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- Skarin, Angelika, et al.
(författare)
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Acanthamoeba keratitis in the south of Sweden
- 1996
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Ingår i: Acta Ophthalmologica Scandinavica. - 1395-3907. ; 74:6, s. 593-597
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Tidskriftsartikel (refereegranskat)abstract
- Eight patients with Acanthamoeba keratitis were diagnosed and treated at our clinic between February 1991 and February 1993. Five of these were contact lens wearers, two had suffered recent corneal trauma and one had recently undergone penetrating keratoplasty. The diagnoses were based on both culture and histological examination of biopsy material in three cases, on culture alone in two cases and on histological examination alone in three cases. In all but one primary treatment was Propamidine isethionate and Neomycin/Polymyxin B topically and Ketoconazole orally. Because of poor healing three patients additionally received Paromomycin and Miconazole or Clotrimazol topically; two of these were further treated with Polyhexamethylene biguanide topically. The interval from initial symptoms to accurate diagnoses varied from one to eleven months. In one patient the eye could not be saved; in the remaining patients visual acuity after healing ranged from hand movements to 1.0.
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- Skarin, Angelika, et al.
(författare)
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Long-term follow-up of patients with uveitis associated with juvenile idiopathic arthritis: a cohort study.
- 2009
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Ingår i: Ocular Immunology and Inflammation. - : Informa UK Limited. - 1744-5078 .- 0927-3948. ; 17:2, s. 104-108
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To analyze the clinical and visual outcome of 55 consecutive patients with juvenile idiopathic arthritis (JIA)-associated uveitis examined 7 and 24 years after the onset of the eye disease. METHODS: A retrospective study. RESULTS: Fifty-five out of 350 patients with JIA developed uveitis (15.7%). Forty-six (84%) of these had oligoarthritis, 6 (11%) had polyarthritis, and 3(5%) had systemic disease. Cataract was present in 42% at 7 years and in 51% at 24 years. Uveitic glaucoma was present in 5% at 7 years and in 22% at 24 years. After 24 years, 27 patients (49%) still had active uveitis. CONCLUSIONS: In half of these patients the uveitis was still active after 24 years of eye disease. In the group of patients with active disease, cataract and secondary glaucoma increased significantly between years 7 and 24 of disease.
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- Skarin, Angelika, et al.
(författare)
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Uveitis associated with juvenile arthritis : a continued cohort study 40 years after uveitis onset
- 2022
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Ingår i: Pediatric Rheumatology. - : Springer Science and Business Media LLC. - 1546-0096. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A third follow-up study, mean 40.7 years after uveitis onset, of a cohort originally consisting of 55 Swedish patients with uveitis associated with juvenile arthritis.METHOD: A retrospective study of the patients' ophthalmic medical records. The results were compared to those of the same cohort previously studied at mean 7.2 and 24.0 years after uveitis onset. In the present follow-up study, 30 of the original 55 patients consented to participate. Of these, 26 had ophthalmic medical records that were reviewed.RESULTS: In the 30 participants, active uveitis was seen in 43.4%, cataracts in 66.6% and glaucoma in 40.0%. When comparing data from previous follow-ups of the same cohort, a total of 61.8% were reported to have had cataracts at any of the three follow-ups, 29.0% had glaucoma or ocular hypertension and 12.7% had severe visual impairment in both eyes. At mean 40.7 years after uveitis onset 20% of patients in the original uveitis cohort were deceased. In 4 of the 11 deceased individuals, rheumatic disease was stated as the main cause of death, and in 3 it was considered a contributory factor in the patients deaths.CONCLUSIONS: Uveitis associated with juvenile arthritis can be active into midlife and possibly longer. Ocular complications and visual loss increased up to 40 years after uveitis diagnosis. The mortality rate of this cohort was higher than that of a corresponding Swedish population. Lifelong ophthalmic check-ups are probably necessary for patients diagnosed with this type of uveitis.
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