimetric interpretations, depending on a purpose of the study.
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