| 1. |
- Cruz, Raquel, et al.
(författare)
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Novel genes and sex differences in COVID-19 severity
- 2022
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:22, s. 3789-3806
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Tidskriftsartikel (refereegranskat)abstract
- Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
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| 2. |
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| 3. |
- Algervik, Robert, 1981-
(författare)
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Embedding Theorems for Mixed Norm Spaces and Applications
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is devoted to the study of mixed norm spaces that arise in connection with embeddings of Sobolev and Besov type spaces. We study different structural, integrability, and smoothness properties of functions satisfying certain mixed norm conditions. Conditions of this type are determined by the behaviour of linear sections of functions. The work in this direction originates in a paper due to Gagliardo (1958), and was further developed by Fournier (1988), by Blei and Fournier (1989), and by Kolyada (2005). Here we continue these studies. We obtain some refinements of known embeddings for certain mixed norm spaces introduced by Gagliardo, and we study general properties of these spaces. In connection with these results, we consider a scale of intermediate mixed norm spaces, and prove intrinsic embeddings in this scale. We also consider more general, fully anisotropic, mixed norm spaces. Our main theorem states an embedding of these spaces to Lorentz spaces. Applying this result, we obtain sharp embedding theorems for anisotropic Sobolev-Besov spaces, and anisotropic fractional Sobolev spaces. The methods used are based on non-increasing rearrangements, and on estimates of sections of functions and sections of sets. We also study limiting relations between embeddings of spaces of different type. More exactly, mixed norm estimates enable us to get embedding constants with sharp asymptotic behaviour. This gives an extension of the results obtained for isotropic Besov spaces by Bourgain, Brezis, and Mironescu, and for anisotropic Besov spaces by Kolyada. We study also some basic properties (in particular the approximation properties) of special weak type spaces that play an important role in the construction of mixed norm spaces, and in the description of Sobolev type embeddings. In the last chapter, we study mixed norm spaces consisting of functions that have smooth sections. We prove embeddings of these spaces to Lorentz spaces. From this result, known properties of Sobolev-Liouville spaces follow.
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| 4. |
- Alves, Gustavo R., et al.
(författare)
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International Cooperation for Remote Laboratory Use
- 2018
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Ingår i: Contributions to Higher Engineering Education. - Singapore : Springer. - 9789811089176 ; , s. 1-31
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Bokkapitel (refereegranskat)abstract
- Experimenting is fundamental to the training process of all scientists and engineers. While experiments have been traditionally done inside laboratories, the emergence of Information and Communication Technologies added two alternatives accessible anytime, anywhere. These two alternatives are known as virtual and remote laboratories and are sometimes indistinguishably referred as online laboratories. Similarly to other instructional technologies, virtual and remote laboratories require some effort from teachers in integrating them into curricula, taking into consideration several factors that affect their adoption (i.e., cost) and their educational effectiveness (i.e., benefit). This chapter analyzes these two dimensions and sustains the case where only through international cooperation it is possible to serve the large number of teachers and students involved in engineering education. It presents an example in the area of electrical and electronics engineering, based on a remote laboratory named Virtual Instruments System in Reality, and it then describes how a number of European and Latin American institutions have been cooperating under the scope of an Erasmus+ project, for spreading its use in Brazil and Argentina.
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| 5. |
- Asekritova, Irina, et al.
(författare)
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Rearrangement estimates for A(infinity) weights
- 2019
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Ingår i: Revista Matemática Complutense. - : SPRINGER-VERLAG ITALIA SRL. - 1139-1138 .- 1988-2807. ; 32:3, s. 731-743
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Tidskriftsartikel (refereegranskat)abstract
- We find a new characterizations of an A(infinity) weight omega, in terms of the decreasing rearrangement of the restriction of omega to cubes Q.
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| 6. |
- Barza, Sorina, et al.
(författare)
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Mixed norm and multidimensional Lorentz spaces
- 2006
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Ingår i: Positivity (Dordrecht). - : Springer Science and Business Media LLC. - 1385-1292 .- 1572-9281. ; 10:3, s. 539-554
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Tidskriftsartikel (refereegranskat)abstract
- In the last decade, the problem of characterizing the normability of the weighted Lorentz spaces has been completely solved ([16], [7]). However, the question for multidimensional Lorentz spaces is still open. In this paper, we consider weights of product type, and give necessary and sufficient conditions for the Lorentz spaces, defined with respect to the two-dimensional decreasing rearrangement, to be normable. To this end, it is also useful to study the mixed norm Lorentz spaces. Finally, we prove embeddings between all the classical, multidimensional, and mixed norm Lorentz spaces.
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| 7. |
- Barza, Sorina, et al.
(författare)
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Multidimensional rearrangement and Lorentz spaces
- 2004
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Ingår i: Acta Mathematica Hungarica. - 0236-5294 .- 1588-2632. ; 104:3, s. 203-224
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Tidskriftsartikel (refereegranskat)abstract
- We define a multidimensional rearrangement, which is related to classical inequalities for functions that are monotone in each variable. We prove the main measure theoretical results of the new theory and characterize the functional properties of the associated weighted Lorentz spaces.
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| 8. |
- Barza, Sorina, Associate professor, 1967-, et al.
(författare)
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Optimal non-absolute domains for the Hardy operator minus identity
- 2024
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Ingår i: Journal of Mathematical Analysis and Applications. - : Elsevier. - 0022-247X .- 1096-0813. ; 538:1
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Tidskriftsartikel (refereegranskat)abstract
- We characterize the optimal non-absolute domain for the Hardy operator minus the identity, in the Lebesgue space Lp(0,∞), 1≤p≤∞. We also address a similar question for the dual Hardy operator minus the identity.
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| 9. |
- Barza, Sorina, 1967-, et al.
(författare)
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Sharp constants between equivalent norms in weighted Lorentz spaces
- 2010
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Ingår i: Journal of the Australian Mathematical Society. - Cambridge : Cambridge University Press. - 1446-7887 .- 1446-8107. ; 88:1, s. 19-27
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Tidskriftsartikel (refereegranskat)abstract
- For an increasing weight w in Bp (or equivalently in Ap), we find the best constants for the inequalities relating the standard norm in the weighted Lorentz space Λp(w) and the dual norm.
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