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- Fransson, Niklas, 1965, et al.
(författare)
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In search of the comfortable indoor environment: A comparison of the utility of objective and subjective indicators of indoor comfort.
- 2007
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Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323. ; 42:5, s. 1886-1890
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Tidskriftsartikel (refereegranskat)abstract
- Today, many procedures for assessing the indoor environment rely on both subjective and objective indicators (e.g. ANSI/ASHRAE 55-2004; ISO 10551). It is however unclear how these two types of measurements are related to perceived comfort. This article aims at assessing the relative utility of subjective (rating scale measures) and objective indicators of perceived comfort of indoor environments. In a hospital setting, physical environmental variables (e.g. temperature, relative humidity and noise level) were simultaneously measured as respondents (both patients and staff) rated their perception of the indoor environment. Regression analyses indicated that the subjective sensory ratings were significantly better than objective indicators at predicting overall rated indoor comfort. These results are discussed in relation to existing measurement procedures and standards.
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- Remnestål, Julia, et al.
(författare)
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Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds.
- 2021
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Ingår i: Alzheimer's research & therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer's disease (AD) is important for the understanding of disease pathophysiology and also crucial to be able to identify and validate disease biomarkers. While several biological changes that occur early in the disease development have already been recognized, the need for further characterization of the pathophysiological mechanisms behind AD still remains.In this study, we investigated cerebrospinal fluid (CSF) levels of 104 proteins in 307 asymptomatic 70-year-olds from the H70 Gothenburg Birth Cohort Studies using a multiplexed antibody- and bead-based technology.The protein levels were first correlated with the core AD CSF biomarker concentrations of total tau, phospho-tau and amyloid beta (Aβ42) in all individuals. Sixty-three proteins showed significant correlations to either total tau, phospho-tau or Aβ42. Thereafter, individuals were divided based on CSF Aβ42/Aβ40 ratio and Clinical Dementia Rating (CDR) score to determine if early changes in pathology and cognition had an effect on the correlations. We compared the associations of the analysed proteins with CSF markers between groups and found 33 proteins displaying significantly different associations for amyloid-positive individuals and amyloid-negative individuals, as defined by the CSF Aβ42/Aβ40 ratio. No differences in the associations could be seen for individuals divided by CDR score.We identified a series of transmembrane proteins, proteins associated with or anchored to the plasma membrane, and proteins involved in or connected to synaptic vesicle transport to be associated with CSF biomarkers of amyloid and tau pathology in AD. Further studies are needed to explore these proteins' role in AD pathophysiology.
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- Skoog, Jennie, 1978
(författare)
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Indoor Environment and User Perception. A Field Study in a Hospital Ward
- 2004
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The research on indoor environment has become more important and extensive the last decades. There is, however, a lack of studies made in buildings with two or more distinct groups of people. This study deals with hospital wards, which are a prime example of buildings occupied by more than one homogenous group of people.Many variables affect the human being when perceiving the indoor environment. The most common are physical environmental variables, physiological variables and behavioural variables. The physical environmental variables are relatively easy to measure. The difficulties are to translate the measured values into satisfactory indices. One way of doing this is, as in this study, to combine thermal measurements and indoor environment questionnaires. The thesis consists of a literature survey and two field studies. The outline of the survey is presented in the thesis and in Paper I. The field studies were performed in a Swedish hospital during both summer and winter conditions. Objective measurements and questionnaires were used simultaneously in order to get a clearer picture of how the two groups (staff and patients) perceive the indoor environment.The results show that this type of study is a suitable instrument to be used in hospital environment as well as in offices. The predicted optimal operative temperature for staff and patients differ according to their clothing and level of activity. Despite this, both staff and patients are satisfied with the thermal indoor climate. However, the perception of air humidity is as low in the summer study as in the winter study, even though the relative air humidity is considerably lower in the winter. Despite the similarities, staff and patients cannot be treated as, and assumed to be, one coherent group with same needs. This is mainly due to their different conditions (medicine, level of activity, clothing etc.)This study highlights the need to increase the demands on and recommendations for indoor environment in buildings with several distinct groups of users, such as hospital wards. The results of studies suggests that future recommendations and demands on indoor environment in hospital wards more clearly should recognise the differing needs of both staff and patients
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