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- Adams, Vanessa M., et al.
(författare)
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Using Multiple Methods to Understand the Nature of Relationships in Social Networks
- 2018
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Ingår i: Society & Natural Resources. - : Informa UK Limited. - 0894-1920 .- 1521-0723. ; 31:7, s. 755-772
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Tidskriftsartikel (refereegranskat)abstract
- Effective natural resource management (NRM) often depends on collaboration through formal and informal relationships. Social network analysis (SNA) provides a framework for studying social relationships; however, a deeper understanding of the nature of these relationships is often missing. By integrating multiple analytical methods (including SNA, evidence ratings, and perception matrices), we were able to investigate the nature of relationships in NRM social networks across five service types (e.g., technical advice, on-ground support) in our case study region, Daly catchment Australia. Only one service type was rated as highly associated with free choice in establishing relationships: technical advice/knowledge. Beneficial characteristics of NRM organizations, such as collaborative and transparent, were associated with the presence of freely chosen relationships between organizations. Our results suggest a need to improve our understanding of organizational roles and characteristics, in particular for use in applied NRM contexts, such as network weaving or disseminating information.
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| 2. |
- Labbé, David P., et al.
(författare)
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TOP2A and EZH2 provide early detection of an aggressive prostate cancer subgroup
- 2017
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Ingår i: Clinical Cancer Research. - 1078-0432. ; 23:22, s. 7072-7083
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Current clinical parameters do not stratify indolent from aggressive prostate cancer. Aggressive prostate cancer, defined by the progression from localized disease to metastasis, is responsible for the majority of prostate cancer–associated mortality. Recent gene expression profiling has proven successful in predicting the outcome of prostate cancer patients; however, they have yet to provide targeted therapy approaches that could inhibit a patient's progression to metastatic disease. Experimental Design: We have interrogated a total of seven primary prostate cancer cohorts (n = 1,900), two metastatic castration-resistant prostate cancer datasets (n = 293), and one prospective cohort (n = 1,385) to assess the impact of TOP2A and EZH2 expression on prostate cancer cellular program and patient outcomes. We also performed IHC staining for TOP2A and EZH2 in a cohort of primary prostate cancer patients (n = 89) with known outcome. Finally, we explored the therapeutic potential of a combination therapy targeting both TOP2A and EZH2 using novel prostate cancer–derived murine cell lines. Results: We demonstrate by genome-wide analysis of independent primary and metastatic prostate cancer datasets that concurrent TOP2A and EZH2 mRNA and protein upregulation selected for a subgroup of primary and metastatic patients with more aggressive disease and notable overlap of genes involved in mitotic regulation. Importantly, TOP2A and EZH2 in prostate cancer cells act as key driving oncogenes, a fact highlighted by sensitivity to combination-targeted therapy. Conclusions: Overall, our data support further assessment of TOP2A and EZH2 as biomarkers for early identification of patients with increased metastatic potential that may benefit from adjuvant or neoadjuvant targeted therapy approaches.
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