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- Cao, Danfeng, et al.
(författare)
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Tunable electroactive biomimetic bone-like surfaces for bone marrow-on-chips
- 2023
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Ingår i: 2023 IEEE BIOSENSORS CONFERENCE, BIOSENSORS. - : IEEE. - 9798350346046 - 9798350346114
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Konferensbidrag (refereegranskat)abstract
- Electro-stimulation is an effective way to manipulate the presentation of bio-factors at the materials interface. This study aimed to develop electrochemically-modified trabecular bone-like surfaces for manipulation of mesenchymal and hematopoietic cells. The electroactive surface was based on the conducting polymer polypyrrole for dynamic control of the presentation and mineralisation of chondrocyte-derived plasma membrane nanofragments (PMNFs) covalently immobilized on the surface. Electrochemical redox switching resulted in the PMNF-based formation of bone minerals with different morphologies, which further demonstrated to have distinct effects on the survival of mouse bone marrow-derived mesenchymal and hematopoietic cell populations cultured on the surface. This tunable electroactive surface could be a valuable tool for dynamically sensing and/or controlling stem cell functions in more suitable biomimetic microenvironments housing a stem cell niche.
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