| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Campieri, M, et al.
(författare)
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Oral budesonide is as effective as oral prednisolone in active Crohn's disease. The Global Budesonide Study Group
- 1997
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Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 41:2, s. 209-214
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Tidskriftsartikel (refereegranskat)abstract
- Background—The use of corticosteroids in active Crohn’s disease often becomes limited by side effects. Budesonide is a potent corticosteroid with low systemic bioavailability due to an extensive first pass liver metabolism.Aims—To compare the efficacy and safety of two dosage regimens of budesonide and prednisolone in patients with active Crohn’s disease affecting the ileum and/or the ascending colon.Patients and methods—One hundred and seventy eight patients were randomised to receive budesonide controlled ileal release (CIR) capsules 9 mg once daily or 4.5 mg twice daily, or prednisolone tablets 40 mg once daily. The treatment period was 12 weeks. The primary efficacy variable was clinical remission, defined as a Crohn’s Disease Activity Index (CDAI) of 150 or less.Results—After eight weeks of treatment, remission occurred in 60% of patients receiving budesonide once daily or prednisolone and in 42% of those receiving budesonide twice daily (p=0.062). The presence of glucocorticoid associated side effects was similar in all groups; however, moon face was more common in the prednisolone group (p=0.0005). The highest frequency of impaired adrenal function, as measured by a short ACTH test, was found in the prednisolone group (p=0.0023).Conclusions—Budesonide CIR, administered at 9 mg once daily or 4.5 mg twice daily, is comparable to prednisolone in inducing remission in active Crohn’s disease. The single dose administration is as promptly effective as prednisolone and represents a simpler and safer therapeutic approach, with a considerable reduction in side effects.
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| 3. |
- Gomez, Federico, et al.
(författare)
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Biochemical aspects of carrot processing
- 2003
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Ingår i: International Symposium on Future Technologies for Food Production and Future Food Scientists, Proceedings. - 0280-9737. ; :162, s. 87-87
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Konferensbidrag (refereegranskat)
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| 4. |
- Gomez, Federico, et al.
(författare)
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Influence of cold acclimation on the mechanical strength of carrot (Daucus carota L.) tissue
- 2004
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Ingår i: European Journal of Horticultural Science. - 1611-4434. ; 69:6, s. 229-234
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Tidskriftsartikel (refereegranskat)abstract
- We have investigated the influence of cold acclimation on the mechanical strength of carrot (Daucus carota L.) taproots. Changes in the mechanical strength were monitored when cold acclimation was induced in carrot plants cultivated in a growth chamber under strict climate control and in taproots harvested from field cultivation, where the plants had been exposed to the natural variations in climate. The appearance and accumulation of an antifreeze protein in the cell wall isolated from cold-stored taproots showed that a cold acclimation process is in progress in the harvested taproot derived from carrot plants grown in the field. The force needed to slice the taproots significantly increased during the first 12 weeks of storage, where the higher concentration of the antifreeze protein indicated the highest development of cold acclimation during that period of time. The increase in tissue rigidity during cold acclimation was also shown by the increase of the Young's modulus in taproot tissue from carrot plants acclimated 11 weeks under controlled temperature conditions. After 24 weeks of storage there was a significant increase in slicing force that was accompanied by signs of cell membrane deterioration, as measured by relative electrolyte leakage. Thus, the later increase in tissue strength might be related with a senescence process.
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| 5. |
- Gomez, Federico, et al.
(författare)
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On the induction of cold acclimation in carrots (Daucus carota L.) and its influence on storage performance
- 2005
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Ingår i: Food Research International. - : Elsevier BV. - 0963-9969. ; 38:1, s. 29-36
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the role of cold acclimation in carrot plants with respect to its influence on the storage performance of the harvested taproots. The induction of cold acclimation was followed in plants cultivated in a growth chamber under strict climate control and in taproots harvested from two separate field cultivations where the plants had been exposed to the natural variations in climate. Under controlled growth conditions, levels of antifreeze protein (AFP) mRNA were used as a marker for cold acclimation in carrot taproot tissue. Expression of this gene was induced by cold in discs excised from harvested taproots and this induction was clearly affected by the growth temperature of the plants from which the taproots were taken. These in vitro data were consistent with those from field-grown plants. In the cell wall of taproots harvested in year 2000, where the intact plants had frequently been exposed to temperatures below 6degreesC, a 36 kDa AFP accumulated to higher levels during storage than in the taproots harvested from plants grown in year 2001, where cultivation temperatures had rarely dropped below 6degreesC. The taproots from 2001 exhibited poor storage performance as shown by an earlier increase in relative electrolyte leakage and decrease in dry matter compared to taproots harvested in 2000. The capacity of the AFP to accumulate during storage was consistent with a high storage performance.
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| 6. |
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