| 1. |
- Bullock, Adrian, et al.
(författare)
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Designing interactive collaborative environments
- 2001. - 2
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Ingår i: Collaborative Virtual Environments: Digital Places and Spaces for Interaction. - : Springer. - 1852332441
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- We describe our experiences of creating and using a wide variety of techniques and applications to support collaboration in virtual environments for different activities and user groups. Our aim is to offer plentiful and rich possibilities for interaction across and between both real and virtual environments.
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| 2. |
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| 3. |
- Cheng, Qing, et al.
(författare)
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Preclinical PET imaging of EGFR levels : pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake
- 2016
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Ingår i: EJNMMI Research. - : Springer. - 2191-219X. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Background: Though overexpression of epidermal growth factor receptor (EGFR) in several forms of cancer is considered to be an important prognostic biomarker related to poor prognosis, clear correlations between biomarker assays and patient management have been difficult to establish. Here, we utilize a targeting directly followed by a non-targeting tracer-based positron emission tomography (PET) method to examine some of the aspects of determining specific EGFR binding in tumors. Methods: The EGFR-binding Affibody molecule Z(EGFR:2377) and its size-matched non-binding control Z(Taq:3638) were recombinantly fused with a C-terminal selenocysteine-containing Sel-tag (Z(EGFR:2377)-ST and Z(Taq:3638)-ST). The proteins were site-specifically labeled with DyLight488 for flow cytometry and ex vivo tissue analyses or with C-11 for in vivo PET studies. Kinetic scans with the C-11-labeled proteins were performed in healthy mice and in mice bearing xenografts from human FaDu (squamous cell carcinoma) and A431 (epidermoid carcinoma) cell lines. Changes in tracer uptake in A431 xenografts over time were also monitored, followed by ex vivo proximity ligation assays (PLA) of EGFR expressions. Results: Flow cytometry and ex vivo tissue analyses confirmed EGFR targeting by ZE(GFR:2377)-ST-DyLight488. [Methyl-C-11]-labeled Z(EGFR:2377)-ST-CH3 and Z(Taq:3638)-ST-CH3 showed similar distributions in vivo, except for notably higher concentrations of the former in particularly the liver and the blood. [Methyl-C-11]-Z(EGFR:2377)-ST-CH3 successfully visualized FaDu and A431 xenografts with moderate and high EGFR expression levels, respectively. However, in FaDu tumors, the non-specific uptake was large and sometimes equally large, illustrating the importance of proper controls. In the A431 group observed longitudinally, non-specific uptake remained at same level over the observation period. Specific uptake increased with tumor size, but changes varied widely over time in individual tumors. Total (membranous and cytoplasmic) EGFR in excised sections increased with tumor growth. There was no positive correlation between total EGFR and specific tracer uptake, which, since Z(EGFR:2377) binds extracellularly and is slowly internalized, indicates a discordance between available membranous and total EGFR expression levels. Conclusions: Same-day in vivo dual tracer imaging enabled by the Sel-tag technology and C-11-labeling provides a method to non-invasively monitor membrane-localized EGFR as well as factors affecting non-specific uptake of the PET ligand.
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| 4. |
- Fahlén, Lennart, et al.
(författare)
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A space based model for user interaction in shared synthetic environments
- 1993. - 8
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In a distributed shared synthetic environment with provisions for high quality 3D visualization and interaction, it is possible to implement a powerful variant of a roomslspace metaphor based on the concept of presence or proximity between participants in 3D space. This kind of model can be used as an interface between the user and the computer, for overview and control of applications, tile systems, networks and other computer resources, as well as for communication and collaboration with other users in the networked environment. We model proximity with a geometric volume of the immediate surroundings, the aura, of the participant’s representation in the synthetic environment. This proximity, or aura, is used to establish presence at meetings, to establish communication channels and to provide interaction.
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| 5. |
- Fahlén, Lennart, et al.
(författare)
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The Pond: trawling the information sea
- 2001. - 2
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Ingår i: ERCIM News.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- The Pond is a desk-projection-based system for search, visualisation and transactions of data elements stored in local databases or on the Internet. Based on a 3D ecosystem metaphor, the Pond approach to querying, presenting and manipulating data elements differs considerably from more conventional information systems.
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| 6. |
- Frecon, Emmanuel, et al.
(författare)
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An overview of the COVEN platform
- 2001. - 3
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Ingår i: Presence - Teleoperators and Virtual Environments. - : MIT Press - Journals. - 1054-7460 .- 1531-3263. ; 10, s. 109-127
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Tidskriftsartikel (refereegranskat)abstract
- A central aim of the COVEN project was to prototype large-scale applications of collaborative virtual environments (CVEs) that went beyond the existing state of the art. These applications were used in a series of real-scale networked trials that allowed us to gather many interesting human and technological results. To fulfil the technological and experimental goals of the project, we have modified an existing CVE platform: the DIVE (distributed interactive virtual environment) toolkit. In this paper, we present the different services and extensions that have been implemented within the platform during the four years of the project. Such a presentation will exemplify the different features that will have to be offered by next-generation CVE platforms. Implementation of the COVEN services has had implications at all levels of the platform: from a new networking layer through to mechanisms for high-level semantic modelling of applications.
