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| 2. |
- Broberg, Sarah, et al.
(författare)
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Potential för användning av lågtempererad värme för uppvärmning av växthus – industriell restvärme och värme från returen på fjärrvärme
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Inom projektet ”Innovativa energieffektiva växthus – designade för lågtempererade energikällor och värmeåtervinning”, som pågått mellan december 2020 – juni 2022 och finansierats av Energimyndigheten, föreslås och utvärderas ett nytt koncept för växthusodling, där energi- och odlingseffektivitet samspelar. Utvärderingen av konceptet inkluderar bland annat frågeställningar om hur energieffektiv teknik för växthus kan minska energibehovet vid odling och använda sig av värmeåtervinning och lågtempererade energikällor. Som en del av projektet genomförs och presenteras här en litteraturstudie över möjliga restvärmekällor i Sverige. Studien fokuserar i huvudsak på regionala kartläggningar som identifierats i svenska regioner. Dessa har identifierats och presenteras för tolv av Sveriges regioner. Möjligheterna att nyttja returvärmen på fjärrvärmevattnet diskuteras också, samt en diskussion om klimatavtryck från användning av restvärme.
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| 3. |
- Fahnestock, Jesse, 1974-, et al.
(författare)
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RISEnergy: Roadmaps for energy innovation in Sweden through 2030
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- RISE Research Institutes of Sweden is a group of research and technology organisations. RISE is a leading innovation partner working global cooperation with academia, enterprise and society to create value, growth and competitiveness through research excellence and innovation.In the area of Energy, RISE has developed innovation Roadmaps covering:Energy Efficient TransportElectric Power SystemEnergy Efficient and Smart BuildingsSustainable Thermal ProcessesEfficient Energy Use in IndustryDecarbonisation of Basic IndustriesThese Roadmaps describe development pathways for technologies, non-technical elements (market design, user behaviours, policies, etc.) and key actors that deliver on a plausible, desirable vision for each respective innovation area in 2030. These Roadmaps are intended to support RISE’s strategic planning and development, but should be relevant reading for anyone interested in energy innovation in Sweden.
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| 4. |
- Fernandes-Cerqueira, Catia, et al.
(författare)
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Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens
- 2015
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Ingår i: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6362 .- 1478-6354. ; 17
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: We have previously identified endogenously citrullinated peptides derived from fibrinogen in rheumatoid arthritis (RA) synovial tissues. In this study, we have investigated the auto-antigenicity of four of those citrullinated peptides, and explored their feasibility to target anti-citrullinated protein/peptide antibodies (ACPA). Methods: The autoantigenic potential of the fibrinogen peptides was investigated by screening 927 serum samples from the Epidemiological Investigation of RA (EIRA) cohort on a peptide microarray based on the ImmunoCAP ISAC (R) system. In order to assay for ACPA blocking, two independent pools of purified ACPA were incubated with the respective targeting peptide prior to binding to cyclic citrullinated peptide (CCP) 2 using the CCPlus (R) ELISA kit. Results: Two peptides derived from the fibrinogen a chain, Arg573Cit (563-583) and Arg591Cit (580-600), referred to as Cit573 and Cit591, and two peptides from the fibrinogen beta chain, Arg72Cit (62-81) and Arg74Cit (62-81) (Cit72 and Cit74), displayed 65 %, 15 %, 35 %, and 53 % of immune reactivity among CCP2-positive RA sera, respectively. In CCP2-negative RA sera, a positive reactivity was detected in 5 % (Cit573), 6 % (Cit591), 8 % (Cit72), and 4 % (Cit74). In the competition assay, Cit573 and Cit591 peptides reduced ACPA binding to CCP2 by a maximum of 84 % and 63 % respectively. An additive effect was observed when these peptides were combined. In contrast, Cit74 and Cit72 were less effective. Cyclization of the peptide structure containing Cit573 significantly increased the blocking efficiency. Conclusions: Here we demonstrate extensive autoantibody reactivity against in vivo citrullinated fibrinogen epitopes, and further show the potential use of these peptides for antagonizing ACPA.
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| 5. |
- Hrustic, Adnan, et al.
(författare)
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A simplified energy management system towards increased energy efficiency in SMEs
- 2011
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Ingår i: Proceedings of the World Renewable Energy Congress 2011 (WREC 2011), 9-13 May, Linköping. - : Linköping University Electronic Press. - 9789173930703 ; , s. 1513-1520
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Konferensbidrag (refereegranskat)abstract
- Swedish companies have since 2003 been able to get certified by an energy management system (EEMS) and companies that have been certified, can now show savings in energy use. The downside of today's EEMs is that too few small and medium-sized enterprises (SMEs) have chosen to certify such a system in the organization. To increase awareness and interest among SMEs, a simplified version of the EEMS would be desirable. This article presents a simplified EEMs for SMEs developed from the original European standard (SSEN 16 001). The article describes how the simple EEMS was developed and how the system was validated, i.e. how different companies responded to test-runs of the developed simplified EEMS. By testing the simplified EEMS in practice among various SMEs, different needs from the industry have been documented. The requests that were of greatest importance was how different incentives can be designed to increase the certification level, e.g. tax exemptions etc. The Swedish LTA for energy-intensive industries includes tax exemptions, as well as the certification of the European EEMS standard, and has shown to lead to large energy savings. An examples of a future energy policy could thus be a Long-Term Agreement (LTA)s program for SMEs including the simplified EEMS.
