| 1. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 2. |
- Bennert, Vardha N., et al.
(författare)
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A Local Baseline of the Black Hole Mass Scaling Relations for Active Galaxies. IV. Correlations Between M (BH) and Host Galaxy sigma, Stellar Mass, and Luminosity
- 2021
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Ingår i: Astrophysical Journal. - : IOP Publishing Ltd. - 0004-637X .- 1538-4357. ; 921:1
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Tidskriftsartikel (refereegranskat)abstract
- The tight correlations between the mass of supermassive black holes (M (BH)) and their host-galaxy properties have been of great interest to the astrophysical community, but a clear understanding of their origin and fundamental drivers still eludes us. The local relations for active galaxies are interesting in their own right and form the foundation for any evolutionary study over cosmic time. We present Hubble Space Telescope optical imaging of a sample of 66 local active galactic nuclei (AGNs); for 14 objects, we also obtained Gemini near-infrared images. We use state-of-the-art methods to perform surface photometry of the AGN host galaxies, decomposing them into spheroid, disk, and bar (when present), and inferring the luminosity and stellar mass of the components. We combine this information with spatially resolved kinematics obtained at the Keck Telescopes to study the correlations between M (BH) (determined from single-epoch virial estimators) and host galaxy properties. The correlations are uniformly tight for our AGN sample, with intrinsic scatter 0.2-0.4 dex, smaller than or equal to that of quiescent galaxies. We find no difference between pseudo and classical bulges or barred and nonbarred galaxies. We show that all the tight correlations can be simultaneously satisfied by AGN hosts in the 10(7)-10(9) M (circle dot) regime, with data of sufficient quality. The M (BH)-sigma relation is also in agreement with that of AGN with M (BH) obtained from reverberation mapping, providing an indirect validation of single-epoch virial estimators of M (BH).
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| 3. |
- Thomas, HS, et al.
(författare)
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- 2019
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