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| 7. |
- Frecon, Emmanuel, et al.
(författare)
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Visualising sound perception in a submarine: a museum installation
- 2004. - 2
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Konferensbidrag (refereegranskat)abstract
- We describe a museum installation that explains the technical and mental process that sonar operators undergo when identifying underwater sounds in the surroundings of a submarine. The installation places the public in a cramped space composed of several coupled interactive stations offering different perspectives onto a virtual environment representing a part of the Baltic Sea. The virtual environment and its presentation within the installation are implemented as an application of the DIVE research toolkit. The installation has been on display in several museums on a daily basis for over a year. We describe the technical solutions that we have employed to realise the installation and some of our learning.
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| 8. |
- Geuens, Sam, et al.
(författare)
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Testing a Home Solution for Preparing Young Children for an Awake MRI : A Promising Smartphone Application
- 2023
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Ingår i: Children. - : Multidisciplinary Digital Publishing Institute (MDPI). - 2227-9067. ; 10:12
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Tidskriftsartikel (refereegranskat)abstract
- Thanks to its non-invasive nature and high-resolution imaging capabilities, magnetic resonance imaging (MRI) is a valuable diagnostic tool for pediatric patients. However, the fear and anxiety experienced by young children during MRI scans often result in suboptimal image quality and the need for sedation/anesthesia. This study aimed to evaluate the effect of a smartphone application called COSMO@home to prepare children for MRI scans to reduce the need for sedation or general anesthesia. The COSMO@home app was developed incorporating mini-games and an engaging storyline to prepare children for learning goals related to the MRI procedure. A multicenter study was conducted involving four hospitals in Belgium. Eligible children aged 4–10 years were prepared with the COSMO@home app at home. Baseline, pre-scan, and post-scan questionnaires measured anxiety evolution in two age groups (4–6 years and 7–10 years). Eighty-two children participated in the study, with 95% obtaining high-quality MRI images. The app was well-received by children and parents, with minimal technical difficulties reported. In the 4–6-year-old group (N = 33), there was a significant difference between baseline and pre-scan parent-reported anxiety scores, indicating an increase in anxiety levels prior to the scan. In the 7–10-year-old group (N = 49), no significant differences were observed between baseline and pre-scan parent-reported anxiety scores. Overall, the COSMO@home app proved to be useful in preparing children for MRI scans, with high satisfaction rates and successful image outcomes across different hospitals. The app, combined with minimal face-to-face guidance on the day of the scan, showed the potential to replace or assist traditional face-to-face training methods. This innovative approach has the potential to reduce the need for sedation or general anesthesia during pediatric MRI scans and its associated risks and improve patient experience.
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| 9. |
- Karlgren, Jussi, et al.
(författare)
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Socially intelligent interfaces for increased energy awareness in the home
- 2008. - 2
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Ingår i: The Internet of Things. - Berlin, Heidelberg : Springer. ; , s. 263-275
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Bokkapitel (refereegranskat)abstract
- This paper describes how home appliances might be enhanced to improve user awareness of energy usage. Households wish to lead comfortable and manageable lives. Balancing this reasonable desire with the environmental and political goal of reducing electricity usage is a challenge that we claim is best met through the design of interfaces that allows users better control of their usage and unobtrusively informs them of the actions of their peers. A set of design principles along these lines is formulated in this paper. We have built a fully functional prototype home appliance with a socially aware interface to signal the aggregate usage of the user's peer group according to these principles, and present the prototype in the paper.
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| 10. |
- Lind, Ann-Kristina, et al.
(författare)
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Smart övervakning av nötkreatur på bete
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Smart monitoring of cattle on pasture According to the Swedish Board of Agriculture, meadows and pastures have decreased by hundreds of thousands of hectares in Sweden over the past hundred years. Valuable pastures can be located far from the farm, which means that the farmer chooses not to use it as it means long transport distances for daily supervision and monitoring of the animals. The problem has become more common with the structural change towards fewer and larger farms that has taken place in agriculture in recent decades. Farmers can, when the pasture is far from the farm, hire people who live closer to the pasture for the day-to-day care of the animals. However, counting the animals can be a task that is difficult to maintain, as it can be difficult even for an experienced zookeeper, especially if it is a larger group of animals and hilly terrain. If this step is handled automatically, it will be easier for the farmer to hire another person for the daily care of the animals and thus the possibility of using hard-to-reach pasture is increased. The project focused on finding low-cost and smart technical solutions to facilitate the tracking of animals, with the aim of developing a monitoring system for cattle on pasture to ensure that the animals are counted as part of a farmer’s daily supervision. The monitoring system that has been developed uses satellite communication to send the position of the animals up to four times a day to a mobile app, which gives the farmers an indication that all the animals have moved. In addition, the farmer receives alarms via email if the animals have too little activity or have moved outside of their designated pasture. Based on the experience from the field trials that were carried out, and from feedback from the farmers who participated in the project, it is concluded that the monitoring system can facilitate the monitoring of animals on pasture and at the same time be economically viable for a farmer. However, there is an opportunity to further develop the monitoring system to add functions such as water and electrical fence monitoring, which would make it possible to handle even more of the daily supervision digitally and only have manual supervision a few times a week.
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