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| 7. |
- Larsson, Christer, et al.
(författare)
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Plant Plasma membrane
- 2007
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Ingår i: Encyclopedia of Life Sciences. - : Wiley.
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Forskningsöversikt (refereegranskat)abstract
- The plasma membrane encloses the cell contents and acts as a barrier between the cell and its environment. The plasma membrane allows a controlled exchange of ions and solutes with the rest of the organism and its surroundings, and plays an active role in many processes, such as plant development, pathogen resistance and frost-hardiness.
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| 9. |
- Larsson, Martin, et al.
(författare)
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Innovativa energieffektiva växthus - designade för lågtempererade energikällor och värmeåtervinning
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Lågtempererad restvärme är i dag en underutnyttjad resurs i samhället trots stor tillgång. I den här förstudien har växthus studerats, dvs system med stort behov av värmeenergi under delar av året. Projektet studerade teoretiskt ett växthuskoncept som använder lågvärdiga (30 – 40 °C) externa och interna värmekällor för uppvärmning, samt nyttjandet av frikyla (daggpunkt ca 25–10 °C) via termiskt lager för avfuktning. Syftet med förstudien är att skapa förutsättningar för hållbar och konkurrenskraftig växthusodling i Sverige genom synergier mellan olika branscher och tekniker. Som möjliggörare föreslås ett nytt koncept, som utvecklas för växthusodling, där energi- och odlingseffektivitet samspelar. Genom att utvärdera konceptet avser förstudien besvara frågeställningar om hur energieffektiv teknik dels kan minska energibehovet för växthus, dels använda sig av lågtempererade värmekällor, i kombination med värmeåtervinning, samtidigt som klimatet i växthuset styrs så odlingskapaciteten och CO2-gödsling förbättras. Resultatet visar att potentialen är mycket årstidsberoende och mycket beroende av hur stor värmekällan från växtbelysning är. Värmeåtervinning av växthusets interna värme kan minska värmeenergibehovet med ca 85% och växthuset kan använda lågtempererad värmekälla på ca 30–40 °C. Ytterligare resultat är att produktionen även kan ökas med ca 30–50% (beroende på årstid) med effektiv CO2-gödning och bättre klimat för växterna.
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| 10. |
- Ossipova, Elena, et al.
(författare)
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Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint
- 2014
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Ingår i: Arthritis Research & Therapy. - London : BioMed Central (BMC). - 1478-6362 .- 1478-6354. ; 16:4
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: A major subset of patients with rheumatoid arthritis (RA) is characterized by the presence of circulating autoantibodies directed to citrullinated proteins/peptides (ACPAs). These autoantibodies, which are commonly detected by using an enzyme-linked immunosorbent assay (ELISA) based on synthetic cyclic citrullinated peptides (CCPs), predict clinical onset and a destructive disease course. In the present study, we have used plasma and synovial fluids from patients with RA, for the affinity purification and characterization of anti-CCP2 reactive antibodies, with an aim to generate molecular tools that can be used in vitro and in vivo for future investigations into the pathobiology of the ACPA response. Specifically, this study aims to demonstrate that the surrogate marker CCP2 can capture ACPAs that bind to autoantigens expressed in vivo in the major inflammatory lesions of RA (that is, in the rheumatoid joint). METHODS: Plasma (n = 16) and synovial fluid (n = 26) samples were collected from RA patients with anti-CCP2 IgG levels of above 300 AU/mL. Total IgG was isolated on Protein G columns and subsequently applied to CCP2 affinity columns. Purified anti-CCP2 IgG was analyzed for reactivity and specificity by using the CCPlus(R) ELISA, in-house peptide ELISAs, Western blot, and immunohisto-/immunocytochemistry. RESULTS: Approximately 2% of the total IgG pool in both plasma and synovial fluid was CCP2-reactive. Purified anti-CCP2 reactive antibodies from different patients showed differences in binding to CCP2 and differences in binding to citrullinated peptides from alpha-enolase, vimentin, fibrinogen, and collagen type II, illustrating different ACPA fine-specificity profiles. Furthermore, the purified ACPA bound not only in vitro citrullinated proteins but, more importantly, in vivo-generated epitopes on synovial fluid cells and synovial tissues from patients with RA. CONCLUSIONS: We have isolated ACPAs from plasma and synovial fluid and demonstrated that the CCP2 peptides, frequently used in diagnostic ELISAs, de facto act as surrogate antigens for at least four different, well-characterized, largely non-cross-reactive, ACPA fine specificities. Moreover, we have determined the concentration and proportion of CCP2-reactive IgG molecules in rheumatoid plasma and synovial fluid, and we have shown that the purified ACPAs can be used to detect both in vitro- and in vivo-generated citrullinated epitopes by various techniques. We anticipate that these antibodies will provide us with new opportunities to investigate the potential pathogenic effects of human ACPAs. © 2014 Ossipova et al.; licensee BioMed Central Ltd.
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