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- Pagani, Alberto, et al.
(författare)
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An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin
- 2007
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Ingår i: Natural Product Communications. - 1934-578X. ; 2:6, s. 637-642
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Tidskriftsartikel (refereegranskat)abstract
- A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.
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